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AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsShiro Takahara, Enyu Imai, Yoshitaka Isaka
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The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys.
A method for introducing a desired gene into an injection area through a vascular system or a ureter of a desired organ, said method comprising the steps of injecting an aqueous solution containing an expression vector comprising the desired gene into the vascular system or the ureter of the target organ, and introducing the expression vector into the injection area.
A method for suppressing organ rejection following transplantation, comprising the steps of:
A method for achieving long-term survival of a transplanted organ, comprising the steps of:
Dependencies are inferred from the claim text.