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US 2004/0175700 A1Published application
Method for cohort selection
AssigneeElixir Pharmaceuticals, Inc.
InventorBard J. Geesaman
Life of this patent
Estimating the term…
Abstract
Information for each individual of a first group of individuals and each individual of a second group of individuals is used to select a subset of individuals from the second group. The information can be about a plurality of different biological features. The selection can use a comparison between information for members of the first group and information for members of the subset. It is also possible to compare members of the first group to members of the selected subset with respect to at least one factor. The method can be used to reduce stratification, for example, in the analysis of genetic associations.
Claims50
A method comprising:
- receiving information for each individual of a first group of individuals and each individual of a second group of individuals, wherein the information for each individual comprises indications about a plurality of different biological features;
- selecting a subset of individuals from the second group using a comparison between information for members of the first group and information for members of the subset;
- and
- evaluating the relationship of at least one factor to members of the first group relative to members of the selected subset.
1 more element
A method of evaluating the relationship between a genetic polymorphism and a trait, the method comprising:
- obtaining nucleic acid from each individual of a plurality of individuals, wherein a first group of the individuals are associated with a trait and a second group of individuals are not associated with the trait;
- analyzing the nucleic acid to determine genetic information about a plurality of genetic loci for each individual of the plurality;
- selecting a subset of individuals from the second group based on a comparison between the genetic information for members of the first group and the genetic information for members of the subset;
- and
- evaluating association of a genetic locus of interest and individuals of the first group relative to association of the genetic locus of interest and individuals of the selected subset.
2 more elements
A system comprising:
- a memory that stores information for each individual of a first group of individuals and each individual of a second group of individuals, wherein the information for each individual comprises indications about a plurality of different biological features;
- a communications interface;
- and a processor configured to
- select a subset of individuals from the second group using a comparison between information for members of the first group and information for members of the subset;
- evaluate the relationship of at least one factor to members of the first group relative to members of the selected subset;
- and
- communicate results of the evaluation using the interface.
4 more elements
A method comprising:
- obtaining nucleic acid samples from each individual of a first group of individuals and each individual of a second group of individuals;
- analyzing the nucleic acid samples to determine information about a plurality of genetic markers for each individual of the first and second groups;
- selecting a subset of individuals from the second group using a comparison between the information for members of the first group and the information for members of the subset;
- and
- comparing members of the first group to members of the selected subset with respect to at least one factor.
2 more elements
A method comprising:
- obtaining DNA samples from and information about each individual of a first group of the individuals are associated with a trait;
- analyzing the DNA samples to determine genetic information about a plurality of genetic loci for each individual of the plurality;
- sending the allelic information to a server that stores genetic information for each individual of a second group of individuals;
- and
- receiving information about a subset of individuals selected from the second group of individuals, wherein the subset of individuals is selected using a comparison between the genetic information for members of the first group and genetic information for members of the selected subset.
2 more elements
A server comprising
- a memory that stores allelic information for a plurality of genetic markers for each individual of a first group of individuals;
- and
- software configured to:
- receive genetic information about a plurality of genetic loci for each individual of a plurality of individuals;
- select a subset of individuals from the second group using a comparison between genetic information for members of the plurality of individuals and genetic information for members of the selected subset;
- and
- communicate information about individuals of the subset to a user.
4 more elements
A method of comparing a first and second population of individuals, the method comprising:
- receiving genetic information for the first and second populations of individuals, the genetic information including information about a plurality of genetic markers for each of the individuals, the plurality including markers located on at least four different chromosomes and at least twenty different markers;
- and
- returning a scalar value that is a function of the marker distribution for the first and second population and the degree of covariance among the genetic markers.
A method of performing a controlled study, the method comprising:
- identifying a first and second subset of individuals from the plurality of individuals by comparing occurrences of a plurality of genetic markers among individuals of the first and second subsets;
- and
- subjecting the first subset of individuals to a first condition and the second subset of individuals to a second condition.
A machine readable medium having encoded thereon information comprising:
- a first list of records;
- a second list of records, wherein each record of the first and second list corresponds to a genome and comprises genetic information about each of a plurality of genetic markers in the genome;
- and
- information describing a relationship between records of the first list and records of the second list, wherein the relationship is a function of the genetic information for at least a subset of the genetic markers, the markers of the subset including markers on at least two different chromosomes, and covariance of genetic markers of the subset between records of each list.
1 more element
Dependencies are inferred from the claim text.