Anti-cd3 single-chain antibodies having human cmu3 and cmu4 domains

Abstract

The invention relates to a single-chain antibody which is characterized in that (a) it contains a variable domain (scFv) binding specifically to human CD3, and (b) its constant domains are derived from a human IgM molecule and comprise the Cμ3 domain and the Cμ4 domain but not the Cμ1 domain and the Cμ2 domain. In a preferred embodiment, the antibody according to the invention contains a human IgG3 hinge region between the variable and constant domains. The invention also relates to DNA sequences coding for this antibody and to expression vectors containing these DNA sequences and finally to preparations containing the above compounds, preferably for the prevention of acute rejection reactions following organ transplantation.

Dependencies are inferred from the claim text.