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US 2004/0176281 A1Published application
Delivery systems
AssigneeAlchemia Pty Ltd
InventorsIstvan Toth, Robert Falconer, Shaun Emmanuel De Cruz, Ross Peter McGeary, Benjamin Paul Ross
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Abstract
The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.
Claims23
A compound of general formula I:
- r[D(nz)]p [(Wq—S—X-L)(my)] formula I
- in which D is a therapeutically useful molecule;
- r is an integer greater than or equal to 1;
- p, n and m may be the same or different, and are independently integers greater than or equal to 1;
- n and m represent the overall magnitude of the charge on the molecules;
- and
- z and y are charges, either positive (+) or negative (−), such that when z is positive, y is negative and vice versa;
- and [(Wq—S—X-L)(my)] is a carrier compound, in which
- X is a covalent bond, or is a linker group, selected from 2 to 14 atom spacers, which may be substituted or unsubstituted, branched or linear;
- S is a mono- or oligosaccharide;
- L is a lipidic moiety;
- W may be absent, or is a 3 to 10 atom alkyl or heteroalkyl spacer, which may be branched or linear, and is substituted with one or more functional groups, each of which is charged or is capable of carrying a charge under physiological conditions;
- and
- q is 0 when w is absent, or is an integer, which ranges from 3 to the number of hydroxyls available for substitution on the mono- or oligosaccharide.
11 more elements
Dependencies are inferred from the claim text.