Centrosome proteins and uses thereof
AssigneeUniversity of Massachusetts
InventorStephen J. Doxsey
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Abstract
The invention includes nucleic acids and polypeptides that play important roles in centrosomes and cellular functions involving centrosomes. In addition, the invention encompasses antibodies, ribozymes, antisense nucleic acids, RNAis, and siRNAs that can be used to modulate the function of the nucleic acids and polypeptides of the invention. Such modulation can be useful in detecting, diagnosing, and treating abnormal centrosome function.
Claims32
An isolated nucleic acid comprising SEQ ID NO:1, or a complementary sequence, fragment, or analog thereof.
An isolated nucleic acid consisting of SEQ ID NO:1, or a complementary sequence, fragment, or analog thereof.
An isolated polypeptide encoded by the nucleic acid comprising SEQ ID NO:1, or a degenerate sequence, fragment, or analog thereof.
An isolated polypeptide encoded by the nucleic acid consisting of SEQ ID NO:1, or a degenerate sequence, fragment, or analog thereof.
An isolated polypeptide comprising SEQ ID NO:2, or a fragment or analog thereof.
An isolated polypeptide consisting of SEQ ID NO:2, or a fragment or analog thereof.
A method of reducing cell division, the method comprising administering to a cell an amount of a centriolin modulator effective to disrupting microtubule organization in the cell, wherein cell division is reduced.
A method of reducing cell division, the method comprising administering to a cell an amount of a pericentrin-B modulator effective to disrupt microtubule organization in the cell, wherein cell division is reduced.
A method of treating abnormal centrosome function in a cell, the method comprising administering to the cell an amount of centriolin effective to restore normal centrosome function, wherein normal centrosome function is restored.
A method of treating abnormal centrosome function in a cell, the method comprising administering to the cell an amount of pericentrin-B effective to restore normal centrosome function, wherein normal centrosome function is restored.
Dependencies are inferred from the claim text.