US 2004/0172666 A1 · Transgenic birds and method of producing protein using same

Abstract

The invention has a object to provide a G0 transgenic chimera bird which can efficiently accumulate the useful protein in eggs of a female bird in which the protein is expressed in an oviduct-specific manner and can accumulate even a toxic protein in eggs with no ill effect for birds, and a transgenic bird and a method of producing them. The above object can be attained by providing a G0 transgenic chimera bird and transgenic bird obtained by introducing a replication-defective retrovirus vector coding for a useful protein by an oviduct-specific expression promoter.

Claims16

Dependent claims

A method of producing a protein,

which comprises producing said protein into eggs laid by a female G1 transgenic bird, a female transgenic bird descended therefrom, or a female G0 transgenic chimera bird,
said female G1 transgenic bird being obtained through the following steps:
a) introducing a replication-defective retrovirus vector coding for the protein under the control of a promoter expressible in an oviduct-specific manner into fertile eggs of a bird,
b) allowing the eggs to hatch to give the G0 transgenic chimera bird and
c) mating one of the G0 transgenic chimera birds with another one of the G0 transgenic chimera birds or with a wild type counterpart bird.

2 more elements

Dependencies are inferred from the claim text.

Transgenic birds and method of producing protein using same

Life of this patent

Transgenic birds and method of producing protein using same

Life of this patent

Abstract

Claims16