Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and imunological therapies based thereon

Abstract

A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain apparent “intronic” sequences. In still a further enbodiment, genetic engineering permits the construction of the “intronic” sequences to yield a useful coding sequence for expression of mature Polistinae venom enzyme proteins.

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