US 2004/0175365 A1 · Methods and reagents for vaccination which generate a CD8 T cell immune response

Abstract

New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.

Claims20

Dependent claims

A method for generating a CD8+ T cell immune response in a human against melanoma comprising administering to said human at least one dose of each of the following:

(i) a priming composition comprising a source of one or more CD8+ T cell epitopes of melanoma;
and
(ii) a boosting composition comprising a source of one or more CD8+ T cell epitopes of melanoma, including at least one CD8+ T cell epitope which is the same as a CD8+ T cell epitope of the priming composition, wherein the source of CD8+ T cell epitopes is a non-replicating or replication-impaired recombinant poxvirus vector in the human;
with the proviso that if the source of epitopes in (i) is a viral vector, the viral vector in (ii) is derived from a different virus.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/833,439Filed 28 Apr 2004

Priority

GB GB9711957.29 Jun 1997

Published

9 Sep 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification39 codes

C12N 15/86
For animal cells: viral vectors
A61K 38/1709
From vertebrates: from mammals
A61K 39/0011
Vertebrate antigens: cancer antigens
A61K 39/015
Protozoa antigens: hemosporidia antigens, e.g. Plasmodium antigens

Family

Application09/454,204Continuation · filed 9 Dec 1999

Application09/454,204Division · filed 9 Dec 1999

Application10/653,624Continuation · filed 2 Sep 2003

Application10/653,624Division · filed 2 Sep 2003

Application10/686,943Continuation · filed 16 Oct 2003

Application10/833,439Continuation · filed 28 Apr 2004

US 2004/0131594 A1Published application

US 2004/0213799 A1Published application

US 6,663,871 B1Related patent

US 7,514,087 B2Related patent

US 2004/0175365 A1This patent

From the US filing history. Foreign family members aren’t listed.

Methods and reagents for vaccination which generate a CD8 T cell immune response

Life of this patent

Methods and reagents for vaccination which generate a CD8 T cell immune response

Life of this patent

Abstract

Claims20