Mutant P53 proteins and uses thereof
OwnerKimberly Kline, Bob G. Sanders +1inventors
InventorsKimberly Kline, Bob G. Sanders, Weiping Yu
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Abstract
Mutated p53 proteins comprising amino acids deletion were disclosed herein. The mutant p53 exhibits high cellular retention and is capable of rendering tumor cells sensitive to apoptotic inducing agents such as γ-irradiation or chemotherapeutic agents. The mutant p53 protein can be delivered separately or in combination with apoptotic inducing agents via aerosol liposome/transfection/infection methods to treat cellular proliferative diseases and disorders in humans and animals.
Claims26
An isolated p53 mutated protein having the amino acid sequence of SEQ ID NO. 8.
An isolated and purified DNA encoding a p53 mutated protein having an amino acid sequence of SEQ ID NO:
- 8.
A vector comprising (a) an isolated DNA encoding a mutated p53 protein selected from the group consisting of SEQ ID NOs. 2 and 8;
- and (b) regulatory elements necessary for expressing said DNA in a cell.
Dependencies are inferred from the claim text.