Application of a bioactive agent to a delivery substrate
OwnerIddys D. Figueroa, Vanessa I. Chinea +5inventors
InventorsIddys D. Figueroa, Vanessa I. Chinea, Orlando Ruiz, Douglas A. Sexton, Winthrop D. Childers, James W. Ayres, John Stephen Dunfield
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Abstract
A method of controlling a dissolution rate of a bioactive agent includes selecting a desired dot size corresponding to a target dissolution rate, and applying a bioactive agent to a delivery substrate in drops of solution configured to form dots having the desired dot size on the delivery substrate.
Claims48
A method of controlling a dissolution rate of a bioactive agent, the method comprising:
- selecting a target dissolution rate;
- applying a bioactive agent to a delivery substrate as a plurality of substantially uniformly sized dots to attain the selected target dissolution rate.
A method of controlling a dissolution rate of a bioactive agent, the method comprising:
- selecting a desired dot size corresponding to a target dissolution rate;
- applying a bioactive agent to a delivery substrate in drops of solution configured to form dots having the desired dot size on the delivery substrate.
A bioactive dosage form, comprising:
- a delivery substrate;
- and
- a plurality of dots of bioactive agent on the delivery substrate sized to achieve a target dissolution rate.
A bioactive agent application system, comprising:
- a nozzle;
- an ejector associated with the nozzle, wherein the nozzle and associated ejector are collectively configured to selectively eject the bioactive agent in drops of solution configured to form dots having a dot size corresponding to a target dissolution rate.
A method of controlling a dissolution rate of a bioactive agent, the method comprising:
- setting an application parameter based on a target dissolution rate;
- and
- applying a bioactive agent to a delivery substrate according to the application parameter to achieve the target dissolution rate.
A bioactive dosage form, comprising:
- a delivery substrate;
- and
- a bioactive agent that is applied to the delivery substrate according to an application parameter selected to achieve a target dissolution rate.
A bioactive agent application system, comprising:
- a depositing subsystem configured to fire a plurality of drops including a bioactive agent onto a delivery substrate according to at least one application parameter selected to achieve a target dissolution rate.
Dependencies are inferred from the claim text.