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AssigneePluschke, Gerd et al.
InventorsGerd Pluschke, Markus S. Mueller, John A. Robinson, Rinaldo Zurbriggen, Annabelle Freund-Renard
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The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
An immunostimulatory composition comprising the epitope of SEQ ID NO:
An immunostimulatory composition comprising the epitope of SEQ ID NO:
An immunostimulatory composition comprising the epitope of SEQ ID NO:
An immunostimulatory composition comprising the epitope of SEQ ID NO:
An immunostimulatory composition comprising the epitopes of SEQ ID NO:
An immunostimulatory composition comprising at least two epitopes selected from the group consisting of SEQ ID NO:
An immunostimulatory composition comprising the polypeptide of SEQ ID NO:
An immunostimulatory composition comprising the polypeptide of SEQ ID NO:
An immunostimulatory composition comprising the polypeptide of SEQ ID NO:
Dependencies are inferred from the claim text.