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US 2004/0175841 A1Published application
Detection and amplification of ligands
AssigneeKent State University
InventorsGary D. Niehaus, Christopher J. Woolverton, Oleg D. Lavrentovich
Life of this patent
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Abstract
Devices and systems for the detection of ligands comprising at least one receptor and an amplification mechanism comprising a liquid crystalline, where an amplified signal is produced as a result of receptor binding to a ligand are provided. Also provided are methods for the automatic detection of ligands.
Claims19
A device for the detection of ligands comprising:
- at least one substrate;
- at least one receptor attached to said substrate, wherein said at least one receptor is capable of binding to a ligand to form a receptor-ligand complex and wherein the formation of said receptor-ligand complex produces a signal;
- and
- an amplification mechanism interfaced with said receptor comprising a liquid crystalline material, wherein said amplification mechanism amplifies said signal upon receptor-ligand complex formation.
1 more element
A method for detecting ligands comprising:
- providing a device for detecting ligands, said device comprising at least one substantially spherical substrate;
- at least one receptor attached to said spherical substrate, wherein said at least one receptor is capable of binding to a ligand to form a receptor-ligand complex and wherein the formation of said receptor-ligand complex produces a signal;
- and an amplification mechanism interfaced with said receptor comprising a liquid crystalline material, wherein said amplification mechanism amplifies said signal upon receptor-ligand complex formation;
- exposing a sample containing at least one ligand to said at least one substrate;
- allowing said receptor to interact with said at least one ligand to form at least one receptor-ligand complex, thereby producing a signal;
- amplifying the signal with the amplification mechanism;
- and measuring the amplified signal produced by said receptor-ligand complex formation.
4 more elements
A device for the detection of ligands comprising:
- at least one substantially spherical substrate coated with a receptor- binding material;
- at least one receptor attached to said coated spherical substrate, wherein said at least one receptor is capable of binding to a ligand to form a receptor-ligand complex and wherein the formation of said receptor-ligand complex produces a signal;
- and
- an amplification mechanism interfaced with said receptor comprising a liquid crystalline material, wherein said amplification mechanism amplifies said signal upon receptor-ligand complex formation.
1 more element
Dependencies are inferred from the claim text.