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OwnerHiroshi Saito, Kiyonori Katsuragai +4inventors
InventorsHiroshi Saito, Kiyonori Katsuragai, Tetsuya Tachikawa, Michinori Tanaka, Koichi Ogino, Takao Taki
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The invention provides that examination reagents useful in diagnosing Crohn's disease and a method of conveniently and accurately detecting the occurrence of Crohn's disease. The examination reagents contain as the active ingredient a Crohn's disease antibody-binding protein as defined in the following (a) or (b): (a) a peptide consisting of an amino acid sequence selected from among the amino acid sequences represented by SEQ ID NOS:1 to 4; and (b) a peptide consisting of an amino acid sequence derived from the above-mentioned amino acid sequence (a) by substitution, deletion or addition of one to several amino acids and being capable of binding to the Crohn's disease antibody. The examination method can be carried out by detecting the presence/absence of an antibody recognizing human vacuolar H+-transport ATPase, a human nuclear protein (Homo sapiens kruppel-like zinc finger protein 300) or rice allergen in a biological sample of a subject.
A Crohn's disease antibody-binding peptide (a) or (b):
A branched multiple antigenic peptide containing the amino acid sequence of the following:
An examination method for Crohn's disease which comprises a step of detecting the presence of an antibody recognizing human vacuolar H+-transport ATPase in a biological sample from a subject.
An examination method for Crohn's disease which comprises a step of detecting the presence of an antibody recognizing a human nuclear protein (Homo sapiens kruppel-like zinc finger protein 300) in a biological sample from a subject.
An examination method for Crohn's disease which comprises a step of detecting the presence of an antibody recognizing a rice allergen protein in a biological sample from a subject.
Dependencies are inferred from the claim text.