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US 2004/0175377 A1Published application
Agent and method for reducing intraocular pressure
OwnerDonna M. Peters, Paul L. Kaufmaninventors
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Abstract
A method for reducing cell contacts and matrix organization in trabecular meshwork of a human or nonhuman eye includes the step of administering a suitable peptide having a sequence found in the Hep II domain of fibronectin where the peptide has an ability to disrupt cell contacts and matrix formation. A result of the disruption is reduced intraocular pressure in the treated eye.
Claims6
A method for disrupting cell contacts and matrix formation in trabecular meshwork of a human or nonhuman eye, the method comprising the steps of:
- administering to the trabecular meshwork an amount of a peptide sufficient to reduce cell contacts and matrix organization, the peptide comprising amino acid sequences IDAPS and PRARI.
A method for reducing intraocular pressure in a human or nonhuman eye, the method comprising the step of:
- administering to the trabecular meshwork an amount of a peptide sufficient to reduce cell contacts and matrix organization, the peptide comprising amino acid sequences IDAPS and PRARI.
Dependencies are inferred from the claim text.