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AssigneeCorixa Corporation
InventorsAlexander Gaiger, Paul A. Algate, Jane Mannion, Marc Retter
Estimating the term…
Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
An isolated polynucleotide encoding a protein less than about 300 amino acids comprising a sequence selected from the group consisting of:
An oligonucleotide that hybridizes to nucleotides 1-630 of the sequence recited in SEQ ID NO:9600 under moderately stringent conditions.
An isolated polynucleotide encoding a protein of less than 300 amino acids comprising a sequence selected from the group consisting of:
An isolated T cell population, comprising T cells prepared according to the method of claim 26.
A composition comprising a first component selected from the group consisting of physiologically acceptable carriers and immunostimulants, and a second component selected from the group consisting of:
A method for stimulating an immune response in a patient, comprising administering to the patient a composition of claim 28.
Dependencies are inferred from the claim text.