Enhanced parmacokinetic profile of hydrophobic substances

A method for administration of a hydrophobic substance to a mammal, the method comprising selectively delivering the substance to the dermis of the mammal to obtain systemic absorption of the substance from the dermis.

37 The method of claim 36, wherein the improved pharmacokinetic parameter comprises increased bioavailability of the substance.

A method for administration of a hydrophobic substance to a mammal, the method comprising selectively delivering the substance to the dermis of the mammal wherein systemic absorption of the substance from the dermis is obtained.

71 The method of claim 70 wherein the at least one hollow needle comprises an array of microneedles.

The method of claim 71 wherein the substance is delivered by infusion pump, piezoelectric pump, electromotive pump, electromagnetic pump, Belleville spring, iontophoresis, or sonophoresis.

A method for administration of a hydrophobic substance to a mammal, the method comprising selectively delivering the substance to the dermis of the mammal to achieve a substantially higher bioavailability and/or a substantially higher Cmax and/or a substantially shorter Tmax and/or a substantially shorter Tmax, and/or a substantially greater Ka as compared to that produced upon bolus subcutaneous administration of the substance at an identical dose.

A method for administration of a hydrophobic substance to a mammal, the method comprising selectively delivering the substance to the dermis of the mammal wherein a substantially higher bioavailability and/or a substantially higher Cmax and/or a substantially shorter Tmax and/or a substantially shorter Tlag, and/or a substantially greater Ka is produced as compared to that produced upon bolus subcutaneous administration of the substance at an identical dose.