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OwnerKristin H. Jarman, William R. Cannon +2inventors
InventorsKristin H. Jarman, William R. Cannon, Kenneth D. Jarman, Alejandro Heredia-Langner
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Peptides are identified from a list of candidates using collision-induced dissociation tandem mass spectrometry data. A probabilistic model for the occurrence of spectral peaks corresponding to frequently observed partial peptide fragment ions is applied. As part of the identification procedure, a probability score is produced that indicates the likelihood of any given candidate being the correct match. The statistical significance of the score is known without necessarily having reference to the actual identity of the peptide. In one form of the invention, a genetic algorithm is applied to candidate peptides using an objective function that takes into account the number of shifted peaks appearing in the candidate spectrum relative to the test spectrum.
A method of quantifying the relationship between a test spectrum and a reference spectrum from a mass spectrometry device, where the reference spectrum is related to a known peptide sequence, comprising:
An apparatus comprising a processor and a memory in communication with said processor, wherein said memory contains programming instructions executable by said processor to:
A method of scoring the relationship between a plurality of candidate peptides and a sample, comprising:
A method of finding one or more possible matching peptides to a test peptide associated with a tandem mass spectrometry test spectrum s, comprising:
Dependencies are inferred from the claim text.