G protein coupled receptors and dna sequences thereof
OwnerUmesh Bhatia, Carol Elizabeth Jones +3inventors
InventorsUmesh Bhatia, Carol Elizabeth Jones, Rochdi Bouhelal, Klaus Seuwen, Laurent Tenaillon
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Abstract
This invention relates to newly identified polypeptides and polynucleotides encoding respiratory chemokine receptor polypeptides and polynucleotides, to their use in diagnosis and in identifying compounds that may be agonists and antagonists that are potentially useful in therapy, and to production of such polypeptides and polynudeotides, belonging to the class of G protein-coupled receptors.
Claims10
An isolated polypeptide selected from one of the groups consisting of:
- (a) an isolated polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO 1 or SEQ ID No.5;
- (b) an isolated polypeptide comprising a polypeptide sequence having at least 95% identity to the polypeptide sequence of SEQ ID NO 2 or SEQ ID NO.6;
- (c) an isolated polypeptide having at least 95% identity to the polypeptide sequence of SEQ ID NO 2 or SEQ ID NO.6;
- and
- (d) the polypeptide sequence of SEQ ID NO 2 or SEQ ID NO.6 and
- (e) fragments and variants of such polypeptides in (a) to (d).
An isolated polynucleotide selected from one of the groups consisting of:
- (a) an isolated polynucleotide comprising a polynucleotide sequence having at least 95% identity to the polynucleotide sequence of SEQ ID NO 1 or SEQ ID NO.5;
- (b) an isolated polynucleatide having at least 95% identity to the polynucleotide of SEQ ID NO 1 or SEQ ID NO 5;
- (c) an isolated polynucleotide comprising a polynucleotide sequence encoding a polypeptide sequence having at least 95% identity to the polypeptide sequence of SEQ ID NO 2 or SEQ ID No.6;
- (d) an isolated polynucleotide having a polynucleotide sequence encoding a polypeptide sequence having at least 95% identity to the polypeptide sequence of SEQ ID NO 2 or SEQ ID NO.6;
- (e) an isolated polynucleotide with a nucleotide sequence of at least 100 nucleotides obtained by screening a library under stringent hybridization conditions with a labeled probe having the sequence of SEQ ID NO 1 or SEQ ID NO 5 or a fragment thereof having at least 15 nucleotides;
- (f) a polynucleotide which is the RNA equivalent of a polynucleotide of (a) to (e);
- or a polynucleotide sequence complementary to said isolated polynucleotide and polynucleotides that are variants and fragments of the above mentioned polynucleotides or that are complementary to above mentioned polynucleotides, over the entire length thereof.
Dependencies are inferred from the claim text.