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OwnerJason M. Johnson, Philip W. Garrett-Engele +1inventors
InventorsJason M. Johnson, Philip W. Garrett-Engele, Zhengyan Kan
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The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma (IKBKG). The polynucleotide sequences of IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 are provided by SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The amino acid sequences for IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 are provided by SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9, and SEQ ID NO 11, respectively. The present invention also provides methods for using IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 polynucleotides and proteins to screen for compounds that bind to IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3, respectively.
A purified human nucleic acid comprising SEQ ID NO 4, or the complement thereof.
A purified polypeptide comprising SEQ ID NO 5.
An expression vector comprising a nucleotide sequence encoding SEQ ID NO 5, wherein said nucleotide sequence is transcriptionally coupled to an exogenous promoter.
A method for screening for a compound able to bind to IKBKGsv1 comprising the steps of:
A method of screening for compounds able to bind selectively to IKBKGsv1 comprising the steps of:
A method for screening for a compound able to bind to or interact with a IKBKGsv1 protein or a fragment thereof comprising the steps of:
Dependencies are inferred from the claim text.