Biodegradable microparticles that stabilize and control the release of proteins
AssigneeBattelle Memorial Institute
InventorsSreedhara Alavattam, Richard S. Brody
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Abstract
Disclosed herein are biodegradable microparticle compositions, and methods for the generation of biodegradable and biocompatible microparticles that stabilize proteins and also control the kinetics of release of proteins over a period of several weeks to several months under physiological conditions.
Claims28
A controlled release formulation comprising:
- a protein mixed with a polysaccharide stabilizer and encapsulated in a biodegradable polymer.
A controlled release formulation comprising:
- a. a protein;
- b. a stabilizer mixed with the protein;
- and
- c. a surfactant coated on the stabilizer protein mixture.
A controlled release formulation comprising:
- a. a protein;
- b. a stabilizer mixed with the protein;
- and
- c. a biodegradable polymer encapsulating the protein stabilizer mixture.
A method for making stabilized protein particles comprising:
- a. providing a solution of protein;
- b. providing a solution of stabilizer;
- c. mixing the solutions;
- and
- d. generating microparticles from the mixture.
A method for making stabilized protein particles comprising:
- a. providing a solution of protein;
- b. providing a solution of stabilizer;
- c. mixing the solutions;
- d. generating microparticles from the mixture;
- and
- e. coating the microparticles with surfactant.
A method for producing stabilized protein particles comprising:
- a. providing source of protein;
- b. providing a source of stabilizer;
- c. mixing the stabilizer and protein, wherein the ratio of stabilizer to protein is an amount effective for stabilizing the protein.
Dependencies are inferred from the claim text.