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US 2004/0175394 A1Published application
Prevention and treatment of amyloidogenic disease
AssigneeNeuralab Limited
InventorDale B. Schenk
Life of this patent
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
Claims72
A method of therapeutically treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide in a regime effective to induce an immune response comprising antibodies to the Aβ peptide and thereby therapeutically treat the disease in the patient;
- and
- monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ binding specificity.
A method of prophylaxis of a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide in a regime effective to induce an immune response comprising antibodies to the Aβ peptide and thereby effect prophylaxis of the disease in the patient;
- and
- monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ binding specificity.
Dependencies are inferred from the claim text.