Apparatus and method for an ultrasonic probe used with a pharmacological agent

An ultrasonic medical device for destroying a biological material comprising:

• a catheter having a proximal end, a distal end and a plurality of fenestrations along a longitudinal axis of the catheter;
• an ultrasonic probe inserted into the catheter;
• and
• a pharmacological agent delivered through the catheter to enhance a biological material destroying effect of the ultrasonic probe vibrating in a transverse mode along a portion of a longitudinal axis of the ultrasonic probe and a probe tip.

A method of ablating a biological material comprising:

• delivering a catheter into a vasculature;
• inserting an ultrasonic probe into the catheter, the ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween;
• releasing a pharmacological agent through the catheter, the pharmacological agent moving through a plurality of fenestrations located along the catheter to dissolve the biological material;
• extending a section of the longitudinal axis of the ultrasonic probe beyond a distal end of the catheter;
• and
• activating an ultrasonic energy source coupled to the ultrasonic probe to generate an ultrasonic energy that produces a transverse ultrasonic vibration of the ultrasonic probe;
• and
• ablating the biological material adjacent to the section of the longitudinal axis of the ultrasonic probe and a probe tip.

A method of destroying a biological material comprising:

• delivering a catheter into a vasculature;
• inserting an ultrasonic probe into the catheter, the ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween;
• releasing a pharmacological agent through a plurality of fenestrations along the catheter to dissolve the biological material;
• exposing a section of the longitudinal axis of the ultrasonic probe;
• and
• activating an ultrasonic energy source coupled to the ultrasonic probe to generate an ultrasonic energy;
• and
• vibrating in a transverse mode at least the section of the longitudinal axis of the ultrasonic probe and a probe tip to destroy the biological material.