Control of compactibility through cystallization
OwnerOmar Leopold Sprockel, Chiajen Lai +4inventors
InventorsOmar Leopold Sprockel, Chiajen Lai, Robert P Discordia, Chenkou Wei, Sanjeev H Kothari, Soojin Kim
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Abstract
The invention is directed toward a method for increasing the compactability of an active ingredient by determining the crystallization parameters of the active ingredient that affect compactability; and controlling the crystallization parameters to achieve increased compactability.
Claims20
A method for increasing the compactability of an active ingredient comprising determining the crystallization parameters of the active ingredient that affect compactability;
- and controlling said crystallization parameters to achieve increased compactability.
A method for increasing the compactability of an active ingredient comprising the steps of
- determining the desired compactability of the active ingredient;
- evaluating the compactability of the active ingredient;
- determining the crystallization parameters of the active ingredient that affect compactability;
- controlling said crystallization parameters to produce the active ingredient having said desired compactibility.
A process for producing a solid dosage form having a high active ingredient drug load comprising determining the crystallization parameters of the active ingredient that affect the compactability;
- controlling said crystallization parameters to achieve increased compactability;
- compacting the active ingredient into the solid dosage form.
Dependencies are inferred from the claim text.