Polynucleotide sequences and corresponding encoded polypeptides of particular secreted and membrane-bound proteins overexpressed in certain cancers
OwnerQianjin Hu, Alan Peng +5inventors
InventorsQianjin Hu, Alan Peng, Bin Liu, James Robert Love, Xiaofeng Hao, Min Ren, Zhumei Sheng
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Abstract
The present invention relates to the identification of the over expression of certain genes encoding certain secreted and membrane-bound proteins in breast, lung, colon and kidney cancers. Knowledge that these genes are over expressed in the cancers is useful for the detection, diagnosis, prevention and treatment of the specific cancers.
Claims52
A method of breast cancer diagnosis comprising detecting over expression of a gene of a protein found in breast tissue selected from the group consisting of ATP transporter protein, GPCR (G-protein coupled receptor), GPCR (G-protein coupled receptor) 14, hypothetical protein (breast), unc-93, bone marrow stromal cell antigen 2, cadherin EGF LAG seven-pass G-type receptor 1 flamingo (Drosophila) homolog, carcinoembryonic antigen-related cell adhesion molecule 3, carcinoembryonic antigen-related cell adhesion molecule 6, carcinoembryonic antigen-related cell adhesion molecule 8, claudin 7, cleft lip and palate associated membrane transmembrane protein 1, fibroblast growth factor receptor 3, heme oxygenase (decycling) 1, immediate early response 3, mucin 1 transmembrane, NG22, phosphatidylinositol glycan (class Q), similar to CGI-78 protein, clone MGC:4880 IMAGE:3457593, solute carrier family 1 (member 4), solute carrier family 6 (member 8), tetraspan 1, transporter 1 ATP-binding cassette sub-family B (MDR/TAP) and Type I transmembrane receptor (seizure-related protein).
A method of breast cancer treatment comprising blocking over expression of a gene encoding a secreted or membrane-bound protein found in breast tissue selected from the group consisting of SEQ ID Nos 1-154 in the file “14dec03.ST25.txt” (generated by PatentIn3.2) attached to this application and incorporated by reference.
A method of lung cancer diagnosis comprising detecting over expression of a gene of a protein found in lung tissue selected from the group consisting of over expressed in lung of hypothetical protein, amino acid transporter 2, carboxypeptidase M, and putative G-protein coupled receptor.
A method of lung cancer treatment comprising blocking over expression of a gene encoding a secreted or membrane-bound protein found in lung tissue selected from the group consisting of SEQ ID Nos 155-184 in the file “14dec03.ST25.txt” (generated by PatentIn3.2) attached to this application and incorporated by reference.
A method of colon cancer diagnosis comprising detecting over expression of a gene of a protein found in colon tissue selected from the group consisting of hypothetical protein (colon), cadherin, formyl peptide receptor 1, AE-binding protein 1, solute carrier family 21 (organic anion transporter) member 12, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I), Type I transmembrane protein Fn14, hypoxia-inducible protein 2, alpha-2-glycoprotein 1 zinc, chitinase 3-like1 (cartilage glycoprotein-39) and triggering receptor expressed on myeloid cells 2.
A method of colon cancer treatment comprising blocking over expression of a gene encoding a secreted or membrane-bound protein found in colon tissue selected from the group consisting of SEQ ID Nos 185-246 in the file “14dec03.ST25.txt” (generated by PatentIn3.2) attached to this application and incorporated by reference.
A method of kidney cancer diagnosis comprising detecting over expression of a gene of a protein found in kidney tissue selected from the group consisting of scavenger receptor class B, adenosine receptor A3, CD97 antigen, APO E-C2 gene, basement membrane-induced gene, integrin alpha 5 (fibronectin receptor, alpha polypeptide), peptide transporter 3, hypothetical protein FLJ22341, solute carrier family 16 (monocarboxylic acid transporters), interleukin 10 receptor alpha, FXYD domain-containing ion transport regulator 5, retinoic acid receptor responder (tazarotene induced) 2, integrin alpha X (antigen CD11C (p150), alpha polypeptide), sema domain seven thrombospondin repeats (type 1 and type 1-like) transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 5B, guanylate binding protein 1 interferon-inducible 67 kD, leukocyte immunoglobulin-like receptor subfamily B, discoidin domain receptor family member 2, caveolin 1 caveolae protein 22 kD, chloride intracellular channel 1, CD36 antigen (collagen type I receptor, thrombospondin recep), small inducible cytokine A4 (homologous to mouse Mip-1b), lysosomal-associated multispanning membrane protein-5, integrin beta 2 antigen CD18 (p95) lymphocyte funtion-assoc, chemokine (C-X-C motif) receptor 4 (fusin), CD2 antigen (p50) sheep red blood cell receptor and epithelial membrane protein 3.
A method of kidney cancer treatment comprising blocking over expression of a gene encoding a secreted or membrane-bound protein found in kidney tissue selected from the group consisting of SEQ ID Nos 247-385 in the file “14dec03.ST25.txt” (generated by PatentIn3.2) attached to this application and incorporated by reference.
An antibody or binding portion of an antibody that specifically binds a protein found in breast tissue, wherein the protein is selected from the group consisting of ATP transporter protein, GPCR (G-protein coupled receptor), GPCR (G-protein coupled receptor) 14, hypothetical protein (breast), unc-93, bone marrow stromal cell antigen 2, cadherin EGF LAG seven-pass G-type receptor 1 flamingo (Drosophila) homolog, carcinoembryonic antigen-related cell adhesion molecule 3, carcinoembryonic antigen-related cell adhesion molecule 6, carcinoembryonic antigen-related cell adhesion molecule 8, claudin 7, cleft lip and palate associated membrane transmembrane protein 1, fibroblast growth factor receptor 3, heme oxygenase (decycling) 1, immediate early response 3, mucin 1 transmembrane, NG22, phosphatidylinositol glycan (class Q), similar to CGI-78 protein, clone MGC:4880 IMAGE:3457593, solute carrier family 1 (member 4), solute carrier family 6 (member 8), tetraspan 1, transporter 1 ATP-binding cassette sub-family B (MDR/TAP) and Type I transmembrane receptor (seizure-related protein).
A method of breast cancer treatment comprising blocking an over expressed protein selected from the group consisting of ATP transporter protein, GPCR (G-protein coupled receptor), GPCR (G-protein coupled receptor) 14, hypothetical protein (breast), unc-93, bone marrow stromal cell antigen 2, cadherin EGF LAG seven-pass G-type receptor 1 flamingo (Drosophila) homolog, carcinoembryonic antigen-related cell adhesion molecule 3, carcinoembryonic antigen-related cell adhesion molecule 6, carcinoembryonic antigen-related cell adhesion molecule 8, claudin 7, cleft lip and palate associated membrane transmembrane protein 1, fibroblast growth factor receptor 3, heme oxygenase (decycling) 1, immediate early response 3, mucin 1 transmembrane, NG22, phosphatidylinositol glycan (class Q), similar to CGI-78 protein, clone MGC:4880 IMAGE:3457593, solute carrier family 1 (member 4), solute carrier family 6 (member 8), tetraspan 1, transporter 1 ATP-binding cassette sub-family B (MDR/TAP) and Type I transmembrane receptor (seizure-related protein), with an antibody or binding portion thereof specific for said protein.
An antibody or binding portion of an antibody that specifically binds a protein found in lung tissue, wherein the protein is selected from the group consisting of over expressed in lung of hypothetical protein, amino acid transporter 2, carboxypeptidase M, and putative G-protein coupled receptor.
A method of lung cancer treatment comprising blocking an over expressed protein selected from the group consisting of over expressed in lung of hypothetical protein, amino acid transporter 2, carboxypeptidase M, and putative G-protein coupled receptor, with an antibody or binding portion thereof specific for said protein.
An antibody or binding portion of an antibody that specifically binds to a protein found in colon tissue, wherein the protein is selected from the group consisting of hypothetical protein (colon), cadherin, formyl peptide receptor 1, AE-binding protein 1, solute carrier family 21 (organic anion transporter) member 12, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I), Type I transmembrane protein Fn14, hypoxia-inducible protein 2, alpha-2-glycoprotein 1 zinc, chitinase 3-like1 (cartilage glycoprotein-39) and triggering receptor expressed on myeloid cells 2.
A method of colon cancer treatment comprising blocking an over expressed protein selected from the group consisting of hypothetical protein (colon), cadherin, formyl peptide receptor 1, AE-binding protein 1, solute carrier family 21 (organic anion transporter) member 12, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I), Type I transmembrane protein Fn14, hypoxia-inducible protein 2, alpha-2-glycoprotein 1 zinc, chitinase 3-like1 (cartilage glycoprotein-39) and triggering receptor expressed on myeloid cells 2.
An antibody or binding portion of an antibody that specifically binds to a protein found in kidney tissue, wherein the protein is selected from the group consisting of scavenger receptor class B, adenosine receptor A3, CD97 antigen, APO E-C2 gene, basement membrane-induced gene, integrin alpha 5 (fibronectin receptor, alpha polypeptide), peptide transporter 3, hypothetical protein FLJ22341, solute carrier family 16 (monocarboxylic acid transporters), interleukin 10 receptor alpha, FXYD domain-containing ion transport regulator 5, retinoic acid receptor responder (tazarotene induced) 2, integrin alpha X (antigen CD11C (p150), alpha polypeptide), sema domain seven thrombospondin repeats (type 1 and type 1-like) transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 5B, guanylate binding protein 1 interferon-inducible 67 kD, leukocyte immunoglobulin-like receptor subfamily B, discoidin domain receptor family member 2, caveolin 1 caveolae protein 22 kD, chloride intracellular channel 1, CD36 antigen (collagen type I receptor, thrombospondin recep), small inducible cytokine A4 (homologous to mouse Mip-1b), lysosomal-associated multispanning membrane protein-5, integrin beta 2 antigen CD18 (p95) lymphocyte funtion-assoc, chemokine (C-X-C motif) receptor 4 (fusin), CD2 antigen (p50) sheep red blood cell receptor and epithelial membrane protein 3.
A method of kidney cancer treatment comprising blocking an over expressed protein selected from the group consisting of scavenger receptor class B, adenosine receptor A3, CD97 antigen, APO E-C2 gene, basement membrane-induced gene, integrin alpha 5 (fibronectin receptor, alpha polypeptide), peptide transporter 3, hypothetical protein FLJ22341, solute carrier family 16 (monocarboxylic acid transporters), interleukin 10 receptor alpha, FXYD domain-containing ion transport regulator 5, retinoic acid receptor responder (tazarotene induced) 2, integrin alpha X (antigen CD11C (p150), alpha polypeptide), sema domain seven thrombospondin repeats (type 1 and type 1-like) transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 5B, guanylate binding protein 1 interferon-inducible 67 kD, leukocyte immunoglobulin-like receptor subfamily B, discoidin domain receptor family member 2, caveolin 1 caveolae protein 22 kD, chloride intracellular channel 1, CD36 antigen (collagen type I receptor, thrombospondin recep), small inducible cytokine A4 (homologous to mouse Mip-1b), lysosomal-associated multispanning membrane protein-5, integrin beta 2 antigen CD18 (p95) lymphocyte funtion-assoc, chemokine (C-X-C motif) receptor 4 (fusin), CD2 antigen (p50) sheep red blood cell receptor and epithelial membrane protein 3.
Dependencies are inferred from the claim text.