Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
AssigneeCalcitec, Inc.
InventorsJiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen, Kuan-Liang Lin, I-Chang Wang
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Abstract
A tetracalcium phosphate (TTCP) particle for use in preparing a fast-setting, bioresorbable calcium phosphate cement is disclosed. The TTCP particle has a basic calcium phosphate whiskers on a surface thereof; the basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and having a length up to about 5000 nm and a width up to about 500 nm. The basic calcium phosphate whiskers are substantially free of a hydroxyapatite phase and mainly composed of TTCP phase.
Claims18
A tetracalcium phosphate (TTCP) particle comprising basic calcium phosphate whiskers on a surface of said TTCP particle;
- said basic calcium phosphate whiskers having a length up to about 5000 nm and a width up to about 500 nm, said basic calcium phosphate whiskers having a Ca/P molar ratio greater than 1.33, and said basic calcium phosphate whiskers having a non-stoichiometric chemical composition.
A process for preparing a tetracalcium phosphate (TTCP) powder comprising TTCP particles comprising basic calcium phosphate whiskers on surfaces of said TTCP particles, said process comprising the following steps:
- a) mixing a TTCP powder with a whisker-inducing solution so that basic calcium phosphate whiskers start to grow on surfaces of TTCP particles of said TTCP powder;
- b) terminating the growth of said calcium phosphate whiskers by drying the whisker-inducing solution in the mixture, so that said calcium phosphate whiskers have a length up to about 5000 nm and a width up to about 500 nm, said basic calcium phosphate whiskers have a Ca/P molar ratio greater than 1.33, and said basic calcium phosphate whiskers have a non-stoichiometric chemical composition.
Dependencies are inferred from the claim text.