Method for calibrating antibiotic disk diffusion testing of microorganisms
AssigneeBioscand AB
InventorGoran Kronvall
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Abstract
A method for calibrating antimicrobic susceptibility testings of microorganisms comprises the steps of creating a histogram with a high response side and a low response side of isolates from a microbial species, which may contain resistant strains against an antimicrobial agent, calculating from the high response side of the histogram at least one statistical parameter, and defining a limit for susceptibility interpretation and comparative analysis of antimicrobic resistance, which is based on the statistical parameter. This limit separates susceptible strains from resistant strains against an antimicrobial agent.
Claims22
A method for calibrating antimicrobic susceptibility testings of microorganisms, characterized in that the method comprises the steps of
- creating a histogram of isolates from a microbial species, which may contain unknown resistant strains against an antimicrobial agent, by plotting in vitro susceptibility test data for said microbial species against said antimicrobial agent on the y axis and registered response values against said antimicrobial agent on the x axis, said histogram being divided into a high response side and a low response side;
- calculating from said high response side of said histogram at least one statistical parameter;
- and
- defining a limit for susceptibility interpretation and comparative analysis of antimicrobic resistance, which is based on said at least one statistical parameter;
- said limit separating susceptible strains from resistant strains against said antimicrobial agent.
Dependencies are inferred from the claim text.