Tip39 polypeptides
OwnerHarald Juppner, Thomas J Gardella +3inventors
InventorsHarald Juppner, Thomas J Gardella, Kenneth P Jonsson, Markus R John, Robert C Gensure
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Abstract
The invention relates to truncated TIP39 polypeptides and chimeric PTHrP/TIP polypeptides. The polypeptides are used as agonists or antagonists of PTH receptors in various medical conditions.
Claims23
1 An isolated polypeptide consisting of the amino acid sequence AFRERARLLAALERRHWLNSYMHKLLVLDAP. [SEQ ID No.:1] or ALADDAAFRERARLLAALERRHWL NSYMHKLLVLDAP. [SEQ ID No.:2]
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of AFRERARLLAALERRHWLNSYMHKLLVLDAP. [SEQ ID No.:1] ALADDAAFRERARLLAALERRHWLNSYMHKL LVLDAP. [SEQ ID No.:2], AAFRERARLLAALERR HWLNSYMHKLLVLDAP [SEQ ID No.:3], FRERARLLAALERRHWLNSYMHKLLVLDAP [SEQ ID No.:4], AFRERARLLAALERRHWLNSYMHKLLVLDAP. [SEQ ID No.:1]. RERARLLAALERRHWLNSYMHKLLVLDAP [SEQ ID No.:5] and ERARLLAALERRHW LNSYMHKLLVLDAP [SEQ ID No.:6], wherein said polypeptide sequence is not TIP7-39.
An isolated polypeptide, wherein said polypeptide is a truncated polypeptide of TIP39 (SLALADDAFRERARLLAALERRH LNSYMHKLLVLDAP) [SEQ ID No.:7] and said truncated polypeptide is not TIP7-39.
An isolated polypeptide comprising the sequence AFRERARLLA, wherein said sequence is not that of the polypeptide TIP39 or TIP7-39 and said isolated polypeptide binds to PTH1R or PTH2R.
A PTH1R or PTH2R antagonist comprising a truncated TIP39 polypeptide wherein said antagonist is not TIP7-39.
A PTH1R agonist comprising a sequence of the chimeric polypeptide selected from the group of sequences consisting of PTHrP(1-20)/TIP(23-39) (AVSEHQLLHDKGKSI QDLRR RHWLNSYMHKLLVLDAP) [SEQ ID NO:12], PTHrP(1-9)/TIP(12-39) (AVSEHQLLH ERARLLAALER RHWLNSYMHKLLVLDAP) [SEQ ID NO:13] and PTHrP(1-13)/TIP(16-39)(AVSEHQLLHDKGK LLAALER RHWLNSYMHKLLVLDAP) [SEQ ID NO:14].
A method for treating mammalian conditions characterized by an abnormality related to the activated PTH2R.
Dependencies are inferred from the claim text.