Methods and compositions for soluble CPG15
OwnerElly Nedivi, Ulrich Putzinventors
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Abstract
Disclosed herein are compositions of soluble CPG15 and methods for treating conditions of excessive cell death, such as neurological conditions, using such compositions. Compounds that inhibit the activity of soluble CPG15 are also disclosed herein for the treatment of conditions of undesirable cell survival, such as cancer.
Claims58
A method of treating or preventing a condition of excessive cell death in a subject, said method comprising administering to said subject a soluble CPG15 (s-CPG15) compound having s-CPG15 biological activity in an amount and for a time sufficient to prevent, reduce, or eliminate the symptoms of said condition.
A method of reducing or preventing cell death, said method comprising administering to a cell s-CPG15 in an amount and for a time sufficient to reduce or prevent said cell death.
A method of promoting the survival or differentiation of a cell comprising administering to said cell s-CPG15 for a time and in an amount to promote the survival or differentiation of said cell.
A composition of matter comprising a purified polypeptide having s-CPG15 biological activity.
A method of treating or preventing a condition of undesirable cell survival in a subject, said method comprising administering to said subject a purified antibody or antigen-binding fragment that specifically binds a polypeptide having s-CPG15 biological activity, wherein said administering is in an amount and for a time sufficient to prevent, reduce, or eliminate the symptoms of said condition.
A method of treating or preventing a condition of undesirable cell survival in a subject, said method comprising administering to said subject a double-stranded RNA that is complementary to an mRNA sequence encoding a protein having s-CPG15 biological activity, wherein said administering is sufficient to reduce or inhibit the expression of s-CPG15.
A method of treating or preventing a condition of undesirable cell survival in a subject, said method comprising administering to said subject a nucleic acid encoding a truncated form of CPG15, wherein said administering is sufficient to reduce or inhibit the biological activity of s-CPG15.
A method of treating or preventing a condition of undesirable cell survival in a subject, said method comprising administering to said subject a compound comprising a truncated form of CPG15 protein, wherein said administering is sufficient to reduce or inhibit the biological activity of s-CPG15.
A method of enhancing cell death, said method comprising administering to a cell an antibody or antigen-binding fragment that specifically binds s-CPG15.
A method of enhancing cell death, said method comprising administering to a cell a double-stranded RNA that is complementary to an mRNA sequence encoding a protein having s-CPG15 biological activity.
A method of enhancing cell death, said method comprising administering to a cell a nucleic acid encoding a truncated form of CPG15, wherein said administering is sufficient to reduce or inhibit the biological activity of s-CPG15.
A method of enhancing cell death, said method comprising administering to a cell a compound comprising a truncated form of CPG15 protein, wherein said administering is sufficient to reduce or inhibit the biological activity of s-CPG15.
A composition of matter comprising a purified antibody or antigen-binding fragment thereof that specifically binds s-CPG15.
A composition of matter comprising an siRNA that is complementary to an MRNA sequence encoding s-CPG15.
A method of manufacturing s-CPG15 comprising expressing said s-CPG15 protein in a population of cells and isolating from the supernatant of said cell population said s-CPG15.
A method of identifying a candidate compound that modulates cell death, cell survival, or cellular differentiation pathways, said method comprising the steps of
- (a.) mixing s-CPG15 with a test mixture,
- (b.) identifying a candidate compound in said mixture that interacts with said s-CPG15.
Dependencies are inferred from the claim text.