Pharmaceutical composition for alleviating tissue hypoxia and methods for alleviating tissue hypoxia
AssigneesTokyo Metropolitan Foundation for Research on Aging and Promotion of Welfare, Lss Co. Ltd.
InventorsTakuji Shirasawa, Takahiko Shimizu
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Abstract
A pharmaceutical composition for alleviating tissue hypoxia, comprising (1) α-globin having the Titusville mutation, (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of the α-globin having the Titusville mutation, or (3) an expression vector comprising the polynucleotide, and a pharmaceutically acceptable carrier or diluent, is disclosed. Further, a method for alleviating tissue hypoxia comprising administering the same to a subject, and a transgenic non-human animal having expressably a polynucleotide comprising a base sequence encoding an amino acid sequence of α-globin having the Titusville mutation, are disclosed.
Claims13
A pharmaceutical composition for alleviating tissue hypoxia, comprising
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, and a pharmaceutically acceptable carrier or diluent.
A method for alleviating tissue hypoxia, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
A method for treating or preventing ischemic conditions, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
A method for enhancing an oxygen metabolism in tissues, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
A method for modificating of a tissue, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
A method for enhancing exercise capacity, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
A method for treating or preventing cerebrovascular dementia, comprising administering to a subject in need thereof
- (1) α-globin having the Titusville mutation,
- (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of said α-globin having the Titusville mutation, or
- (3) an expression vector comprising said polynucleotide, in an amount effective therefor.
An artificial blood comprising α-globin having the Titusville mutation.
A transgenic non-human animal having expressably a polynucleotide comprising a base sequence encoding an amino acid sequence of α-globin having the Titusville mutation.
Dependencies are inferred from the claim text.