4-(Benzylidene-amino)-3-methylsulfanyl)-4h-(1,2,4)triazin-5-one derivatives having a pde-iv inhibiting and tnf-antagonistic effect for the treatment of cardiac diseases and allergies

Compounds of the formula I

• 106
• in which
• R1 and R2 are each, independently of one another, H, OH, OR6, SR6, SOR6, SO2R6, Hal or together are alternatively —O—CH2—O—,
• A is R3- and R4-substituted phenyl, 2-, 3- or 4-pyridyl, 4- or 5-pyrimidyl, 3- or 4-pyridazyl or 2- or 3-pyrazinyl,
• R3 and R4 are each, independently of one another, H, OH, OR6, SR6, SOR6, SO2R6, R6, Hal or together are alternatively —O—CH2—O—,
• R5 is H or alkyl having from 1 to 10 carbon atoms,
• R6 is alkyl having from 1 to 10 carbon atoms, which may be substituted by from 1 to 5 F and/or Cl atoms, cycloalkyl having 3-7 carbon atoms, alkylenecycloalkyl having 5-10 carbon atoms or alkenyl having 2-8 carbon atoms,
• Hal is F, Cl, Br or I, and physiologically acceptable salts and solvates thereof.