Monoclonal antibody binding to mt4-mmp catalytic domain

Abstract

The present invention relates to a monoclonal antibody which specifically reacts with natural MT4-MMP or solubilized MT4-MMP. Also, the present invention provides a monoclonal antibody which specifically and efficiently recognizes a natural MT4-MMP catalytic domain; a human chimeric antibody, a CDR-grafted antibody, a single chain antibody and a disulfide stabilized antibody, comprising the same; and a method for detecting and determining MT4-MMP protein using the antibodies. Furthermore, the present invention provides a diagnostic method, a diagnostic agent and a therapeutic agent for various diseases relating to MP4-MMP such as inflammation and cancer, using the antibodies.

Dependencies are inferred from the claim text.