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OwnerSuresh Kumar Gidwani, Purushottam Sharshikant Singnurkarinventors
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The present invention relates to a simple and easy method for the preparation of solid oral dosages of the combination of metformin and glyburide. Specifically, glyburide is homogenized in an organic solution whereby about 8 to 15% w/w of glyburide goes into solution and form a slurry. The resulted slurry is then sprayed onto pharmaceutical excipients or metformin granules, and the solid oral dosage of metformin and glyburide is formed. The present invention further relates to the solid oral dosages prepared by the disclosed process, and the method of treating non-insulin dependent diabetes by administering to a patient in need thereof a solid oral dosage prepared by the current invention.
A process of producing a solid oral dosage comprising metformin and glyburide, the process comprising the steps of:
A process of making a solid oral dosage form of the combination of metformin and glyburide, comprising:
A solid oral dosage comprising metformin and glyburide, wherein about 8-15% of glyburide by weight is in the soluble form with no detectable size value and the remaining glyburide is in the form of particles with diameters of less than 45 μm.
Dependencies are inferred from the claim text.