Medicinal composition
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorYuso Tomohira
Life of this patent
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Abstract
The present invention provides a medicinal composition that exhibits excellent storage stability and, even over long-term storage, little change in the release rate of the pharmacologically active substance contained therein. The medicinal composition of the invention prepared by dissolving or dispersing a pharmacologically active substance and a pH-independent water-insoluble polymer in a molten low-melting substance, and which can be prepared by spraying a liquid substance, obtained by dissolving or dispersing the pharmacologically active substance in a molten mixture comprising the low-melting substance and the pH-independent water-insoluble polymer, and then cooling the liquid substance.
Claims16
A medicinal composition prepared by dissolving or dispersing a pharmacologically active substance and a pH-independent water-insoluble polymer in a molten low-melting-point substance.
A medicinal composition prepared by dissolving or dispersing a pharmacologically active substance in a molten mixture containing a low-melting-point substance and a pH-independent water-insoluble polymer.
A medicinal composition prepared by spraying a liquid substance obtained by dissolving or dispersing a pharmacologically active substance in a molten mixture containing a low-melting-point substance and a pH-independent water-insoluble polymer, and cooling the sprayed liquid substance.
A medicinal composition comprising a low-melting-point substance, a pH-independent water-insoluble polymer and a pharmacologically active substance, wherein the pH-independent water-insoluble polymer and the pharmacologically active substance are independently and uniformly dispersed in each particle of the low-melting-point substance in a molecular state or a fine-particle state.
A medicinal composition comprising a low-melting-point substance, a pH-independent water-insoluble polymer and a pharmacologically active substance, wherein the pharmacologically active substance is uniformly dispersed in a molecular state or a fine-particle state in each particle of either a mixture or a dispersed substance containing the low-melting-point substance and the pH-independent water-insoluble polymer.
A method for preparing a medicinal composition comprising the steps of:
- obtaining a molten mixture by dissolving (melting) or dispersing a pH-independent water-insoluble polymer in a molten low-melting-point substance;
- obtaining a liquid substance by dissolving or dispersing a pharmacologically active substance in the molten mixture;
- and
- obtaining particles by spraying and then cooling the liquid substance.
Dependencies are inferred from the claim text.