Immunization of fish with plant-expressed recombinant proteins
AssigneesProdi Gene, Inc., Novartis AG
InventorsLinda Bootland, Katherine Beifuss
Life of this patent
Estimating the term…
Abstract
Plants are produced that express an amino acid sequence that, when administered to a fish, produce an antigenic or immune response in the fish. The amino acid sequence in one embodiment is an antigen from an organism that causes pathology in fish. The plant tissue may be fed to the fish, or mixed with other materials and fed to fish, or extracted and administered to the fish.
Claims23
A plant comprising a recombinant nucleotide sequence encoding an amino acid sequence which, when administered to a fish, results in an antigenic or immunogenic response in said fish.
A composition for administration to a fish, comprising plant material comprising a nucleotide sequence encoding an amino acid sequence which, when administered to a fish, results in an antigenic or immunogenic response in said fish.
A method of producing a composition for administration to a fish, comprising transforming a plant with a nucleotide sequence encoding an amino acid sequence which, when administered to a fish, results in an antigenic or immunogenic response in said fish.
A method of producing a composition for administration to a fish comprising providing biomass from a plurality of plants, of which at least certain plants comprise a heterologous nucleotide sequence encoding an amino acid sequence which, when administered to a fish, results in an antigenic or immunogenic response in said fish, wherein the nucleotide sequence is operably linked to a promoter to effect expression of the protein by the certain plants.
A method of inducing an immune response in fish comprising feeding fish a plant or plant material from a plant comprising a nucleotide sequence encoding an amino acid sequence which, when administered to a fish, results in an antigenic or immunogenic response in said fish.
Dependencies are inferred from the claim text.