Controlled release of highly soluble agents
AssigneeControl Delivery Systems, Inc.
InventorPaul Ashton
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Abstract
The invention provides for sustained release formulations for systemic delivery of drugs or other therapeutic agents that are highly soluble in water. Methods of administration of the agents and devices useful for administration are also disclosed. In particular, sustained release formulations are disclosed for the treatment of glaucoma, including methods and devices suitable for the administration of the formulations.
Claims67
A sustained-release formulation, comprising:
- an inner core comprising a therapeutically effective amount of at least one agent, wherein the at least one agent is optionally a free base or a protonated acid, said at least one agent having a solubility in aqueous solution of about 10 mg/ml or less;
- and
- an outer polymer skin covering at least a portion of the inner core.
A drug delivery device comprising:
- a substrate having a surface, and
- a sustained-release formulation adhered to the surface, the sustained release formulation comprising an inner core having a therapeutically effective amount of at least one agent, wherein the at least one agent is a free base or a protonated acid, and has solubility in water that is about 10 mg/ml or less, and an outer polymer skin covering at least a portion of the inner core.
A method of providing sustained-release administration of a highly soluble agent, comprising:
- providing a therapeutically effective amount of at least one agent, wherein said at least one agent is either a free base or a protonated acid, said at least one agent having a solubility in water that is about 10 mg/ml or less,
- forming a sustained-release formulation having an inner core comprising the at least one agent, wherein the inner core is covered at least in part by an outer polymer skin;
- providing the sustained-release formulation in a pharmaceutically acceptable carrier;
- and
- administering the sustained-release formulation to a patient.
A method of treating glaucoma comprising:
- providing a therapeutically effective amount of a free base of a highly water soluble salt of at least one agent that is effective in the treatment of glaucoma,
- forming a sustained-release formulation having an inner core comprising the free base, wherein the inner core is covered at least in part by an outer polymer skin;
- providing the sustained release formulation in a pharmaceutically acceptable carrier;
- and
- administering the sustained release formulation to a patient having glaucoma.
Dependencies are inferred from the claim text.