HSV-2 type-specific immunoassays using glycoprotein G2 peptides
AssigneeBio-Rad Laboratories, Inc.
InventorsPeilin Chen, Peter Su, Hao Yu, Lawrence J. Blecka, Patrick F. Coleman
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Abstract
The present invention relates to peptides that are derived from HSV-2 glycoprotein G2 and represent HSV-2 type-specific epitopes. The present invention also provides for compositions comprising these peptides for type-specific serological diagnosis of HSV-2 infection. Methods of using these peptides for type-specific detection of HSV-2 antibodies and differentiation of HSV-2 viral infection from HSV-1 and other herpes family viral infections are further provided.
Claims59
A composition comprising an HSV-2 peptide consisting of 24 to 36 contiguous amino acids of SEQ ID NO:1.
A method for specific detection of HSV-2 antibodies in a biological sample, comprising the steps of:
- (a) contacting the biological sample with a composition comprising a peptide consisting of 24 to 36 contiguous amino acids of SEQ ID NO:1, wherein the peptide is linked to a carrier;
- and
- (b) detecting whether antigen-antibody binding has occurred between the peptide and an antibody component of the biological sample, in which the detection of antigen-antibody binding indicates the presence of HSV-2 antibodies in the biological sample.
Dependencies are inferred from the claim text.