Selected antibody compositions and methods for binding to aminophospholipids
AssigneeBoard of Regents, The University of Texas System
InventorsPhilip E. Thorpe, Sophia Ran
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Abstract
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
Claims19
A composition comprising monoclonal antibody 3G4, or an antigen-binding region or immunoconjugate thereof, wherein said monoclonal antibody is produced by hybridoma ATCC PTA 4545 and binds to the aminophospholipid, phosphatidylserine.
Monoclonal antibody 3G4 produced by hybridoma ATCC PTA 4545.
A method for treating an animal having a vascularized tumor, comprising administering to said animal a therapeutically effective amount of a composition comprising monoclonal antibody 3G4, or an antigen-binding region or immunoconjugate thereof, wherein said monoclonal antibody is produced by hybridoma ATCC PTA 4545 and binds to the aminophospholipid, phosphatidylserine.
Dependencies are inferred from the claim text.