Method of screening for chemotherapeutic treatments for cancer
OwnerNori Matsunami, Raymond White +1inventors
InventorsNori Matsunami, Raymond White, Jun Liu
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Abstract
The present invention provides a method of screening for potential cancer chemotherapeutic and chemopreventive agents which act by inducing or mimicking the activity of Siah-1 in humans. This invention also provides methods of administering such agents to treat cancer by inducing or mimicking the activity of Siah-1, thus causing the degradation of β-catenin.
Claims35
A method of screening for potential cancer chemotherapeutic agents comprising:
- a. contacting a cell with a test compound;
- and
- b. measuring induction of Siah-1, wherein a test compound which induces Siah-1 is a potential cancer chemotherapeutic agent.
A method of screening for potential cancer chemotherapeutic agents comprising:
- a. contacting a cell with a test compound, wherein the cell expresses or over-expresses β-catenin and Siah-1 is suppressed in the cell;
- and
- b. measuring degradation of β-catenin, wherein a test compound that induces the degradation of β-catenin is a potential cancer chemotherapeutic agent.
A method of screening for potential cancer chemotherapeutic agents comprising:
- a. administering a test compound to an animal;
- and
- b. measuring induction of Siah-1, wherein a test compound which induces Siah-1 is a potential cancer chemotherapeutic agent.
A method of screening for potential cancer chemotherapeutic agents comprising the steps of:
- a administering a test compound to an animal;
- and
- b. measuring degradation of β-catenin, wherein a test compound that induces the degradation of β-catenin is a potential cancer chemotherapeutic agent.
A method for degrading β-catenin in a human, comprising administering a compound which mimics the activity of Siah-1 to a human in need of such treatment.
A method for degrading β-catenin in a human, comprising administering a compound which activates Siah-1 to a human in need of such treatment.
A method for degrading β-catenin in a human, comprising administering a compound that mediates the degradation of β-catenin, wherein the ability of the compound mediate the degradation of β-catenin is determined by:
- a. contacting a cell with a test compound;
- and
- b. measuring induction of Siah-1, wherein a test compound which induces Siah-1 is a potential cancer chemotherapeutic agent.
A method for treating cancer in a human suffering therefrom, comprising administering a compound that induces Siah-1 activity to a human in need of such treatment.
A method for treating cancer in a human suffering therefrom, comprising administering a compound that mimics Siah-1 activity to a human in need of such treatment.
Dependencies are inferred from the claim text.