Introducing a biological material into a patient
OwnerOron Yacoby-Zeeviinventor
Life of this patent
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Abstract
A biological preparation is provided and includes a biological material and a purified, natural or recombinant, extracellular matrix degrading enzyme being externally adhered thereto.
Claims37
An in vivo method of repairing a tissue, the method comprising:
- (a) providing cells capable of proliferating and differentiating in vivo to form said tissue or a portion thereof, said cells having a purified extracellular matrix degrading enzyme externally adhered thereto, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said cells, so as to enhance extravasation, implantation, transplantation, invasion and/or migration of said cells in vivo;
- and
- (b) administering said cells in vivo.
An in vivo method of implanting a tissue or a portion thereof, the method comprising:
- (a) externally adhering to the tissue or the portion thereof a purified, natural or recombinant, extracellular matrix degrading enzyme, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said tissue, so as to enhance implantation or transplantation thereof;
- (b) implanting said tissue or the portion thereof in vivo.
An in vivo method of cell transplantation, the method comprising:
- (a) providing transplantable cells, said cells having a purified extracellular matrix degrading enzyme externally adhered thereto, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said cells, so as to enhance extravasation, implantation, transplantation, invasion and/or migration of said cells in vivo:
- and
- (b) administering said cells in vivo.
A somatic gene therapy method of in vivo introduction of genetically modified cells expressing a therapeutic protein, the method comprising:
- (a) providing the genetically modified cells expressing the therapeutic protein having a purified extracellular matrix degrading enzyme externally adhered thereto, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said cells, so as to enhance extravasation, implantation, transplantation, invasion and/or migration of said cells in vivo;
- and
- (b) administering said cells in vivo.
A method of delivering a biological material across a biological blood barrier, the method comprising
- (a) externally adhering to the biological material a purified, natural or recombinant, extracellular matrix degrading enzyme, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said material, so as to enhance extravasation, implantation, transplantation, invasion and/or migration of said material in vivo;
- and
- (b) administering the biological material in vivo.
A method of delivering cells across a biological blood barrier, the method comprising:
- (a) genetically modifying the cells to express and extracellularly present or secrete a purified extracellular matrix degrading enzyme, thereby increasing the natural amount of said extracellular matrix degrading enzyme externally adhered to said cells, so as to enhance extravasation, implantation, transplantation, invasion and/or migration of said cells in vivo;
- and
- (b) administering the cells in vivo.
Dependencies are inferred from the claim text.