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AssigneeBotulinum Toxin Research Associates, Inc.
InventorGary Borodic
Estimating the term…
Botulinum toxin has been shown to be useful for the treatment of pain when administered for cervical dystonia. Given efficacy for pain relief in regional dystonia, further expanded applications have included myofascial pain, muscle tension headaches, and other forms of headache syndromes. The application in headache practice has expanded to migraine as well as certain secondary headache syndromes. Although multiple case reports involving the use of botulinum toxin have shown promise in its utility for the treatment of primary pain syndromes, to date, controlled trials have failed to consistently and more definitively prove utility. Described herein is a method for selection of patients with headache syndromes more likely to respond to botulinum administration. The method involves identifying coincident diseases and signs within the patient's medical history, and selecting such patients for induction into clinical studies for pain or preferential primary treatment of pain using a botulinum based pharmaceutical.
A method of selecting a subject for the treatment of pain with botulinum toxin, comprising the step of identifying a subject suffering from a pain syndrome and atopic disease, wherein the identification of a subject with a pain syndrome and atopic disease is predictive of increased responsiveness to the treatment of pain with botulinum toxin.
A method of identifying a subject with increased responsiveness to treating a pain disorder with botulinum toxin, comprising the step of screening a population of subjects to identify those subjects that suffer from a pain disorder and atopic disease, wherein the identification of a subject with a pain syndrome and atopic disease is predictive of increased responsiveness to the treatment of pain with botulinum toxin.
A method of selecting a subject for the treatment of pain with botulinum toxin, comprising the step of identifying a subject suffering from a pain syndrome that exhibits geste antagoniste phenomenon, wherein the identification of a subject with a pain syndrome that exhibits geste antagoniste phenomenon is predictive of increased responsiveness to the treatment of pain with botulinum toxin.
A method of identifying a subject with increased responsiveness to treating a pain disorder with botulinum toxin, comprising the step of screening a population of subjects to identify those subjects that suffer from a pain disorder and that exhibit geste antagoniste phenomenon, wherein the identification of a subject with a pain syndrome that exhibit geste antagoniste phenomenon is predictive of increased responsiveness to the treatment of pain with botulinum toxin.
Dependencies are inferred from the claim text.