Human RNase III and compositions and uses thereof
OwnerStanley T. Crooke, HongJiang Wuinventors
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Abstract
The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
Claims75
A method of modulating RNA interference in a cell or tissue comprising contacting said cell or tissue with an amount of a modulator effective to modulate RNA interference by at least 50% as compared to a control wherein the modulator is a human RNase III polypeptide or an oligomeric compound targeted to a nucleic acid encoding human RNase III.
A method of modulating processing of an RNA in a cell or tissue comprising contacting said cell or tissue with an amount of a modulator effective to modulate RNA processing by at least 50% as compared to a control, wherein the modulator is a human RNase III polypeptide or an oligomeric compound targeted to a nucleic acid encoding human RNase III.
A method of modulating RNA expression in a cell or tissue comprising contacting said cell or tissue with an amount of a modulator effective to modulate RNA expression by at least 50% as compared to a control, wherein the modulator is a human RNase III polypeptide or an oligomeric compound targeted to a nucleic acid encoding human RNase III.
A method of modulating RNA splicing in a cell or tissue comprising contacting said cell or tissue with an amount of a modulator effective to modulate RNA splicing by at least 50% as compared to a control, wherein the modulator is a human RNase III polypeptide or an oligomeric compound targeted to a nucleic acid encoding human RNase III.
A method of modulating RNA translocation in a cell or tissue comprising contacting said cell or tissue with an amount of a modulator effective to modulate RNA translocation as compared to a control.
Dependencies are inferred from the claim text.