N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

A compound of the formula:

• 1588
• and pharmaceutically acceptable salts thereof wherein
• m is 0-5;
• B is aryl or heteroaryl optionally substituted with one or two groups independently selected from R6, R′6, R″6 and R′″6, or
• B is cycloalkyl or heterocycloalkyl optionally substituted with one, two, three, four, five, six, seven or eight groups independently selected from R6a, R6b, R′6a, R′6b, R″6a, R″6b, R′″6a and R′″6b;
• C1-C8 alkyl, C2-C7 alkenyl or C2-C7 alkynyl, each of which is optionally substituted with one, two or three groups selected from —NRR′, —SR, —CN, —OCF3, —CF3, —CONRR′, —CO2R, —SO2NRR′, —O—P(═O)(OR)(OR′), —N(R)—C(═O) (R′), —N(R) (SO2R′), —SO2R, —C(═O)R, —NO2, halogen, —(CH2)0-4-aryl, and —(CH2)0-4-heteroaryl, or
• R and R′ independently are —H, —(C1-C10) alkyl, —(CH2)0-4—Raryl, —(CH2)0-4—Rheteroaryl, —(CH2)0-4—Rheterocyclyl, or
• C2-C7 alkenyl or C2-C7 alkynyl, each of which is optionally substituted with one, two or three substituents selected from the group consisting of halogen, —OH, —SH, —CN, —CF3, C1-C3 alkoxy, amino, mono- or dialkylamino, and C1-C6 alkyl, or
• —(CH2)0-4—C3-C7 cycloalkyl optionally substituted with one, two or three substituents selected from the group consisting of halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, mono- or dialkylamino, and C1-C6 alkyl;
• benzyl where the phenyl ring is optionally substituted with 1-3 groups independently selected from halogen, —OH, —SH, —C≡N, mono or dialkylamino, C1-C6 alkoxy, or trifluoromethyl;
• R6, R′6, R″6, R′″6, R6a, R6b, R′6a, R′6b, R″6a, R″6b, R′″6a and R′″6b independently are —OR, —NO2, halogen, —CO2R, —C≡N, —NRR′, —SR, —SO2R, —C(═O)R, —OCF3, —CF3, —CONRR′, —SO2NRR′, —O—P(═O)(OR)(OR′), —N(R)(COR′), —N(R)(SO2R′), —(CH2)0-4—CO—NR7R′7, —(CH2)0-4—O—(CH2)0-4—CONRR′, —(CH2)0-4—CO—(C1-C12 alkyl), —(CH2)0-4—CO—(C2-C12 alkenyl), —(CH2)0-4—CO—(C2-C12 alkynyl), —(CH2)0-4—CO—(C3-C7 cycloalkyl), —(CH2)0-4—Raryl, —(CH2)0-4—Rheteroaryl, —(CH2)0-4—Rheterocyclyl, —(CH2)0-4—CO—Raryl, —(CH2)0-4—CO—Rheteroaryl, —(CH2)0-4—CO—Rheterocyclyl, —(CH2)0-4—CO—R10, —(CH2)0-4—CO—O—R11, —(CH2)0-4—SO2—NR7R′7, —(CH2)0-4—SO—(C1-C8 alkyl), —(CH2)0-4—SO2—(C1-C12 alkyl), —(CH2)0-4—SO2—(C3-C7 cycloalkyl), —(CH2)0-4—N(H or R11)—CO—O—R11, —(CH2)0-4—N(H or R11)—CO—N(R11)2, —(CH2)0-4—N(H or R11)—CS—N(R11)2, —(CH2)0-4—N(—H or R11)—CO—R7, —(CH2)0-4—NR7R′7, —(CH2)0-4—R10, —(CH2)0-4—O—CO—(C1-C6 alkyl), —(CH2)0-4—O—P(O)—(O—Raryl)2, —(CH2)0-4—O—CO—N(R11)2, —(CH2)0-4—O—CS—N(R11)2, —(CH2)0-4—O—(R11), —(CH2)0-4—O—(R11)—COOH, —(CH2)0-4—S—(R11), C3-C7 cycloalkyl, —(CH2)0-4—N(—H or R11)-SO2—R7, or —(CH2)0-4—C3-C7 cycloalkyl, or
• C1-C8 alkyl optionally substituted with one, two or three groups independently selected from C1-C6 alkyl, —F, —Cl, —Br, —I, —OR, —NO2, —F, —Cl, —Br, —I, —CO2R, —C≡N, —NRR′, —SR, —SO2R, —C(═O)R, —OCF3, —CF3, —CONRR′, —SO2NRR′, —O—P(═O) (OR) (OR′), —N(R) (COR′), —N(R) (SO2R′), —(CH2)0-4—CO—NR7R′7, —(CH2)0-4—CO—(C1-C12 alkyl), —(CH2)0-4—CO—(C2-C12 alkenyl), —(CH2)0-4—CO—(C2-C12 alkynyl), —(CH2)0-4—CO—(C3-C7 cycloalkyl), —(CH2)0-4—Raryl, —(CH2)0-4—Rheteroaryl, —(CH2)0-4—Rheterocyclyl—(CH2)0-4—CO—Raryl, —(CH2)0-4—CO—Rheteroaryl, —(CH2)0-4—CO—Rheterocyclyl, —(CH2)0-4—CO—R10, —(CH2)0-4—CO—O—R11, —(CH2)0-4—SO2—NR7R′7, —(CH2)0-4—SO—(C1-C8 alkyl), —(CH2)0-4—SO2—(C1-C12 alkyl), —(CH2)0-4—SO2—(C3-C7 cycloalkyl), —(CH2)0-4—N(H or R11) —CO—O—R11, —(CH2)0-4—N(H or R11) —CO—N(R11)2, —(CH2)0-4—N(H or R11) —CS—N(R11)2, —(CH2)0-4—N(—H or R11) —CO—R7, —(CH2)0-4—NR7R′7, —(CH2)0-4—R10, —(CH2)0-4—O—CO—(C1-C6 alkyl), —(CH2)0-4—O—P(O)—(O—Raryl)2, —(CH2)0-4—O—CO—N(R11)2, —(CH2)0-4—O—CS—N(R11)2, —(CH2)0-4—(R11), —(CH2)0-4—O—(R11) —COOH, —(CH2)0-4—S—(R11), C3-C7 cycloalkyl, —(CH2)0-4—N(—H or R11)—SO2—R7, or —(CH2)0-4-C3-C7 cycloalkyl, or
• C2-C7 alkenyl or C2-C7 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from halogen or —OH, or
• C2-C7 alkenyl or C2-C7 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from halogen, C1-C3 alkyl, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino, or
• —(CH2)0-4—O—(C1-C6 alkyl), where the alkyl portion is optionally substituted with one, two, three, four, or five of halogen, or
• any two of R6a, R6b, R′6a, R′6b, R″6a, R″6b, R′″6a and R′″6b together are oxo;
• R7 and R′7 are the same or different and represent —H, —C3-C7 cycloalkyl, —(C1-C2 alkyl)-(C3-C7 cycloalkyl), —(C1-C6 alkyl)-O—(C1-C3 alkyl), —C2-C6 alkenyl, —C2-C6 alkynyl, —C1-C6 alkyl chain with one double bond and one triple bond, or
• —C1-C6 alkyl optionally substituted with —OH or —NH2;
• or;
• —C1-C6 alkyl optionally substituted with one, two or three groups independently selected from halogen;
• or
• heterocyclyl optionally substituted with halogen, amino, mono- or dialkylamino, —OH, —C≡N, —SO2—NH2, —SO2—NH—C1-C6 alkyl, —SO2—N(C1-C6 alkyl)2, —SO2—(C1-C4 alkyl), —CO—NH2, —CO—NH—C1-C6 alkyl, oxo and —CO—N(C1-C6 alkyl)2;
• or
• C1-C6 alkyl optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C1-C6 alkoxy optionally substituted with one, two or three of halogen;
• aryl or heteroaryl, each of which is optionally substituted with halogen, amino, mono- or dialkylamino, —OH, —CE-N, —SO2—NH2, —SO2—NH—C1-C6 alkyl, —SO2—N(C1-C6 alkyl)2, —SO2—(C1-C4 alkyl), —CO—NH2, —CO—NH—C1-C6 alkyl, and —CO—N(C1-C6 alkyl)2;
• or
• C1-C6 alkyl optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C1-C6 alkoxy optionally substituted with one, two or three of halogen;
• R10 is heterocyclyl optionally substituted with one, two, three or four groups independently selected from C1-C6 alkyl;
• R11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, —(CH2)0-2—Raryl, or —(CH2)0-2—Rheteroaryl;
• Raryl is aryl optionally substituted with halogen, amino, mono- or dialkylamino, —OH, —C≡N, —SO2—NH2, —SO2—NH—C1-C6 alkyl, —SO2—N(C1-C6 alkyl)2, —SO2—(C1-C4 alkyl), —CO—NH2, —CO—NH—C1-C6 alkyl, or —CO—N(C1-C6 alkyl)2;
• or
• C1-C6 alkyl optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C1-C6 alkoxy optionally substituted with one, two or three of halogen;
• Rheteroaryl is heteroaryl, each of which is optionally substituted with halogen, amino, mono- or dialkylamino, —OH, —C≡N, —SO2—NH2, —SO2—NH—C1-C6 alkyl, —SO2—N(C1-C6 alkyl)2, —SO2—(C1-C4 alkyl), —CO—NH2, —CO—NH—C1-C6 alkyl, or —CO—N(C1-C6 alkyl)2;
• or
• C1-C6 alkyl optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C1-C6 alkoxy optionally substituted with one, two or three of halogen;
• Rheterocyclyl is heterocyclyl optionally substituted with halogen, amino, mono- or dialkylamino, —OH, —CN, —SO2—NH2, —SO2—NH—C1-C6 alkyl, —SO2—N(C1-C6 alkyl)2, —SO2—(C1-C4 alkyl), —CO—NH2, —CO—NH—C1-C6 alkyl, ═O or —CO—N(C1-C6 alkyl)2;
• or
• C1-C6 alkyl optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —CE-N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three groups independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C3 alkoxy, amino, and mono- or dialkylamino;
• or
• C1-C6 alkoxy optionally substituted with one, two or three of halogen;
• R2 and R3 are independently hydrogen or C1-C6 alkyl;
• or
• R2 and R3 taken together with the carbon atom to which they are attached form a 3 or 4-membered ring;
• RC is hydrogen or phenyl optionally substituted with C1-C3 alkyl, C2-C4 alkynyl, trifluoromethyl, or C1-C2 alkoxy.

A compound of the formula

• 1589
• or a pharmaceutically acceptable salt thereof, wherein
• R30 is selected from the group consisting of phenyl, pyrazolopyrimidinyl, oxa-aza-benzoazulenyl, isoxazolyl, triazolopyridinyl, pyrrolidinonyl, tetrahydrothia-aza-fluorenyl, pyridyl, piperidinyl, dihydrocyclopentaquinolinyl, furyl, naphthothienyl, phthalazinonyl, thiadiazolyl, thienopyrimidinonyl, oxa-diaza-cyclopentanaphthalenyl, dihydrobenzodioxepinyl, chromanonyl, chromenonyl, oxazolidinyl, benzophenone, pyrazinyl mono N-oxide, benzofuranyl, pyrazolyl, -isoxazolyl-phenyl, phenyl-triazolyl, benzimidazolyl, indolyl, phenyl-pyrrolyl, chromanyl, isoquinolinyl, -thienyl-thienyl, benzothienyl, -phenyl-thiadiazolyl, chromanonyl, quinolinyl, -pyrrolyl-C(O)-phenyl, -phenyl-O-phenyl, -phenyl-oxazolyl, -pyrrolidinonyl-phenyl, -phenyl-pyrimidinyl, -phenyl-oxadiazolyl, bicyclo[2.2.1]heptenyl, cyclopentyl, thieno[2,3-b]thiophene, cyclohexyl, -phenyl-imidazolyl, benzoxazole;
• dihydro-1H-indolyl;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• benzo[b] thiophene 1,1-dioxide;
• 2,3-dihydro-benzo[d]isothiazole 1,1-dioxide;
• -phenyl-thiazolyl;
• -phenyl-pyrazolyl, -phenyl-C(O)-piperidyl, -phenyl-C(O)-pyrrolidinyl, -phenyl-isoxazolyl, isoindolyl, purinyl, oxazolyl, thiazolyl, pyridazinonyl, thiazolyl, pyranyl, dihydropyranopyridinyl, diazepanyl, azepanyl, cyclopropyl, dihydronaphthoisoxazolyl, benzoindazolyl, dihydrocyclopentachromenonyl, imidazopyrazolyl, tetrahydrocyclopentachromenonyl, dihydroquinolinonyl, pyridyl N-oxide, isochromanyl, quinazolinonyl, pyrazolopyridinyl, dihydrobenzothiophene dioxide, dihydrofurobenzoisoxazolyl, dihydropyrimidine dionyl, thienopyrazolyl, oxazolyl, tetrahydrocyclopentapyrazolyl, dihydronaphthalenonyl, dihydrobenzofuranonyl, dihydrocyclopentathienyl, tetrahydrocyclopentapyrazolyl, tetrahydropyrazoloazepinyl, indazolyl, tetrahydrocycloheptaisoxazolyl, tetrahydroindolonyl, pyrrolidinyl, thienopyridinyl, dioxodihydrobenzoisothiazolonyl, triazolopyrimidinyl, thienyl, dihydrothienopyrimidinonyl, benzooxadiazolyl, carbazolyl, chromeno[3,4-d]isoxazolyl, chromanonyl, triazolopyridazinyl, oxazolidinyl, -pyrrolyl-(C1-C6 alkyl)-pyridyl, -pyrrolyl-cyclohexyl, pyrrolidinonyl, dihydropyrazolyl, benzooxadiazolyl mono N-oxide, 1-H-pyridazinonyl, -phenyl-dihydro-1-H-pyrazolidinonyl, -phenyl-pyrrolidinyl dione, thienoindolyl, thioxobenzothiazolyl, pyrazolopyridinyl, thiomorpholinyl S-oxide, dihydrofurylbenzisoxazolyl, benzoisothiazolinonyl 1,1-dioxide;
• tetrahydropyrimidinyl dione, tetrahydrothiopyranylindolyl, benzodioxepinyl, -phenyl-pyrrazolidinonyl, dihydronaphthyl, tetrahydronaphthyl, isoindolinyl dione, -imidazole-benzyl, -thiene-dihydrooxazolyl, thienoquinolinyl, -pyrrolidine-phenyl, benzooxazolidinonyl, pyrrolopyridinyl, indanonyl, 1-H-imidazo[1,2-b]pyrazolyl, dihydrocyclopenta[b]thienyl, dihydroindazolonyl, tetrahydropyrazoloazepinyl, tetrahydrobenzofuranonyl, thienopyrazolyl, cyclopenta[c]pyrazolyl, tetrahydrocyclopenta[c]pyrazolyl, tetrahydroquinoxalinyl dione, tetrahydroindazolyl, imidazobenzoxazinyl, -phenyl-dihydropyrrolyl dione, -phenyl-O-benzyl, -phenyl-benzyl, 3′,4′-dihydro-1′H-spiro[[1,3]dioxolane-2,2′-naphthalenyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of
• C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN;
• OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl;
• haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33;
• —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33;
• —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl) (C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33;
• —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N (C1-C6 alkyl) (C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl) thienyl, —(C1-C6 alkyl) furanyl, —S—(C1-C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl) (C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br;
• pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8 cycloalkyl, —O—(C1-C6 alkyl)-R33;
• pyrrole optionally substituted with one or two methyl groups;
• 2,3-dihydro-benzofuran;
• benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl) (C1-C6 alkyl);
• —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, —S—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently CN or OH;
• indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, —(CH2)0-4—SO2-(C1-C10 alkyl) wherein the alkyl group is optionally substituted with OH;
• —NHC(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)NH(C3-C8 cycloalkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —NHC(O)N(C1-C6 alkyl)(C3-C8 cycloalkyl), —(C1-C6 alkoxy)-(C1-C6 thioalkoxy);
• —CO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with phenyl;
• —C(O)-furan;
• and imidazolyl;
• wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms;
• —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl, -pyrrolidinyl-benzyl, —(C1-C6 thioalkoxy)-(C1-C6 alkyl), —C(O)—(C1-C6 alkyl), (C1-C6 alkoxy), —(C2-C6 alkenyloxy), —(C1-C6 alkyl)-CO2—(C1-C6 alkyl), and —C(O)-piperidinyl optionally substituted with C1-C6 alkyl;
• wherein
• the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or
• R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl;
• R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl) (phenyl), N(C1-C6 alkyl) (benzyl);
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl), or (CH2)0-4CN;
• R40 is phenyl, -phenyl-pyridyl, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl wherein the phenyl is optionally substituted with 1, 2, or 3 halogen atoms;
• —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl) (C1-C6 alkyl), —SO2NH2, —SO2NH(C1-C6 alkyl), —SO2N(C1-C6 alkyl) (C1-C6 alkyl), CN, —(CH2)0-4—(C3-C8 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl), —(C1-C4 alkyl)-R33, C1-C10 alkyl, C2-C8 alkenyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —(CH2)0-4—C(O)NH2, —(CH2)0-4—C(O)NH(C1-C6 alkyl), —(CH2)0-4—C(O)N(C1-C6 alkyl) (C1-C6 alkyl), naphthyl, tetrahydronaphthyl, dihydronaphthyl, —(CH2)0-4-imidazolyl, —(CH2)0-4-pyrrolidinyl, oxazolidinone 3,4-dihydro-benzo[e][1,2]oxathiine 2,2-dioxide, pyrimidinyl, 3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxide, pyridyl, or pyrimidyl, alkoxyalkyl, -phenyl-benzothienyl, -phenyl-cyclohexyl, -phenyl-cyclopentyl, -phenyl-(C1-C6 alkyl)-cyclopentyl, -phenyl-(C1-C6 alkyl) -cyclohexyl, -phenyl-oxazolyl, furanyl, tetrahydrofuranyl, 7-oxa-bicyclo[2.2.1]heptyl;
• -dihydro-1-H-pyrazolidinone-phenyl;
• -phenyl-bicyclo[2.2.1] heptyl;
• imidazo[2,1-b][1,3]thiazolyl;
• azepanonyl;
• piperidinyl, —(C1-C6 alkyl)-piperidinyl;
• bicyclo[2.2.1]heptyl;
• chromanonyl, —(C1-C6 alkyl)-morpholinyl;
• -phenyl-C(O)-piperidinyl;
• tetrahydrothiazolopyridinyl, -pyrrolo-C(O)-pyrrolidinyl;
• -phenyl-C(O)-phenyl;
• -phenyl-O-phenyl;
• -phenyl-O-benzyl;
• -phenyl-tetrahydropyridazinonyl;
• and -phenyl-dihydropyridazinonyl;
• wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C8 alkyl optionally substituted with 1 or two groups that are independently CN or OH;
• C1-C6 alkoxy, halo (C1-C8 alkyl), halo (C1-C4 alkoxy), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, CN, —CHO, C1-C4 thioalkoxy, —NHSO2—(C1-C6 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl groups are optionally substituted with 1, 2, or 3 halogens;
• OH;
• —SO2R33;
• R33;
• C2-C8 alkynyl;
• C2-C8 alkenyl;
• thioalkoxyalkyl;
• —SO2—(C1-C10 alkyl);
• —NR31R32;
• —C(O)—NR31R32;
• —OC(O)R33;
• C1-C8 alkanoyl;
• and —(C1-C6 alkyl)-C(O)—(C1-C6 alkoxy), —C(O)—(C1-C6 alkoxy);
• —O—(C1-C6 alkyl)-C(O)NR31R32;
• —CO2—(C1-C6 alkyl);
• R41a and R41 are independently H, cyclohexyl, phenyl, or C1-C6 alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, C1-C4 thioalkoxy, C1-C4 thioalkoxy C1-C6 alkyl;
• or —C1-C6 alkyl-SO2—C1-C6 alkyl;
• R40, R41, and the atom to which they are attached form a C3-C8 cycloalkyl ring which is optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen, —CO2NH2, —CO2NH(C1-C6 alkyl), or —CO2N(C1-C6 alkyl) (C1-C6 alkyl);
• a thiazolyl ring which is optionally substituted with C1-C6 alkyl;
• isoxazolyl ring which is optionally substituted with C1-C6 alkyl;
• phenyl which is optionally substituted with 1, 2, or 3 groups that are independently halogen or C1-C6 alkyl;
• -pyrrolidinyl-benzyl;
• piperidinyl optionally substituted with 1 or 2 groups that are independently —CO2—(C1-C6 alkyl) or —C(O)—(C1-C6 alkyl);
• and
• R42 is H, C1-C6 alkyl optionally substituted with OH;
• benzyl;
• —NHC(O)—(C1-C6 alkyl);
• —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• —CO2—(C1-C6 alkyl);
• —CO2—(benzyl);
• or —C(O)—(C1-C6 alkyl).

A compound of the formula:

• 1591
• or a pharmaceutically acceptable salt thereof, wherein
• R30 is selected from the group consisting of phenyl, pyrazolopyrimidinyl, oxa-aza-benzoazulenyl, isoxazolyl, triazolopyridinyl, pyrrolidinonyl, tetrahydrothia-aza-fluorenyl, pyridyl, piperidinyl, dihydrocyclopentaquinolinyl, furyl, naphthothienyl, phthalazinonyl, thiadiazolyl, thienopyrimidinonyl, oxa-diaza-cyclopentanaphthalenyl, dihydrobenzodioxepinyl, chromanonyl, chromenonyl, oxazolidinyl, purinyl, oxaxolyl, thiazolyl, pyridazinonyl, thiazolyl, pyranyl, dihydropyranopyridinyl, diazepanyl, cyclopropyl, dihydronaphthoisoxazolyl, benzoindazole, dihydrocyclopentachromenonyl, imidazopyrazolyl, tetrahydrocyclopentachromenonyl, dihydroquinolinonyl, pyridyl, isochromanyl, quinazolinonyl, pyrazolopyridinyl, dihydrobenzothiophene dioxide, dihydrofurobenzoisoxazolyl, dihydropyrimidine dionyl, thienopyrazolyl, oxazolyl, tetrahydrocyclopentapyrazolyl, dihydronaphthalenonyl, dihydrobenzofuranonyl, dihydrocyclopentathienyl, tetrahydrocyclopentapyrazolyl, tetrahydropyrazoloazepinyl, indazolyl, tetrahydrocycloheptaisoxazolyl, tetrahydroindolonyl, pyrrolidinyl, thienopyridinyl, dioxodihydrobenzoisothiazolonyl, triazolopyrimidinyl, thienyl, dihydrothienopyrimidinonyl, and benzooxadiazolyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of
• C1-C10 alkyl optionally substituted with phenyl, hydroxy, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 hydroxy groups, —C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 R33 groups, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 R33 groups, —SO2—N(C1-C6 alkyl) (C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 R33 groups, —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —O—(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl) thienyl, —(C1-C6 alkyl) furanyl, —S—(C1-C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl) (C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br, pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C6 cycloalkyl, —O—(C1-C6 alkyl)-R33, benzo[1,2,5]oxadiazole, —C(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl) (C1-C6 alkyl);
• —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-Dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy) -pyridine,
• wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, wherein
• the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or
• R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl;
• R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl)(phenyl);
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl);
• R42 is H, C1-C6 alkyl, benzyl, —NHC(O)—(C1-C6 alkyl), or —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups,
• R55 is cyclohexyl;
• cyclopentyl;
• azepanone;
• phenyl;
• piperidinyl;
• —SO2-phenyl;
• pyrrolidinyl;
• or 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine;
• wherein each is optionally substituted with —C(O)NH2;
• —C(O)NH(C1-C6 alkyl);
• —C(O)N(C1-C6 alkyl) (C1-C6 alkyl);
• C1-C6 alkoxycarbonyl;
• —O—(C1-C6 alkyl)-C(O)NR31R32;
• —(C1-C6 alkyl)-phenyl;
• 4,5-dihydro-2H-pyridazin-3-one;
• C5-C6 cycloalkyl which is optionally substituted with one CN group, phenyloxy wherein the phenyl group is optionally substituted with —NHC(O)C1-C6 alkyl, —N(C1-C6 alkyl)-C(O)C1-C6 alkyl, wherein
• R31, R32 and the nitrogen to which they are attached form a pyrrolidine, piperidine, piperazine, morpholine, or thiamorpholine ring, wherein each ring is unsubstituted or substituted with 1, 2, or 3 groups that are independently OH, C1-C6 alkyl, C1-C6 alkoxy, —(C1-C6 alkyl)-imidazole wherein the imidazole is optionally substituted with 1 or 2 C1-C4 alkyl groups, or hydroxy (C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 phenyl ring, or
• R42, R55 and the nitrogen to which they are attached form a tetrahydroisoquinolinyl, dihydroisoquinolinyl, or isoquinolinyl group which is optionally substituted by 1, 2, 3, or 4 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, CN, OH, and phenyl, wherein the phenyl is optionally substituted with halogen, hydroxyl, C1-C4 alkoxy, and C1-C4 alkyl.

A compound of the formula

• 1592
• or a pharmaceutically acceptable salt thereof, wherein
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl);
• R40 is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isooxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl, —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl) (C1-C6 alkyl), CN, —(C1-C4 alkyl)-(C3-C7 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl, —(C1-C4 alkyl)-R33, C1-C8 alkyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —C(O)NH2, wherein each of the above rings is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, halo (C1-C4 alkyl), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —CHO, —NHSO2—(C1-C4 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl is optionally substituted with 1, 2, or 3 halogens,
• R42 is H, C1-C6 alkyl optionally substituted with OH;
• benzyl;
• —NHC(O)—(C1-C6 alkyl);
• —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• —CO2—(C1-C6 alkyl);
• —CO2-(benzyl);
• or —C(O)—(C1-C6 alkyl);
• R52 is H, phenyl, —NHC(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), OH, C1-C6 alkyl, C1-C6 alkoxy, mono or di(C1-C6 alkyl)amino, —NHC(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with a phenyl, —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl) wherein the alkyl groups are each optionally substituted with a phenyl, —(CH2)0-4—SO2—(C1-C10 alkyl), —NHCO2-benzyl, or —NH2, and
• R60 is -L-V-R65, C1-C8 alkyl, or hydroxy C1-C8 alkyl, wherein the alkyl or hydroxyalkyl groups are optionally substituted with 1 or 2 L-V-R65 groups, wherein
• L is absent, —C(O)—, —CO2—, —C(O)NH—, —C(O)N(C1-C6 alkyl)-, —NHC(O)—, —N(C1-C6 alkyl)-C(O)—, —(CH2)0-4—SO2—(CH2)0-4—(CH2)0-4—O—(CH2)0-4—, —(CH2)0-4—S—(CH2)0-4—, —NHC(O)NH—N(C1-C6 alkyl)C(O)NH—, —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)-, —NHC(O)N(C1-C6 alkyl)-, —NH—, —N(benzyl)-, —N(phenyl)-, —(CH2)0-4—NHSO2—(CH2)0-4-, —N(C1-C6 alkyl)SO2—, —SO2NH—, —SO2N(C1-C6 alkyl)-, or C2-C6 alkenyl;
• or
• V is absent, —(CH2)0-4—C(O)NH—, —(CH2)0-4—C(O)N(C1-C6 alkyl)-, cyclopropyl optionally substituted with 1 or 2 C1-C4 alkyl groups, ═NH, ═NOH, ═N-alkoxy, C1-C8 alkyl optionally substituted with 1 or 2 OH;
• or —CH(phenyl)- wherein the phenyl is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen or OH;
• cyclopentyl;
• cyclohexyl;
• or —CH(phenyl)-;
• R65 is cyclohexyl;
• cyclopentyl;
• phenyl;
• —(C1-C6 alkyl)-phenyl;
• NH2;
• mono or di(C1-C10 alkyl)amino wherein the alkyl group or groups are optionally substituted with 1 or 2 groups that are independently cyclopropyl, phenyl or OH;
• oxadiazolyl;
• triazolopyrimidinyl;
• triazolyl;
• thiadiazolyl;
• 3H-quinazolin-2-onyl;
• pyrimidinyl;
• pyridyl;
• pyridyl N-oxide;
• —(C1-C6 alkyl)-pyridyl;
• piperazinyl;
• phthalazinyl;
• tetrahydro-thiophenyl 1,1-dioxide;
• tetrazolyl;
• C3-C6 cycloalkyl-C1-C6 alkyl;
• —(C1-C4 alkyl)-SO2-(C1-C4 alkyl);
• —SO2—(C1-C6 alkyl);
• benzothiazolyl;
• hexahydro-isoindole-1,3-dionyl;
• benzimidazolyl;
• benzoxazolyl;
• [1,2,4]triazolo[1,5-a]pyrimidinyl;
• [1,2,4]triazolo[4,3-a]pyrimidinyl, thiazolyl;
• thiadiazolyl;
• imidazo[1,2-a]pyridine;
• 3-aza-bicyclo[3.2.2]nonane;
• pyrrolidinonyl;
• diazepanyl;
• benzo[1,2,5]thiadiazolyl;
• —NHSO2-(4-methylphenyl);
• [1,2,4]triazolo[4,3-b]pyridazinyl, benzopyrrolidinonyl;
• morpholinyl;
• thiomorpholinyl;
• thiomorpholinyl S-oxide;
• thiomorpholinyl S,S-dioxide;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• pyrrolidinyl;
• [1,2,4]oxadiazole;
• C1-C10 alkyl;
• isoxazolyl;
• 2,3-dihydro-1H-indolyl;
• quinazolinonyl;
• quinazolinyl;
• piperidyl;
• —CO2—(C1-C6 alkyl);
• dibenzofuranyl;
• dihydroindolinonyl;
• triazolobenzimidazolyl;
• benzotriazolyl;
• tetrahydrobenzofuranonyl;
• benzofuranyl;
• dihydrobenzofuranyl, tetrahydrofuranyl;
• furanyl;
• oxazolopyridinyl;
• tetrahydrobenzothienyl;
• dihydropurinyl dione;
• indolyl;
• thienyl;
• imidazolyl;
• cyclohexanonyl;
• naphthyl;
• tetrahydrothienyl S,S-dioxide;
• chromanyl;
• isoindolinonyl;
• [1,2,4]triazolo[4,3-a]pyrimidinyl;
• -phenyl-oxazolidinonyl;
• 3-oxo-2,3-dihydroimidazo[2,1-b][1,3]thiazolyl;
• dihydrothiazolyl;
• benzodioxinyl;
• 2,3 dihydrobenzimidazolidinonyl;
• tetrahydrocyclopenta[b]chromenonyl;
• 1-H-benzo[g]indazolyl;
• 4,5-dihydronaphtho[2,1-d]isoxazolyl;
• tetraazolo[1,5-b]pyridazinyl;
• pyrrolyl;
• dihydropyrazolidinonyl;
• —NHSO2NH2;
• —N(C1-C6 alkyl)SO2NH2;
• —N(C1-C6 alkyl)SO2NH(C1-C6 alkyl);
• —N(C1-C6 alkyl)SO2N(C1-C6 alkyl) (C1-C6 alkyl);
• —NHSO2NH(C1-C6 alkyl);
• —NHSO2N(C1-C6 alkyl)(C1-C6 alkyl);
• tetrahydrobenzothienyl;
• imidazolidinyl dione;
• diazepanonyl;
• or dihydroanthracenyl dione;
• wherein each of the above is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently
• C1-C6 alkyl, CF3, halogen, phenyl, —(C1-C4 alkyl)-phenyl, —C(O)phenyl, pyrrolidine-dione, C1-C6 alkoxy, —C(O)-furan, —C(O)NH2, —C(O)NH(C1-C6 alkyl), —C(O)N(C1-C6 alkyl) (C1-C6 alkyl),cyclopropyl, —(CH2)0-4-cyclopentyl, benzoxazolyl, pyridine, —NHC(O)—(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl), —C(O)C1-C6 alkyl, —CO2H, —NHSO2—(C1-C8 alkyl), —N(C1-C6 alkyl)SO2—(C1-C8 alkyl), (C1-C6 alkoxy), OH, oxazolyl, (C1-C6 thioalkoxy), or CN.

A compound of the formula wherein

• 1593
• or a pharmaceutically acceptable salt thereof, wherein
• X10 is —O—, —S—, —NH—, —N(C1-C6 alkyl)-, —N(phenyl)-, —N(benzyl)-, —N(CO2—C1-C6 alkyl)-;
• —N(CO2—C1-C6 alkyl-phenyl)-, or haloalkyl;
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl);
• R40 is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isooxazolyl, —C(O) -pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl, —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl) -phenyl, —(C1-C4 alkyl) -phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl) (C1-C6 alkyl), CN, —(C1-C4 alkyl)-(C3-C7 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl, —(C1-C4 alkyl)-R33, C1-C8 alkyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —C(O)NH2, wherein each of the above rings is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, halo (C1-C4 alkyl), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —CHO, —NHSO2—(C1-C4 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl is optionally substituted with 1, 2, or 3 halogens,
• R42 is H, C1-C6 alkyl, benzyl, —NHC(O)—(C1-C6 alkyl), or —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• R52 is H, phenyl, —NHC(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), OH, C1-C6 alkyl, mono or di(C1-C6 alkyl)amino, —NHC(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with a phenyl, —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl) wherein the alkyl groups are each optionally substituted with a phenyl, —(CH2)0-4—SO2—(C1-C10 alkyl), —NHCO2-benzyl, or —NH2, and
• R60 is -L-V-R65, C1-C8 alkyl, or hydroxy C1-C8 alkyl, wherein the alkyl or hydroxyalkyl groups are optionally substituted with 1 or 2 L-V-R65 groups, wherein
• L is absent, —C(O)—, —CO2—, —C(O)NH—, —C(O)N(C1-C6 alkyl)-, —NHC(O)—, —N(C1-C6 alkyl)-C(O)—, —(CH2)0-4—SO2—(CH2)0-4—, (CH2)0-4—O—(CH2)0-4—, —(CH2)0-4—S—(CH2)0-4—, —NHC(O)NH—, N(C1-C6 alkyl)C(O)NH—, —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)-, —NHC(O)N(C1-C6 alkyl)-, —NH—, —N(benzyl)-, —N(phenyl)-, —(CH2)0-4—NHSO2—(CH2)0-4-, —N(C1-C6 alkyl)SO2—, —SO2NH—, —SO2N(C1-C6 alkyl)-, or
• V is absent, —(CH2)0-4—C(O)NH—, —(CH2)0-4—C(O)N(C1-C6 alkyl)-, cyclopropyl optionally substituted with 1 or 2 C1-C4 alkyl groups, ═NH, ═NOH, ═N-alkoxy, C3-C8 alkyl optionally substituted with 1 or 2 OH, or —CH(phenyl)- wherein the phenyl is optionally substituted with 1, 2, 3, 4, or 5 groups that are halogen or OH;
• R65 is cyclohexyl;
• cyclopentyl;
• phenyl;
• —(C1-C6 alkyl)-phenyl;
• NH2;
• mono or di(C1-C10 alkyl)amino wherein the alkyl group or groups are optionally substituted with 1 or 2 groups that are independently cyclopropyl, phenyl or OH;
• oxadiazolyl;
• triazolopyrimidinyl;
• triazolyl;
• thiadiazolyl;
• 3H-quinazolin-2-onyl;
• pyrimidinyl;
• pyridyl;
• pyridyl N-oxide;
• —(C1-C6 alkyl)-pyridyl;
• piperazinyl;
• phthalazinyl;
• tetrahydro-thiophenyl 1,1-dioxide;
• tetrazolyl;
• C3-C6 cycloalkyl-C1-C6 alkyl;
• —(C1-C4 alkyl)-SO2—(C1-C4 alkyl)-;
• benzothiazole;
• hexahydro-isoindole-1,3-dionyl;
• benzimidazolyl;
• benzoxazolyl;
• [1,2,4]triazolo[1,5-a]pyrimidinyl;
• thiazolyl;
• thiadiazolyl;
• imidazo[1,2-a]pyridine;
• C1-C6 alkyl;
• 3-aza-bicyclo[3.2.2]nonane;
• pyrrolidinonyl;
• diazepanyl;
• benzo[1,2,5]thiadiazolyl;
• —NHSO2-(4-methylphenyl);
• [1,2,4]triazolo[4,3-b]pyridazinyl, benzopyrrolidinonyl;
• morpholinyl;
• thiomorpholinyl;
• thiomorpholinyl S-oxide;
• thiomorpholinyl S,S-dioxide;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• pyrrolidinyl;
• [1,2,4]oxadiazole;
• C1-C10 alkyl;
• isoxazolyl;
• 2,3-dihydro-1H-indolyl;
• quinazolinonyl, quinazolinyl, piperidyl, C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, or C2-C6 alkynyl;
• wherein each of the above is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C6 alkyl, CF3, halogen, phenyl, —(C1-C4 alkyl)-phenyl, —C(O)phenyl, pyrrolidine-dione, C1-C6 alkoxy, —C(O)-furan, —C(O)NH2, —C(O)NH(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)(C1-C6 alkyl),cyclopropyl, —(CH2)0-4-cyclopentyl, benzoxazolyl, pyridine, —NHC(O)—(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl), —C(O)C1-C6 alkyl, —CO2H, —NHSO2—(C1-C8 alkyl), —N(C1-C6 alkyl)SO2—(C1-C8 alkyl), —CO2—(C1-C6 alkyl).

A compound of the formula wherein

• 1594
• or a pharmaceutically acceptable salt thereof, wherein
• X10 is —O—, —S—, —NH—, —N(C1-C6 alkyl);
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl);
• R40 is phenyl, -phenyl-pyridine, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isooxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl, —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl) -phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl) (C1-C6 alkyl), CN, —(C1-C4 alkyl)-(C3-C7 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl, —(C1-C4 alkyl)-R33, C1-C8 alkyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —C(O)NH2, wherein each of the above rings is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, halo (C1-C4 alkyl), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, —CHO, —NHSO2—(C1-C4 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl is optionally substituted with 1, 2, or 3 halogens,
• R42 is H, C1-C6 alkyl, benzyl, —NHC(O)—(C1-C6 alkyl), or —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• R52 is H, phenyl, —NHC(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), OH, C1-C6 alkyl, mono or di(C1-C6 alkyl)amino, —NHC(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with a phenyl, —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl) wherein the alkyl groups are each optionally substituted with a phenyl, —(CH2)0-4—SO2—(C1-C10 alkyl), —NHCO2-benzyl, or —NH2, and
• R60 is -L-V-R65, C1-C8 alkyl, or hydroxy C1-C8 alkyl, wherein the alkyl or hydroxyalkyl groups are optionally substituted with 1 or 2 L-V-R65 groups, wherein
• L is absent, —C(O)—, —CO2—, —C(O)NH—, —C(O)N(C1-C6 alkyl)-, —NHC(O)—, —N(C1-C6 alkyl)-C(O)—, —(CH2)0-4—SO2—(CH2)0-4—, —(CH2)0-4—O—(CH2)0-4—, —(CH2)0-4—S—(CH2)0-4—, —NHC(O)NH—, —N(C1-C6 alkyl)C(O)NH—, —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)-, —NHC(O)N(C1-C6 alkyl)-, —NH—, —N(benzyl)-, —N(phenyl)-, —(CH2)0-4—NHSO2—(CH2)0-4—, —N(C1-C6 alkyl)SO2—, —SO2NH—, —SO2N(C1-C6 alkyl)-, or
• V is absent, —(CH2)0-4—C(O)NH—, —(CH2)0-4—C(O)N(C1-C6 alkyl)-, cyclopropyl optionally substituted with 1 or 2 C1-C4 alkyl groups, ═NH, ═NOH, ═N-alkoxy, C3-C8 alkyl optionally substituted with 1 or 2 OH, or —CH(phenyl)- wherein the phenyl is optionally substituted with 1, 2, 3, 4, or 5 groups that are halogen or OH;
• R65 is cyclohexyl;
• cyclopentyl;
• phenyl;
• —(C1-C6 alkyl)-phenyl;
• NH2;
• mono or di(C1-C10 alkyl)amino wherein the alkyl group or groups are optionally substituted with 1 or 2 groups that are independently cyclopropyl, phenyl or OH;
• oxadiazolyl;
• triazolopyrimidinyl;
• triazolyl;
• thiadiazolyl;
• 3H-quinazolin-2-onyl;
• pyrimidinyl;
• pyridyl;
• pyridyl N-oxide;
• —(C1-C6 alkyl)-pyridyl;
• piperazinyl;
• phthalazinyl;
• tetrahydro-thiophenyl 1,1-dioxide;
• tetrazolyl;
• C3-C6 cycloalkyl-C1-C6 alkyl;
• —(C1-C4 alkyl)-SO2-(C1-C4 alkyl)-;
• benzothiazole;
• hexahydro-isoindole-1,3-dionyl;
• benzimidazolyl;
• benzoxazolyl;
• [1,2,4]triazolo[1,5-a]pyrimidinyl;
• thiazolyl;
• thiadiazolyl;
• imidazo[1,2-a]pyridine;
• C1-C6 alkyl;
• 3-aza-bicyclo[3.2.2]nonane;
• pyrrolidinonyl;
• diazepanyl;
• benzo[1,2,5]thiadiazolyl;
• —NHSO2-(4-methylphenyl);
• [1,2,4]triazolo[4,3-b]pyridazinyl, benzopyrrolidinonyl;
• morpholinyl;
• thiomorpholinyl;
• thiomorpholinyl S-oxide;
• thiomorpholinyl S,S-dioxide;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• pyrrolidinyl;
• [1,2,4]oxadiazole;
• C1-C10 alkyl;
• isoxazolyl;
• 2,3-dihydro-1H-indolyl;
• quinazolinonyl, quinazolinyl, piperidyl, wherein each of the above is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently
• C1-C6 alkyl, CF3, halogen, phenyl, —(C1-C4 alkyl)-phenyl, —C(O)phenyl, pyrrolidine-dione, C1-C6 alkoxy, —C(O)-furan, —C(O)NH2, —C(O)NH(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)(C1-C6 alkyl),cyclopropyl, —(CH2)0-4-cyclopentyl, benzoxazolyl, pyridine, —NHC(O)—(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl), —C(O)C1-C6 alkyl, —CO2H, —NHSO2—(C1-C8 alkyl), —N(C1-C6 alkyl)SO2—(C1-C8 alkyl).

A compound of the formula

• 1595
• or a pharmaceutically acceptable salt thereof, wherein
• R30 is selected from the group consisting of phenyl, pyrazolopyrimidinyl, oxa-aza-benzoazulenyl, isoxazolyl, triazolopyridinyl, pyrrolidinonyl, tetrahydrothia-aza-fluorenyl, pyridyl, piperidinyl, dihydrocyclopentaquinolinyl, furyl, naphthothienyl, phthalazinonyl, thiadiazolyl, thienopyrimidinonyl, oxa-diaza-cyclopentanaphthalenyl, dihydrobenzodioxepinyl, chromanonyl, chromenonyl, oxazolidinyl, benzophenone, pyrazinyl mono N-oxide, benzofuranyl, pyrazolyl, -isoxazolyl-phenyl, phenyl-triazolyl, benzimidazolyl, indolyl, phenyl-pyrrolyl, chromanyl, isoquinolinyl, -thienyl-thienyl, benzothienyl, -phenyl-thiadiazolyl, chromanonyl, quinolinyl, -pyrrolyl-C(O)-phenyl, -phenyl-O-phenyl, -phenyl-oxazolyl, -pyrrolidinonyl-phenyl, -phenyl-pyrimidinyl, -phenyl-oxadiazolyl, bicyclo[2.2.1]heptenyl, cyclopentyl, thieno[2,3-b]thiophene, cyclohexyl, -phenyl-imidazolyl, benzoxazole;
• dihydro-1H-indolyl;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• benzo[b] thiophene 1,1-dioxide;
• 2,3-dihydro-benzo[d]isothiazole 1,1-dioxide;
• -phenyl-thiazolyl;
• -phenyl-pyrazolyl, -phenyl-C(O)-piperidyl, -phenyl-C(O)-pyrrolidinyl, -phenyl-isoxazolyl, isoindolyl, purinyl, oxaxolyl, thiazolyl, pyridazinonyl, thiazolyl, pyranyl, dihydropyranopyridinyl, diazepanyl, cyclopropyl, dihydronaphthoisoxazolyl, benzoindazole, dihydrocyclopentachromenonyl, imidazopyrazolyl, tetrahydrocyclopentachromenonyl, dihydroquinolinonyl, pyridyl N-oxide, isochromanyl, quinazolinonyl, pyrazolopyridinyl, dihydrobenzothiophene dioxide, dihydrofurobenzoisoxazolyl, dihydropyrimidine dionyl, thienopyrazolyl, oxazolyl, tetrahydrocyclopentapyrazolyl, dihydronaphthalenonyl, dihydrobenzofuranonyl, dihydrocyclopentathienyl, tetrahydrocyclopentapyrazolyl, tetrahydropyrazoloazepinyl, indazolyl, tetrahydrocycloheptaisoxazolyl, tetrahydroindolonyl, pyrrolidinyl, thienopyridinyl, dioxodihydrobenzoisothiazolonyl, triazolopyrimidinyl, thienyl, dihydrothienopyrimidinonyl, and benzooxadiazolyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of
• C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN;
• OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl;
• haloalkyl, haloalkoxy, (CH2)0-4C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33;
• —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33;
• —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl) (C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33;
• —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —O—(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N(C1-C6 alkyl) (C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)thienyl, —(C1-C6 alkyl) furanyl, —S—(C1-C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl) (C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br;
• pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8 cycloalkyl, —O—(C1-C6 alkyl)-R33;
• pyrrole optionally substituted with one or two methyl groups;
• 2,3-dihydro-benzofuran;
• benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl)(C1-C6 alkyl);
• —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, S—(C1-C6 alkyl), indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, —CO2—(C1-C6 alkyl), C1-C10 alkanoyl;
• —(CH2)0-4—SO2—(C1-C10alkyl) wherein the alkyl group is optionally substituted with OH;
• wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms;
• —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl, wherein
• the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or
• R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl;
• R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl) (phenyl), N(C1-C6 alkyl) (benzyl);
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl), or (CH2)0-4CN;
• R40 is phenyl, -phenyl-pyridyl, biphenyl, -phenyl-benzothienyl, -phenyl-thienyl, -phenyl-furanyl, -phenyl-pyrimidinyl, -phenyl-isoxazolyl, —C(O)-pyridyl, —(C1-C4 alkyl)-O—C(O)NH-phenyl wherein the phenyl is optionally substituted with 1, 2, or 3 halogen atoms;
• —(C1-C4 alkyl)-O—C(O)N(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-phenyl, —(C1-C4 alkyl)-SO2NH2, —(C1-C4 alkyl)-SO2NH(C1-C6 alkyl), —(C1-C4 alkyl)-SO2N(C1-C6 alkyl)(C1-C6 alkyl), —SO2NH2, —SO2NH(C1-C6 alkyl), —SO2N(C1-C6 alkyl)(C1-C6 alkyl), CN, —(CH2)0-4—(C3-C8 cycloalkyl), —(C1-C4 alkyl)-C(O)O—(C1-C4 alkyl), —(C1-C4 alkyl)-R33, C1-C10 alkyl, C2-C8 alkenyl, —(C1-C4 alkyl)-NHC(O)—(C1-C4 alkyl), —(CH2)0-4—C(O)NH2, —(CH2)0-4—C(O)NH(C1-C6 alkyl), —(CH2)0-4—C(O)N(C1-C6 alkyl)(C1-C6 alkyl), naphthyl, tetrahydronapthyl, dihydronaphthyl, —(CH2)0-4-imidazolyl, —(CH2)0-4-pyrrolidinyl, oxazolidinone 3,4-dihydro-benzo[e][1,2]oxathiine 2,2-dioxide, pyrimidinyl, 3,4-dihydro-2H-benzo[e][1,2]thiazine 1,1-dioxide, pyridyl, or pyrimidyl, alkoxyalkyl, -phenyl-benzothienyl, -phenyl-cyclohexyl, -phenyl-cyclopentyl, -phenyl-(C1-C6 alkyl)-cyclopentyl, -phenyl-(C1-C6 alkyl)-cyclohexyl, -phenyl-oxazolyl, furanyl, tetrahydrofuranyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C8 alkyl optionally substituted with 1 or two groups that are independently CN or OH;
• C1-C6 alkoxy, halo (C1-C8 alkyl), halo (C1-C4 alkoxy), —O—(C1-C4 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 halogens, CN, —CHO, C1-C4 thioalkoxy, —NHSO2—(C1-C6 alkyl), —N(C1-C4 alkyl)SO2—(C1-C4 alkyl) wherein the alkyl groups are optionally substituted with 1, 2, or 3 halogens;
• OH;
• —SO2R33;
• R33;
• C2-C8 alkynyl;
• C2-C8 alkenyl;
• thioalkoxyalkyl;
• —SO2—(C1-C10 alkyl);
• —NR31R32;
• —C(O)—NR31R32;
• —OC(O)R33;
• C1-C8 alkanoyl;
• —(C1-C6 alkyl)-C(O)—(C1-C6 alkoxy);
• R41a and R41 are independently H, cyclohexyl, phenyl, or C1-C6 alkyl optionally substituted with 1 or 2 groups that are phenyl, hydroxy, C1-C4 thioalkoxy, C1-C4 thioalkoxy C1-C6 alkyl;
• or —C1-C6 alkyl-SO2—C1-C6 alkyl;
• R40, R41, and the atom to which they are attached form a C3-C8 cycloalkyl ring which is optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen, —CO2NH2, —CO2NH(C1-C6 alkyl), —CO2N(C1-C6 alkyl) (C1-C6 alkyl), thiazolyl optionally substituted with C1-C6 alkyl, isoxazolyl optionally substituted with C1-C6 alkyl, or phenyl which is optionally substituted with 1, 2, or 3 groups that are independently halogen or C1-C6 alkyl;
• and
• R42 is H, C1-C6 alkyl optionally substituted with OH;
• benzyl;
• —NHC(O)—(C1-C6 alkyl);
• —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups.

A compound of the formula

• 1596
• or a pharmaceutically acceptable salt thereof, wherein
• R30 is selected from the group consisting of phenyl, pyrazolopyrimidinyl, oxa-aza-benzoazulenyl, isoxazolyl, triazolopyridinyl, pyrrolidinonyl, tetrahydrothia-aza-fluorenyl, pyridyl, piperidinyl, dihydrocyclopentaquinolinyl, furyl, naphthothienyl, phthalazinonyl, thiadiazolyl, thienopyrimidinonyl, oxa-diaza-cyclopentanaphthalenyl, dihydrobenzodioxepinyl, chromanonyl, chromenonyl, oxazolidinyl, benzophenone, pyrazinyl mono N-oxide, benzofuranyl, pyrazolyl, -isoxazolyl-phenyl, phenyl-triazolyl, benzimidazolyl, indolyl, phenyl-pyrrolyl, chromanyl, isoquinolinyl, -thienyl-thienyl, benzothienyl, -phenyl-thiadiazolyl, chromanonyl, quinolinyl, -pyrrolyl-C(O)-phenyl, -phenyl-O-phenyl, -phenyl-oxazolyl, -pyrrolidinonyl-phenyl, -phenyl-pyrimidinyl, -phenyl-oxadiazolyl, bicyclo[2.2.1]heptenyl, cyclopentyl, thieno[2,3-b]thiophene, cyclohexyl, -phenyl-imidazolyl, benzoxazole;
• dihydro-1H-indolyl;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• benzo[b]thiophene 1,1-dioxide;
• 2,3-dihydro-benzo[d]isothiazole 1,1-dioxide;
• -phenyl-thiazolyl;
• -phenyl-pyrazolyl, -phenyl-C(O)-piperidyl, -phenyl-C(O)-pyrrolidinyl, -phenyl-isoxazolyl, isoindolyl, purinyl, oxaxolyl, thiazolyl, pyridazinonyl, thiazolyl, pyranyl, dihydropyranopyridinyl, diazepanyl, cyclopropyl, dihydronaphthoisoxazolyl, benzoindazole, dihydrocyclopentachromenonyl, imidazopyrazolyl, tetrahydrocyclopentachromenonyl, dihydroquinolinonyl, pyridyl N-oxide, isochromanyl, quinazolinonyl, pyrazolopyridinyl, dihydrobenzothiophene dioxide, dihydrofurobenzoisoxazolyl, dihydropyrimidine dionyl, thienopyrazolyl, oxazolyl, tetrahydrocyclopentapyrazolyl, dihydronaphthalenonyl, dihydrobenzofuranonyl, dihydrocyclopentathienyl, tetrahydrocyclopentapyrazolyl, tetrahydropyrazoloazepinyl, indazolyl, tetrahydrocycloheptaisoxazolyl, tetrahydroindolonyl, pyrrolidinyl, thienopyridinyl, dioxodihydrobenzoisothiazolonyl, triazolopyrimidinyl, thienyl, dihydrothienopyrimidinonyl, and benzooxadiazolyl, wherein each of the above is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently selected from the group consisting of
• C1-C10 alkyl optionally substituted with 1 phenyl or 1 CN;
• OH, hydroxy C1-C10 alkyl optionally substituted with phenyl or (C1-C4 alkyl)phenyl, C1-C6 alkoxy optionally substituted with 1 or 2 groups that are independently hydroxy or phenyl;
• haloalkyl, haloalkoxy, (CH2)0-4—C(O)NR31R32, —NR31—SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1, 2, or 3 groups that are independently halogen or R33, —SO2—NH(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, alkoxy, or R33;
• —(C1-C6 alkyl)-SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH, C1-C4 alkoxy, or R33;
• —SO2—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with 1 or 2 groups that are independently OH or C1-C4 alkoxy, —SO2—N(C1-C6 alkyl) (C1-C6 alkyl) wherein each alkyl group is optionally substituted with 1 or 2 groups that are independently halogen, OH or R33;
• —SO2—NH(C1-C6 alkyl)-phenyl wherein the phenyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkoxy or halogen, —O—(C1-C6 alkyl)-phenyl, —(C1-C6 alkyl)-O-phenyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl)-phenyl, triazolidine-3,5-dione, halogen, —NHC(O)NH2, —NHC(O)NH(C1-C6 alkyl), —NHC(O)N(C1-C6 alkyl) (C1-C6 alkyl), —N(C1-C6 alkyl)C(O)NH2, —N(C1-C6 alkyl)C(O)NH(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)(C1-C6 alkyl), —(C1-C6 alkyl) thienyl, —(C1-C6 alkyl) furanyl, —S—(C1-C6 alkyl) phenyl, —SO2NR31R32, —C(O)—NR31R32, —NR31R32, dithiane, —NHC(S)NH2, —NHC(S)NH(C1-C6 alkyl), —NHC(S)N(C1-C6 alkyl) (C1-C6 alkyl), —CO2(C1-C6 alkyl), tetrahydropyran, phenyl optionally substituted with 1 or 2 groups that are independently F, Cl or Br;
• pyridine, —C2-C4 alkynyl-phenyl, —O—C3-C8cycloalkyl, —O—(C1-C6 alkyl)-R33;
• pyrrole optionally substituted with one or two methyl groups;
• 2,3-dihydro-benzofuran;
• benzo[1,2,5]oxadiazole, —C(O)—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with NH2, N(C1-C6 alkyl), or N(C1-C6 alkyl) (C1-C6 alkyl);
• —C(O)NH-phenyl, —C(O)N(C1-C6 alkyl)-phenyl, 4,4-dimethyl-4,5-dihydro-oxazole, —(C1-C6 alkyl)-S-pyridine, —(C1-C6 alkyl)-SO2-pyridine, —(C1-C6 thioalkoxy)-pyridine, thiazole optionally substituted with 1 or 2 methyl groups, pyrazole, S—(C1-C6 alkyl), indole, (C1-C6 thioalkoxy)-(C1-C6 alkyl), C2-C8 alkynyl, —CO2—(C1-C6 alkyl), C1-C10 alkanoyl;
• —(CH2)0-4—SO2—(C1-C10 alkyl) wherein the alkyl group is optionally substituted with OH;
• wherein R31 and R32 at each occurrence are independently selected from the group consisting of hydrogen, C1-C8 alkyl, C2-C8 alkenyl, hydroxy C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C6 alkyl, —(CH2)0-4—SO2—(C1-C6 alkyl) wherein the alkyl is optionally substituted with 1, 2, 3 or 4 independently selected halogen atoms;
• —(CH2)0-4—SO2-imidazolyl, —(C1-C6 alkyl)-C(O)NH2, —(C1-C6 alkyl)-C(O)NH(C1-C6 alkyl), —(C1-C6 alkyl)-C(O)N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)-NH2, —(C1-C6 alkyl)-NH(C1-C6 alkyl), —(C1-C6 alkyl)-N(C1-C6 alkyl) (C1-C6 alkyl), —(C1-C6 alkyl)phenyl, —(C1-C6 alkyl)pyridyl, —C(O)furanyl, (C1-C6 alkyl)-tetrahydrofuran, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, —CO2—(C1-C6 alkyl), —(C1-C6 alkyl)-furanyl, —(CH2)0-4—SO2-thienyl , wherein
• the phenyl and pyridyl groups are unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, hydroxy, C1-C4 alkoxy, halogen, or
• R31, R32 and the nitrogen to which they are attached form a 5, 6, or 7 membered heterocycloalkyl or a 6 membered heteroaryl ring, each of which is optionally fused to a benzene, pyridine or pyrimidine ring and each of which is optionally substituted with C1-C6 alkoxy, hydroxy, hydroxy C1-C6 alkyl, C1-C4 alkoxy C1-C6 alkyl, —C(O)NH2, —C(O)NH—(C1-C6 alkyl)-phenyl;
• R33 at each occurrence is independently, H, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl) (C1-C6 alkyl), N(C1-C6 alkyl) (phenyl), N(C1-C6 alkyl) (benzyl);
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl), or (CH2)0-4CN;
• R42 is H, C1-C6 alkyl optionally substituted with OH;
• benzyl;
• —NHC(O)—(C1-C6 alkyl);
• —NHC(O) -phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• and
• R48 is —C(O)R49,
• wherein R49 is phenyl, or C1-C8 alkyl, each of which is optionally substituted with halogen, C1-C4 alkoxy, C1-C4 alkyl, or R33.

A compound of the formula

• 1597
• or a pharmaceutically acceptable salt thereof, wherein
• R35 is phenyl, C3-C8 cycloalkyl, —S-phenyl, benzodioxole, thienyl, C1-C6 alkyl, furanyl, imidazolyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), —(C1-C4 alkyl)-(C5-C6 cycloalkyl), or (CH2)0-4CN;
• R42 is H, C1-C6 alkyl optionally substituted with OH;
• benzyl;
• —NHC(O)—(C1-C6 alkyl);
• —NHC(O)-phenyl wherein the phenyl is optionally substituted with 1 or 2 alkyl groups;
• and
• R48 is —C(O)R49,
• wherein R49 is phenyl, or C1-C8 alkyl, each of which is optionally substituted with halogen, C1-C4 alkoxy, C1-C4 alkyl, or R33;
• R52 is H, phenyl, —NHC(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl)-(C1-C6 thioalkoxy), OH, C1-C6 alkyl, mono or di(C1-C6 alkyl)amino, —NHC(O)—(C1-C6 alkyl) wherein the alkyl group is optionally substituted with a phenyl, —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl) wherein the alkyl groups are each optionally substituted with a phenyl, —(CH2)0-4—SO2—(C1-C10 alkyl), —NHCO2-benzyl, or —NH2, and
• R60 is -L-V-R65, C1-C8 alkyl, or hydroxy C1-C8 alkyl, wherein the alkyl or hydroxyalkyl groups are optionally substituted with 1 or 2 L-V-R65 groups, wherein
• L is absent, —C(O)—, —CO2—, —C(O)NH—, —C(O)N(C1-C6 alkyl)-, —NHC(O)—, —N(C1-C6 alkyl)-C(O)—, —(CH2)0-4—SO2—(CH2)0-4—, (CH2)0-4—O—(CH2)0-4—, —(CH2)0-4—S—(CH2)0-4—, —NHC(O)NH—N(C1-C6 alkyl)C(O)NH—, —N(C1-C6 alkyl)C(O)N(C1-C6 alkyl)-, —NHC(O)N(C1-C6 alkyl)-, —NH—, —N(benzyl)-, —N(phenyl)-, —(CH2)0-4—NHSO2—(CH2)0-4—, —N(C1-C6 alkyl)SO2—, —SO2NH—, —SO2N(C1-C6 alkyl)-, or
• V is absent, —(CH2)0-4—C(O)NH—, —(CH2)0-4—C(O)N(C1-C6 alkyl)-, cyclopropyl optionally substituted with 1 or 2 C1-C4 alkyl groups, ═NH, ═NOH, ═N-alkoxy, C1-C8 alkyl optionally substituted with 1 or 2 OH, or —CH(phenyl)- wherein the phenyl is optionally substituted with 1, 2, 3, 4, or 5 groups that are halogen or OH;
• R65 is cyclohexyl;
• cyclopentyl;
• phenyl;
• —(C1-C6 alkyl)-phenyl;
• NH2;
• mono or di(C1-C10 alkyl)amino wherein the alkyl group or groups are optionally substituted with 1 or 2 groups that are independently cyclopropyl, phenyl or OH;
• oxadiazolyl;
• triazolopyrimidinyl;
• triazolyl;
• thiadiazolyl;
• 3H-quinazolin-2-onyl;
• pyrimidinyl;
• pyridyl;
• pyridyl N-oxide;
• —(C1-C6 alkyl)-pyridyl;
• piperazinyl;
• phthalazinyl;
• tetrahydro-thiophenyl 1,1-dioxide;
• tetrazolyl;
• C3-C6 cycloalkyl-C1-C6 alkyl;
• —(C1-C4 alkyl)-SO2—(C1-C4 alkyl);
• —SO2—(C1-C6 alkyl);
• benzothiazole;
• hexahydro-isoindole-1,3-dionyl;
• benzimidazolyl;
• benzoxazolyl;
• [1,2,4]triazolo[1,5-a]pyrimidinyl;
• [1,2,4]triazolo[4,3-a]pyrimidinyl, thiazolyl;
• thiadiazolyl;
• imidazo[1,2-a]pyridine;
• C1-C6 alkyl;
• 3-aza-bicyclo[3.2.2]nonane;
• pyrrolidinonyl;
• diazepanyl;
• benzo[1,2,5]thiadiazolyl;
• —NHSO2-(4-methylphenyl);
• [1,2,4]triazolo[4,3-b]pyridazinyl, benzopyrrolidinonyl;
• morpholinyl;
• thiomorpholinyl;
• thiomorpholinyl S-oxide;
• thiomorpholinyl S,S-dioxide;
• 2,3-dihydro-benzo[b]thiophene 1,1-dioxide;
• pyrrolidinyl;
• [1,2,4]oxadiazole;
• C1-C10 alkyl;
• isoxazolyl;
• 2,3-dihydro-1H-indolyl;
• quinazolinonyl, quinazolinyl, piperidyl, wherein each of the above is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently
• C1-C6 alkyl, CF3, halogen, phenyl, —(C1-C4 alkyl)-phenyl, —C(O)phenyl, pyrrolidine-dione, C1-C6 alkoxy, —C(O)-furan, —C(O)NH2, —C(O)NH(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)(C1-C6 alkyl), cyclopropyl, —(CH2)0-4-cyclopentyl, benzoxazolyl, pyridine, —NHC(O)—(C1-C6 alkyl), —N(C1-C6 alkyl)C(O)—(C1-C6 alkyl), —C(O)C1-C6 alkyl, —CO2H, —NHSO2—(C1-C8 alkyl), —N(C1-C6 alkyl)SO2—(C1-C8 alkyl)

A compound of the formula

• 1598
• or a pharmaceutically acceptable salt thereof, wherein
• n, p, and q are independently 0, 1 or 2;
• a dashed line represents a single or double bond;
• R1, R2, R3, and R4 are independently selected from
• hydrogen, halogen, C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halo(C1-C6) alkyl, hydroxy(C1-C6) alkyl, halo(C1-C6)alkoxy, thio(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, amino(C1-C6)alkyl, mono(C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6) alkylamino (C1-C6) alkyl,
• —(CH2)0-4-aryl or —(CH2)0-4-heteroaryl,
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono (C1-C6)alkylamino, and di(C1-C6) alkylamino,
• —(CH2)0-4—C3-C7 cycloalkyl, where the cycloalkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6) alkylamino;
• Rz, Rz′, Rz″, and Rz′″ independently represent
• C1-C6 alkyl, optionally substituted with one, two or three substituents independently selected from C1-C3 alkyl, halogen, —OH, —SH, —C≡N, —CF3, C1-C6 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6)alkylamino,
• hydroxy, nitro, halogen, —CO2H, cyano,
• —(CH2)0-4—CO—NR142R144 where R142 and R144 independently represent hydrogen, C1-C6 alkyl, hydroxyl (C1-C6)alkyl, amino(C1-C6)alkyl, haloalkyl, C3-C7 cycloalkyl, —(C1-C2 alkyl)-(C3-C7 cycloalkyl), —(C1-C6 alkyl)-O—(C1-C3 alkyl), —C2-C6 alkenyl with one or two double bonds, —C2-C6 alkynyl with one or two triple bonds, —C1-C6 alkyl chain with one double bond and one triple bond, —R1-aryl where R1-aryl is as defined above, or R1-heteroaryl where R1-heteroaryl,
• —(CH2)0-4—CO—(C1-C12 alkyl), —(CH2)0-4—CO—(C2-C12 alkenyl), CH2)0-4—CO—(C2-C12) alkynyl, —(CH2)0-4—CO—(C3-C7 cycloalkyl), —(CH2)0-4—CO—R1-aryl where R1-aryl is as defined above, —(CH2)0-4—CO—R1-heteroaryl where R1-heteroaryl is as defined above, —(CH2)0-4—CO—R1-heterocycle, —(CH2)0-4—CO—R146 where R146 is heterocycloalkyl, where the heterocycloalkyl is optionally substituted with 1-4 of C1-C6 alkyl,
• —(CH2)0-4—CO—O—R148where R148 is selected from the group consisting of:
• C1-C6 alkyl, —(CH2)0-2—(R1-aryl), C2-C6 alkenyl, C2-C6 alkynyl, C3C7 cycloalkyl, and —(CH2)0-2—(R1-heteroaryl),
• —(CH2)0-4—SO2—N R142R144, —(CH2)0-4—SO—(C1-C8 alkyl), —(CH2)0-4—SO2 (C1-C12 alkyl), —(CH2)0-4—SO2—(C3-C7 cycloalkyl), —(CH2)0-4—N(H or R148)—CO—O—R148, —(CH2)0-4—N(H or R148)—CO—N(R148)2, —(CH2)0-4—N—CS—N(R148)2, —(CH2)0-4—N(—H or R148) —CO—R142, —(CH2)0-4—NR142R144, —(CH2)0-4—R146 where RN-4 is as defined above,
• —(CH2)0-4—O—CO—(C1-C6 alkyl), —(CH2)0-4—O—P(O)—(OR150)2 where each R150 is independently hydrogen or C1-C4 alkyl, —(CH2)0-4—O—CO—N(R148)2, —(CH2)0-4—O—CS—N(R148)2—(CH2)0-4—O—(R148)2, —(CH2)0-4—O—(R148)2—CO2H, —(CH2)0-4—S—(R148)2, —(CH2)0-4—O-halo (C1-C6) alkyl, —(CH2)0-4—O—(C1-C6) alkyl, C3-C7 cycloalkyl,
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with C1-C3 alkyl, halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6)alkylamino,
• —(CH2)0-4—N(—H or R148)—SO2—R142, or —(CH2)0-4—C3-C7 cycloalkyl;
• R35 is phenyl, cyclohexyl, —S-phenyl, benzodioxole, thienyl, C3-C6 alkyl, furanyl, each of which is unsubstituted or substituted with 1, 2, 3, 4, or 5 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, OH, hydroxy C1-C6 alkyl, halogen, halo C1-C6 alkyl, halo C1-C6 alkoxy, —O—(C1-C6 alkyl)-phenyl, —CO2—(C1-C6 alkyl), or —(C1-C4 alkyl)-(C5-C6 cycloalkyl);
• X and Y are independently selected from O, NR5, C(O), CR1R2, SO2, and S,
• where R5 is hydrogen, C1-C6 alkyl, SO2R5′, C(O)R5′ where R5′ is hydrogen, halogen, C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halo(C1-C6) alkyl, halo(C1-C6)alkoxy, thio(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, amino(C1-C6)alkyl, mono(C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6) alkylamino (C1-C6) alkyl,
• —(CH2)0-4-aryl or —(CH2)0-4-heteroaryl,
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono (C1-C6)alkylamino, and di(C1-C6)alkylamino,
• —(CH2)0-4—C3-C7 cycloalkyl, where the cycloalkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6) alkylamino;
• R140 represents phenyl or naphthyl, each of which is optionally substituted with 1-5 groups independently selected from C1-C6 alkyl, optionally substituted with one, two or three substituents selected from the group consisting of
• C1-C3 alkyl, -halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6)alkylamino,
• hydroxy, nitro, halogen, —CO2H, cyano,
• —(CH2)0-4—CO—NR142R144 where R142 and R144 independently represent hydrogen, C1-C6 alkyl, hydroxyl (C1-C6)alkyl, amino(C1-C6)alkyl, haloalkyl, C3-C7 cycloalkyl, —(C1-C2 alkyl)-(C3-C7 cycloalkyl), —(C1-C6 alkyl)-O—(C1-C3 alkyl), —C2-C6 alkenyl with one or two double bonds, —C2-C6 alkynyl with one or two triple bonds, —C1-C6 alkyl chain with one double bond and one triple bond, —R1-aryl or —R1-heteroaryl,
• —(CH2)0-4—CO—(C1-C12 alkyl), —(CH2)0-4—CO—(C2-C12 alkenyl), CH2)0-4—CO—(C2-C12)alkynyl, —(CH2)0-4—CO—(C3-C7 cycloalkyl), —(CH2)0-4—CO—R1-aryl where R1-aryl is as defined above, —(CH2)0-4—CO—R1-heteroaryl where R1-heteroaryl is as defined above, —(CH2)0-4CO—R1heterocycle, —(CH2)0-4—CO—R146 where R146 is heterocycloalkyl, where the heterocycloalkyl is optionally substituted with 1-4 of C1-C6 alkyl,
• —(CH2)0-4—CO—O—R148where R148 is selected from the group consisting of:
• C1-C6 alkyl, —(CH2)0-2—(R1-aryl), C2-C6 alkenyl, C2-C6 alkynyl, C3C7 cycloalkyl, and —(CH2)0-2—(R1-heteroaryl),
• —(CH2)0-4—SO2—N R142R144, —(CH2)0-4—SO—(C1-C8 alkyl), —(CH2)0-4-SO2 (C1-C12 alkyl), —(CH2)0-4—SO2—(C3-C7 cycloalkyl), —(CH2)0-4—N(H or R148)—CO—O—R148, —(CH2)0-4—N(H or R148)—CO—N(R148)2, —(CH2)0-4—N—CS—N(R148)2, —(CH2)0-4—N (—H or R148) —CO—R142, —(CH2)0-4—NR142R144, —(CH2)0-4—R146 where RN-4 is as defined above,
• —(CH2)0-4—O—CO—(C1-C6 alkyl), —(CH2)0-4—O—P(O)—(OR150)2 where each R150 is independently hydrogen or C1-C4 alkyl, —(CH2)0-4—O—CO—N(R148)2, —(CH2)0-4—O—CS—N(R148)2—(CH2)0-4—O—(R148)2, —(CH2)0-4—O—(R148)2—CO2H, —(CH2)0-4—S—(R148)2, —(CH2)0-4—O-halo(C1-C6)alkyl, —(CH2)0-4—O—(C1-C6) alkyl, C3-C7 cycloalkyl,
• C2-C6 alkenyl or C2-C6 alkynyl, each of which is optionally substituted with C1-C3 alkyl, halogen, hydroxy, —SH, cyano, —CF3, C1-C3 alkoxy, amino, mono(C1-C6)alkylamino, and di(C1-C6)alkylamino, and
• —(CH2)0-4—N(—H or R148)—SO2—R142, or —(CH2)0-4—C3-C7 cycloalkyl.

A compound of the formula:

• 1603
• wherein
• R100 is H, C1-C8 alkoxycarbonyl, phenyl C1-C6 alkyl, or phenyl C1-C6 alkoxycarbonyl;
• R110 is phenyl C1-C6 alkyl, thienyl, —S-phenyl, furanyl, or benzodioxolyl, wherein each is optionally substituted with 1, 2, 3, 4, or 5 groups that are independently halogen, C1-C4 alkyl, C1-C4 alkoxy, or phenyl C1-C6 alkoxy;
• and
• R120 is H, phenyl C1-C6 alkyl, C3-C8 cycloalkyl optionally substituted with C1-C6 alky or phenyl, C3-C8 cycloalkyl C1-C4 alkyl, or C1-C6 alkyl optionally substituted with —C(O)NR121R122, wherein each of the above is optionally substituted with 1, 2, or 3 groups that are independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, or C1-C6 alkoxy;
• wherein
• R121 and R122 are independently H, or C1-C6 alkyl.

A compound of the formula

• 1604
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C1-C4 alkyl, C2-C4 alkynyl, or CF3;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 and the carbon to which they are attached form a cyclopropyl ring;
• R4 is oxazolyl optionally substituted with methyl, thiazolyl, C2-C4 alkynyl, or C1-C4 alkyl;
• R5 is C1-C4 alkyl;
• R6 is C1-C4 alkyl;
• X and Y are independently halogen;
• Z is CH or N.

A compound of the formula

• 1607
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are independently halogen;
• R5 is C1-C2 alkyl sulfonyl;
• R6 is hydroxyethyl or methoxyethyl.

A compound of the formula

• 1608
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl;
• or
• R5 is H and R6 is C3 alkyl;
• or
• R5, R6, and the nitrogen to which they are attached form a pyrrolidinyl ring optionally substituted with methoxymethyl;
• and
• Rs is C1-C2 alkyl, hydroxy(C2-C4)alkyl, N-[hydroxy(C2-C4) alkyl]-N-(C1-C2)alkylamino, N-methyl-N—(C4 (t-butyl)alkyl)amino, —NH(C1-C4 hydroxyalkyl), —N(C1-C3 hydroxyalkyl) (C1-C3 hydroxyalkyl), —N(C1-C2 alkyl) (C1-C2 alkyl), pyrrolidin-1-yl optionally substituted with hydroxymethyl or methoxymethyl, C1-C2 alkoxy C2-C3 alkyl, 1-piperazinyl, —NH2, —NH(C2-C3 alkyl-NH(C1-C2 alkyl)), or C1-C4 (C2) alkylamino.

A compound of the formula

• 1609
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are independently halogen;
• R5 and R6 are independently C1-C4 alkyl;
• and
• Rd is C1-C2 alkyl, N-hydroxy(C2-C3)alkyl-N-(C1-C2)alkylamino, or C1-C2 alkylamino.

A compound of the formula

• 1610
• or a pharmaceutically acceptable salt thereof, wherein
• X is nitrogen or CH;
• R1 is C2-C3 alkyl, amino, mono(C1-C3)alkylamino, di(C1-C3) alkylamino, amino(C1-C3)alkyl, mono(C1-C3)alkylamino(C1-C2) alkyl, or di(C1-C3) alkylamino(C1-C2) alkyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are both hydrogen or independently halogen;
• R5 and R6 are independently methyl or C2-C3-C4 alkyl, where at least one of R5 and R6 is not methyl.

A compound of the formula

• 1611
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl;
• and
• Rj is hydrogen or C1-C2 alkoxymethyl.

A compound of the formula

• 1612
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C4 alkynyl, C2-C4 alkyl, or trifluoromethyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl;
• or
• one of R5 and R6 is methyl or ethyl and the other is C3C4 alkyl.

A compound of the formula

• 1613
• or a pharmaceutically acceptable salt thereof, wherein
• one of X or X1 is nitrogen or N+—O− while the other is CH;
• R1 is C2-C4 alkynyl, cyano, or C1-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• Rp is hydrogen, C1-C2 alkyl, or oxazolyl;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1614
• or a pharmaceutically acceptable salt thereof, wherein
• Rc is a group of the formula
• 1615
• where one of X and X′ is nitrogen and the other is CH and R1 is C2-C4 alkyl or —(C1-C2 alkyl)-N(C1-C2 alkyl) (C1-C2 alkyl);
• Rf and Rg are independently halogen;
• Rp is C1-C2 alkyl;
• and
• R5 and R6 are independently hydrogen or C3-C4 (sec butyl) alkyl.

A compound of the formula

• 1616
• or a pharmaceutically acceptable salt thereof, wherein
• Rs is methylamino, ethylamino, C3 alkylamino, di(C3-alkyl)amino, or a group of the formula
• 1617
• where Rq is C1-C2 alkoxy(C1-C2)alkyl;
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• and
• Rf and Rg are independently halogen.

A compound of the formula

• 1618
• or a pharmaceutically acceptable salt thereof, wherein
• Z is CH when the dashed line represents a single bond or a carbon atom or nitrogen atom when the dashed line represents a double bond;
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rp is hydrogen, cyano, C1-C3 alkyl, amino, N-(C1-C3 alkylsulfonyl)-N-((C1-C3)alkyl)amino, 2-oxazolyl, or 1-pyrrolyl optionally substituted in the 2 and 5 positions with C1-C2 alkyl;
• and
• Rj is C1-C5 alkyl.

A compound of the formula

• 1619
• or a pharmaceutically acceptable salt thereof, wherein
• both of X and X′ are CH, or one of X and X′ is nitrogen and the other is CH;
• R1 is C2-C3 alkynyl, C1,2-C3 alkyl, amino, mono(C1-C3)alkylamino, or di(C1-C3) alkylamino, aminoalkyl, mono(C1-C3) alkylamino(C1-C2)alkyl, di(C1-C3)alkylamino(C1-C2)alkyl, CF3, C1-C2 alkoxy, halogen, —NHSO2 (C1-C2 alkyl);
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are both hydrogen or independently halogen;
• R5 and R6 are independently C1-C4 alkyl;
• or
• one of R5 and R6 is methyl or ethyl and the other is C3 or C4 alkyl.

A compound of the formula

• 1620
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rs is C3-C4 alkyl, thiazolinyl or thiazolidinyl.

A compound of the formula

• 1621
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl, CF3, or —NH(C3-C6 cycloalkyl);
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together with the carbon atom to which they are attached form a 3-membered ring;
• Rp is pyridyl, piperazinyl, amino, amino(C1-C5)alkyl, mono(C1-C2)alkylamino(C1-C5)alkyl, di(C1-C2)alkylamino(C1-C5)alkyl, mono(C1-C3)alkylamino, di(C1-C3)alkylamino, amino(C3-C4)alkynyl, mono(C1-C2)alkylamino(C3-C4)alkynyl, di(C1-C2)alkylamino(C3-C5)alkynyl, —N(C1-C2 alkyl)-SO2(C1-C2 alkyl), —NH—SO2(C1-C2 alkyl), —N(C1-C2 alkyl)-SO2-thienyl, —N(C1-C2 alkyl)-SO2(C1-C2 haloalkyl), di(C1-C2)alkylamino(C3-C4)alkynyl, pyrimidinyl, pyrazolyl, imidazolyl, or C2-C4 alkynyl;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1622
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkynyl;
• R2 and R3 are both hydrogen;
• Rp is C1-C3 alkyl;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl;
• or
• one of R5 and R6 is methyl and the other is C3 or C4 alkyl.

A compound of the formula

• 1623
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C1-C2 alkyl, C2-C4 alkynyl or C3-C4 alkyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• Rp is C1-C3 alkyl or a group of the formula:
• RsSO2— where Rs is
• R51R61N— and R51 and R61 independently represent hydrogen or C1-C4 alkyl groups;
• or
• a group of the formula:
• 1624
• where Rt is C1-C2 alkoxy(C1-C2)alkyl;
• and
• Rq is C1-C3 alkoxy(C1-C2)alkyl, C1-C4 alkyl, —C(O)NH2, or H.

A compound of the formula

• 1626
• or a pharmaceutically acceptable salt thereof, wherein
• Z is oxygen, nitrogen, or sulfur;
• R1 is chloro, bromo, hydrogen or C1-C2 alkyl;
• Rf and Rg are independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl;
• or
• one of R5 and R6 is methyl and the other is C3 or C4 alkyl.

A compound of the formula

• 1627
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C1-C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• Rp is C1-C2 alkyl;
• Rf and Rg are both hydrogen or independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1628
• or a pharmaceutically acceptable salt thereof, wherein
• one of X and X′ is nitrogen and the other is CH or CR1;
• R1 is C1-C2-C3 alkyl
• R2 and R3 are both hydrogen;
• Rp is C1-C2 alkyl;
• Rf and Rg are independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1629
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is a group of the formula:
• 1630
• where
• one of Rs11 and R′s11 is hydrogen and the other is C1-C3 acyl, C1-C2 alkyl or CHO;
• or
• one of Rs11 and R′s11 is methyl and the other is CHO or methyl,
• each Rs21 is C1-C3 alkoxy, halogen, H, C1-C2 alkyl or cyano;
• or
• R1 is cyclopentyl, cyclohexyl, oxazolyl, isoxazolyl optionally substituted with one or two C1-C2 alkyl groups, phenyl, thien-2-yl optionally substituted with CHO, unsubstituted thien-3-yl;
• R2 and R3 are both hydrogen;
• Rp is C1-C2 alkyl;
• Rf and Rg are independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1631
• or a pharmaceutically acceptable salt thereof, wherein
• Z is
• 1632
• R1 is C1-C3 alkyl or halogen;
• R2 and R3 are both hydrogen;
• Rs is C1-C3 alkylsulfonyl, C1-C3 alkylsulfonyl(C1-C3)alkyl, —NHSO2(C1-C2 alkyl), or —N(C1-C2 alkyl)SO2(C1-C2 alkyl);
• and
• Rf and Rg are independently halogen.

A compound of the formula

• 1634
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• R5 and R6 independently represent (a) C1-C3 alkyl optionally substituted with phenyl and (b) phenyl optionally substituted with halogen;
• and
• Rf and Rg are independently halogen.

A compound of the formula

• 1635
• or a pharmaceutically acceptable salt thereof, wherein
• X is nitrogen or N+—O−;
• R1 is C2-C4 alkynyl or C1-C3 alkyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• Rp is hydrogen or C1-C2 alkyl;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1636
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is hydrogen or C1-C3 alkyl;
• R2 and R3 are both hydrogen;
• Rp is C1-C2 alkyl;
• Rf and Rg are independently halogen;
• and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula

• 1637
• or a pharmaceutically acceptable salt thereof, wherein
• Rs is NR13,R141 where
• RS31 is C1-C2 alkyl;
• and
• RS41 is C1-C6 alkyl, allyl, cyano(C1-C3)alkyl, (C4-C7)cycloalkyl, pyridyl (C1-C3)alkyl, phenyl, phenyl (C1-C3),alkyl, amino(C1-C3)alkyl, mono(C1-C3)alkylamino(C1-C2)alkyl, or di(C1-C3)alkylamino(C1-C2)alkyl;
• or
• Rs is CH3, —N(C1-C2 alkyl)phenyl, or —N(C2-C3 alkyl) (C3-C4 alkyl);
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• and
• Rf and Rg are independently halogen.

A compound of the formula

• 1638
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkynyl or C1-C3 alkyl;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C1-C4 alkyl.

A compound of the formula

• 1639
• or a pharmaceutically acceptable salt thereof, wherein
• Rs is C1-C4 alkyl;
• Rm is C1-C4 alkyl;
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• and
• Rf and Rg are independently halogen.

A compound of the formula

• 1640
• or a pharmaceutically acceptable salt thereof, wherein
• Rm is C1-C4 alkyl;
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• and
• Rf and Rg are independently halogen;
• Z is S, S(O), S(O)2, or O.

A compound of the formula

• 1641
• or a pharmaceutically acceptable salt thereof, wherein
• one of X and X′ is CH and the other is N;
• R1 is C2-C4 alkynyl;
• amino(C1-C3)alkyl, mono(C1-C3)alkylamino(C1-C2)alkyl, or di(C1-C3)alkylamino(C1-C2)alkyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C1-C3-C4 alkyl.

A compound of the formula

• 1642
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rp is hydrogen, cyano, C1-C3 alkyl, amino, N-(C1-C3 alkylsulfonyl)-N-((C1-C3)alkyl)amino, 2-oxazolyl, or 1-pyrrolyl optionally substituted in the 2 and 5 positions with C1-C2 alkyl;
• Ra is C1-C3 alkyl, H or trifluoromethyl;
• and
• Rj is C1-C5 alkyl.

A compound of the formula

• 1643
• or a pharmaceutically acceptable salt thereof, wherein
• X is nitrogen or N+—O−;
• R1 is C2-C4 alkynyl, cyano, C1-C3 alkyl, or CF3;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together form a 3-membered ring with the carbon atom to which they are attached;
• Rf and Rg are independently halogen;
• Rp is hydrogen, cyano or C1-C2 alkyl;
• and
• R5 and R6 are independently C1-C4 alkyl.

A compound of the formula

• 1644
• or a pharmaceutically acceptable salt thereof, wherein
• R1 is hydrogen or methyl;
• R2 and R3 are both hydrogen;
• or
• R2 and R3 together with the carbon atom to which they are attached form a 3-membered ring;
• Rp is C2-C3 alkynyl or C1-C3 alkyl;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl, or
• R5 is methyl and R6 is C3-C4 alkyl.

A compound of the formula:

• 1645
• wherein
• R1 is C2-C3 alkyl;
• R2 and R3 are both methyl or
• R2, R3, and the carbon to which they are attached form a cyclopropyl ring;
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl;
• and
• Rs is —NH(C1-C4 hydroxyalkyl).

A compound of the formula:

• 1646
• wherein
• R1 is C2-C3 alkynyl;
• R2 and R3 are both hydrogen;
• or
• Rf and Rg are independently halogen;
• R5 and R6 are independently C3-C4 alkyl;
• and
• Rs is —NH(C2-C4 hydroxyalkyl).

A compound of the formula:

• 1647
• wherein,
• Rc is C4-C5 alkyl;
• cyclopropyl;
• tetrahydronaphthylenyl;
• —CH(C2 alkyl-S—(C1-C2) alkyl)C(O)NH(C4 alkyl);
• —CH(C2 alkyl-SO2—(C1-C2) alkyl)C(O)NH(C4 alkyl);
• pyrimidyl optionally substituted with C3-C4 alkyl;
• thiochroman 1,1-dioxide;
• —CH2-thiazolyl optionally substituted with C3-C4 alkyl;
• Rf and Rg are independently halogen;
• Rp is —NHSO2CF3, —SO2NH(C3-C4 hydroxyalkyl), —NHSO2CH3;
• oxazol-2-yl, and
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula:

• 1648
• wherein
• R1 is C2-C3 alkyl, or halogen;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• and
• Rm is —NH—SO2CF3, oxazol-2-yl, —N(CH3)SO2CH3, —N(C3-C4 hydroxyalkyl)SO2(C1-C2 alkyl), and Rp is H;
• or
• Rm is H and Rp is —NH—SO2CF3, —CH2SO2(C1-C2 alkyl);
• or
• Rm is —C(O)pyrrolidinyl and Rp is OH.

A compound of the formula:

• 1649
• wherein
• R1 is C2-C5 alkyl, C3-C6 cyanoalkyl, C3-C6 alkenyl, —NHSO2(C1-C2 alkyl), C4-C5 haloalkyl, —C3 alkyl-CO2—(C1-C2 alkyl), CN, —N(C1-C2 alkyl)SO2(C1-C2 alkyl), —SO2(C1-C2 alkyl), —NH—(C3-C6 cycloalkyl), —OC(O)N(C1-C2 alkyl) (C1-C2 alkyl),
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rp is C1-C2 alkyl;
• R5 and R6 are independently C3-C5 alkyl, C1-C2 alkoxy C1-C2,3 alkyl, or
• R5 is H and R6 is C4,5-C6 alkyl or (C1-C2 alkoxy)-(C2-C3 alkyl);
• R5 is ethyl and R6 is C2-C3 hydroxyalkyl or —(C1-C2 alkyl)-N(C1-C2 alkyl) (C1-C2 alkyl);
• or
• R5 is CH3 and R6 is C4-C5 alkyl, cyclohexyl, —(C1-C2 alkyl)-phenyl, —(C1-C2 alkyl)-pyridyl, or —CH2-furyl;
• or
• R5 is methyl or ethyl and R6 is (C1-C2 alkoxy)-(C2-C3 alkyl), or
• R5, R6, and the nitrogen to which they are attached form a piperidinyl ring optionally substituted with C3-C4 alkyl or OH, azepanyl, pyrrolidine-2-carboxylic acid amide, 3-hydroxypiperidin-1-yl.

A compound of the formula:

• 1650
• wherein
• R1 is C2-C3 alkyl, halogen, —NH(cyclopropyl),
• Rf and Rg are independently halogen;
• Rp is C1-C2 alkyl, oxazolyl, thiazolyl, or C2-C3 alkynyl;
• R2, R3, and the carbon to which they are attached form a cyclopropyl ring;
• or
• R2 and R3 are both methyl;
• R5 and R6 are independently C3-C4 alkyl;
• or
• R5 is methyl and R6 is C3-C5 alkyl.

A compound of the formula:

• 1651
• wherein
• Rc is isoxazolyl optionally substituted with C3-C5 alkyl, thiazolyl optionally substituted with C3-C4 alkyl, or —C1-C3 alkyl-C(O)NH(C1-C3 alkyl);
• Rf and Rg are independently halogen;
• Rp is C1-C2 alkyl, oxazolyl, thiazolyl, or C2-C4 alkynyl;
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula:

• 1652
• wherein
• Hal is a halogen;
• R1 is C1-C2 alkyl, or halogen;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rz is C1-C2 alkyl;
• R5 and R6 are independently C3-C4 alkyl.

A compound of the formula:

• 1653
• n is 0 or 1;
• R1 is C1-C2 alkyl;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rs is (C1-C2)alkoxy(C1-C2)alkyl.

A compound of the formula:

• 1654
• wherein
• R1 is C1-C2 alkyl;
• R2 and R3 are both hydrogen;
• Rf and Rg are independently halogen;
• Rp is isoxazole optionally substituted with C1-C2 alkyl;
• R5 and R6 are independently C3-C4 alkyl.

A compound which is

• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-isobutylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-N3-propyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N3-methyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalamide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-oxazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(1-ethylcarbamoylethylamino)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropylisophthalamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N′-dimethylcarbamoylmethyl-5,N′-dimethylisophthalamide;
• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(1-methylcarbamoyl-3-methylsulfanyl-propylamino)-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• N-[3-(1-Benzylcarbamoyl-ethylamino)-1-(3,5-difluorobenzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropylisophthalamide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-4-trifluoromethyl-benzamide;
• 3,4-Dichloro-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;
• N-[3-(1-Carbamoyl-3-methyl-butylamino)-1-(3,5-difluorobenzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropylisophthalamide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-4-methoxy-benzamide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-2,6-difluoro-benzamide;
• N-[3-(1-Carbamoyl-ethylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-2,6-dimethoxy-benzamide;
• 2-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methylsulfanyl}-N-(4-oxazol-5-yl-phenyl)-acetamide;
• 2-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methylsulfanyl}-N-(5-methyl-isoxazol-3-yl)-acetamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-methanesulfonyl-benzenesulfonamide;
• 2-Cyano-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;
• 2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-4-trifluoromethoxy-benzenesulfonamide;
• 2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-6-methyl-benzenesulfonamide;
• 5-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-2-methoxy-benzenesulfonamide;
• 2-Chloro-4-cyano-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-trifluoromethyl-benzenesulfonamide;
• 4-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-benzoic acid;
• 6-Chloro-pyridine-3-sulfonic acid [1-(3,5-difluorobenzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzenesulfonamide;
• Pyridine-3-sulfonic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-(2-Chloro-4-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propylsulfamoyl]-phenyl}-acetamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-trifluoromethoxy-benzenesulfonamide;
• N-{5-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-thiophen-2-ylmethyl}-benzamide;
• 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-{5-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylsulfamoyl]-4-methyl-thiazol-2-yl}-acetamide;
• 4-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;
• 3-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethylbenzylamino)-2-hydroxy-propyl]-benzenesulfonamide;
• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxybenzylamino)-propyl]-2-trifluoromethyl-benzenesulfonamide;
• 6-Chloro-pyridine-3-sulfonic acid [1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• Pyridine-3-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-2-methanesulfonyl-benzenesulfonamide;
• 3,5-Dichloro-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;
• 1,2-Dimethyl-1H-imidazole-4-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-3,4-dimethoxy-benzenesulfonamide;
• 2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• 3-{4-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylsulfamoyl]-phenyl}-propionic acid methyl ester;
• 3-Chloro-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;
• 3-Cyano-N-[1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-benzenesulfonamide;
• Butane-1-sulfonic acid [1-(3,5-difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propyl]-amide;
• N-{1-(3,5-Difluoro-benzyl)-2-hydroxy-3-[(1-methanesulfonyl-piperidin-4-ylmethyl)-amino]-propyl}-5-methyl-N′,N′-dipropyl-isophthalamide;
• N-[3-Benzenesulfonylamino-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• N-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzoylamino)-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• 4-(3,5-Difluoro-phenyl)-3-(2,5-dimethyl-4-nitro-2H-pyrazol-3-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(2-Amino-7H-purin-6-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(4-Chloro-pyrimidin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(2-Amino-6-methyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(2-Chloro-6-methyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(2-Amino-6-chloro-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(1-phenyl-1H-tetrazol-5-ylamino)-butan-2-ol;
• 3-(2-Chloro-7H-purin-6-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-ylamino]-butan-2-ol;
• 3-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-pyrazine-2-carbonitrile;
• 4-(3,5-Difluoro-phenyl)-3-(4,6-dimethoxy-[1,3,5]triazin-2-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 2-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinonitrile;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(7H-purin-6-ylamino)-butan-2-ol;
• 3-(Benzothiazol-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(2-phenyl-quinolin-4-ylamino)-butan-2-ol;
• 6-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinonitrile;
• 2-[1-(3,5-Difluoro-benzyl)-2-hydroxy-3-(3-methoxy-benzylamino)-propylamino]-nicotinic acid ethyl ester;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(3-methyl-5-nitro-3H-imidazol-4-ylamino)-butan-2-ol;
• 3-(Benzooxazol-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(quinolin-4-ylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-3-(5-ethyl-pyrimidin-2-ylamino)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(4-trifluoromethyl-pyrimidin-2-ylamino)-butan-2-ol;
• 3-(6-Chloro-2-methylsulfanyl-5-phenyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(3-Chloro-quinoxalin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(8-trifluoromethyl-quinolin-4-ylamino)-butan-2-ol;
• 3-(6-Chloro-2,5-diphenyl-pyrimidin-4-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 3-(3-Chloro-pyrazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(5-trifluoromethyl-pyridin-2-ylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(quinolin-2-ylamino)-butan-2-ol;
• 3-(6-Chloro-pyrazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(3-nitro-pyridin-2-ylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(pyrimidin-2-ylamino)-butan-2-ol;
• 4-(3,5-Difluoro-phenyl)-1-(3-methoxy-benzylamino)-3-(2-phenyl-quinazolin-4-ylamino)-butan-2-ol;
• N-[3-(N′-Acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;
• 3-(4,6-Diamino-[1,3,5]triazin-2-ylamino)-4-(3,5-difluoro-phenyl)-1-(3-methoxy-benzylamino)-butan-2-ol;
• 5-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-hydroxy-benzamide;
• 2-(2,5-Dimethyl-pyrrol-1-yl)-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-{1-(3,5-Difluoro-benzyl)-2-hydroxy-3-[3-(3-hydroxymethyl-piperidine-1-carbonyl)-phenylamino]-propyl}-5-methyl-N′,N′-dipropyl-isophthalamide;
• 4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[3-(3-Cyclohexyl-1-phenyl-propylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-5-methyl-N′,N′-dipropyl-isophthalamide;
• 2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2,6-dimethyl-phenoxy)-propionamide;
• 2-Methanesulfonylamino-oxazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-amide;
• 4-Acetylamino-1-methyl-1H-pyrrole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Ethyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;
• 2-Methanesulfonylamino-oxazole-4-carboxylic acid [3-(N′-benzoyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;
• 6-Methyl-4-oxo-1-phenyl-1,4-dihydro-pyridazine-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Methanesulfonylamino-thiazole-4-carboxylic acid {1-benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-amide;
• 4-Methyl-2-phenyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Methanesulfonylamino-thiazole-4-carboxylic acid [3-(N′-acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-pyridin-3-yl-benzamide;
• 2-p-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-{1-Benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl)-hydrazino]-2-hydroxy-propyl}-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;
• 2-Phenoxymethyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-{1-Benzyl-3-[N-ethyl-N′-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;
• [1,2,5]Thiadiazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[3-(N′-Acetyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;
• 2-m-Tolyl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[3-(N′-Benzoyl-N-ethyl-hydrazino)-1-benzyl-2-hydroxy-propyl]-2-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-acetamide;
• 2-(2-Chloro-phenyl)-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-{1-Benzyl-3-[N-ethyl-N′-(3-ethyl-benzoyl) -hydrazino]-2-hydroxy-propyl}-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-phenyl-2-tetrazol-1-yl-propionamide;
• N-[1-Benzyl-3-[N-ethyl-N′-(4-methyl-pentanoyl)-hydrazino]-2-hydroxy-propyl}-3-hydroxy-4-(pyrrolidine-1-carbonyl)-benzamide;
• 4-Chloro-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Propyl-tetrahydro-pyran-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 5-p-Tolyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Acetylamino-5-chloro-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N′-(2-fluoro-5-methanesulfonyl-phenyl)-succinamide;
• 1-(4-Fluoro-phenyl)-5-methyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-(2-Acetyl-thiophen-3-yl)-N′-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;
• 6-Chloro-4-trifluoromethyl-pyridine-2-carboxy;ic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-acetamide;
• N-(1-Cyclopropyl-ethyl)-N′-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-N-phenyl-succinamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(3,4-dimethoxy-phenylsulfanyl)-acetamide;
• 1-Methyl-5-oxo-2-pyridin-3-yl-pyrrolidine-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-Methoxy-thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2,5-Dimethyl-1-pyridin-4-ylmethyl-1H-pyrrole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Methyl-5-thiophen-2-yl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-(4-Benzyl-[1,4]diazepan-1-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-butyramide;
• 2-(Benzo[1,2,5]thiadiazol-4-yloxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;
• 3-Chloro-5-phenyl-isothiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-5-phenylethynyl-nicotinamide;
• 4,7-Dimethoxy-benzofuran-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-morpholin-4-ylmethyl-benzamide;
• 2,2-Dimethyl-4-oxo-chroman-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• [1,6]Naphthyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 8-Cyano-4-hydroxy-quinoline-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Pyridin-3-yl-thiazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 5-Chloro-benzofuran-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-Dibenzofuran-2-yl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-butyramide;
• N-{[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-nicotinamide;
• 4-tert-Butyl-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;
• 4-Chloro-N-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propylcarbamoyl]-methyl}-benzamide;
• 4-Chloro-6-methyl-quinoline-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2,4-dihydroxy-thiazol-5-yl)-acetamide;
• 2-Methyl-pyrimidine-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-piperidin-1-yl-benzamide;
• 4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-methoxy-benzamide;
• 4-Methyl-oxazole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 1H-Indole-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 6-Chloro-1H-indole-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-(4-Chloro-2-oxo-benzothiazol-3-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;
• Thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-Methyl-oxazole-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(1-oxy-pyridin-3-yl)-acetamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-hydroxy-2-phenyl-2-thiophen-2-yl-acetamide;
• 6-Hydroxy-2-methylsulfanyl-pyrimidine-4-carboxylic aci [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2,5-Dimethyl-furan-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-nicotinamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-(3-methoxy-phenyl)-4-oxo-butyramide;
• 4-Acetyl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-benzamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-hydroxy-3,5-dimethoxy-benzamide;
• Furan-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetamide;
• 4-Acetylamino-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2,6-dimethyl-benzamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-thiophen-2-yl-acetamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-oxo-4-phenyl-butyramide;
• 1H-Indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide;
• 3-Benzo[1,3]dioxol-5-yl-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-morpholin-4-yl-4-oxo-butyramide;
• [2,3′]Bithiophenyl-5-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 5-Methoxy-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-Phenyl-thiophene-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 2-(5-Benzo[1,3]dioxol-5-yl-tetrazol-2-yl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;
• 2-(Benzothiazol-2-ylmethoxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-acetamide;
• Pyrrolidine-1,2-dicarboxylic acid 1-{[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide}2-phenylamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(6-ethoxy-1H-benzoimidazol-2-yl)-propionamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-acetamide;
• 2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• Thieno[3,2-c]pyridine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 1-Methyl-1H-indole-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• Benzo[b]thiophene-3-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 4-Oxy-3-propyl-pyrazine-2-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• 1,1,3-Trioxo-2,3-dihydro-1H-116-benzo[d]isothiazole-6-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(7-hydroxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanyl)-acetamide;
• 2-Hydroxy-6-methyl-quinoline-4-carboxylic acid [1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-amide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(2-methyl-2,3-dihydro-benzofuran-5-yl)-propionamide;
• 3-(Benzooxazol-2-ylsulfanyl)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-2-(5-o-tolyl-tetrazol-2-yl)-acetamide;
• 2-Chloro-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-4-tetrazol-1-yl-benzamide;
• N-(4-tert-Butyl-thiazol-2-yl)-N′-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;
• N-(5-Cyclopropyl-[1,3,4]thiadiazol-2-yl)-N′-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-succinamide;
• 2-(3-Chloro-phenoxy)-N-[1-(3,5-difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-propionamide;
• N-[1-(3,5-Difluoro-benzyl)-3-(3-ethyl-benzylamino)-2-hydroxy-propyl]-3-(pyridin-4-ylmethylsulfanyl)-benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• methyl [3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]methylcarbamate;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4S)-2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N2,N2-dipropylcyclopropane-1,2-dicarboxamide
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-pyrimidin-2-ylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-propylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3-isobutylisoxazol-5-yl)methyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formylthien-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• 5-bromo-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isobutylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N1-propylisophthalamide;
• N1,N1-dibutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-hydroxyprop-1-ynyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-thien-3-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(trifluoromethyl)benzyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperazin-1-ylsulfonyl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-sec-butylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(3-methylisoxazol-4-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N1-(cyclopropylmethyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 5-(aminosulfonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(1H-pyrazol-4-yl)isophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-5-methyl-N3-propylisophthalamide;
• N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-4-methylthien-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopentylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(1,1′-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1,N1-diallyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N3 N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3-propylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3, 5-dimethyl-N3-propylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(phenylsulfonyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diethyl-5-(1,3-oxazol-2-yl)isophthalamide;
• N2-[(benzylamino)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-3-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3-formyl-2-furyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1-methyl-1H-imidazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diethyl-5-methylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfinyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• 3-{[butyl(ethyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• N1-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutyl-N3,5-dimethylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-2-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3 N3-dipropylisophthalamide;
• N2-[(5-chlorothien-2-yl)sulfonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-[(1S,2R)-3-{[3-(5-acetylthien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-(sec-butyl)-N3-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-(2-phenylethyl)isophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3,5-dimethylisoxazol-4-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-prop-2-ynylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3,5-dimethylisophthalamide;
• 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl dimethylcarbamate;
• N1-benzyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
• N1-(sec-butyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N1-propylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl]amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;
• N1-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diisobutyl-5-methylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-(2-pyridin-2-ylethyl)isophthalamide;
• N1-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-hydroxy-3-(pyrrolidin-1-ylcarbonyl)benzamide;
• 5-oxo-D-prolyl-N1-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-4-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;
• methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoylamino)-2-hydroxybutyl]amino}methyl)phenylcarbamate;
• 5-oxo-L-prolyl-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutyl-5-methylisophthalamide;
• 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxo-3-{[(1-propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-isopropyl-5-methylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopropyl-N3, 5-dimethylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;
• N1-allyl-N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
• N-(3-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-3-oxo-2-{[(1-propylbutyl)sulfonyl]methyl}propyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(isopentylsulfonyl)propanamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopropyl-5-methylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 2-[3-(2-amino-2-oxoethoxy)phenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;
• N1-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-3-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2,4-dimethoxypyrimidin-5-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(4-hydroxypiperidin-1-yl)carbonyl]-5-methylbenzamide;
• N1-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 4′-[4-({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}amino)-4-oxobutanoyl]-1,1′-biphenyl-2-carboxamide;
• 1-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}-L-prolinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypiperidin-1-yl)carbonyl]-5-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[2-(dimethylamino)ethyl]-N3-ethyl-5-methylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide;
• 2-(5-acetylthien-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N3,N3-diisopropyl-5-methylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-2-[4-(2-oxopyrrolidin-1-yl)phenyl]acetamide;
• N-{(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}benzamide tri;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-ethyl-5-methylisophthalamide;
• 2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• N1-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-7-(1H-imidazol-1-yl)-5,6-dihydronaphthalene-2-carboxamide;
• 3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methylbenzamide;
• N1-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(ethylthio)ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[benzyl(cyanomethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[2-(2-hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzamide;
• methyl N-[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]-beta-alaninate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]butanamide;
• N1-[(1S,2R)-3-{[3-(1-benzothien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide;
• 2-{[(benzyloxy)carbonyl]amino}-7-[(cyclopropylmethyl)amino]-1,2,4,5,7-pentadeoxy-5-(3,5-difluorobenzyl)-1-[(1-propylbutyl)sulfonyl]-D-threo-hept-3-ulose trifluoroacetate;
• 1-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}-D-prolinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-pyrazol-1-yl)pentanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furylmethyl)-5-oxopyrrolidine-3-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-1-phenylethyl)amino]propyl}amino)sulfonyl]-N,N-dipropylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylpiperidine-1,3-dicarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-diethylpiperidine-1,3-dicarboxamide;
• 5-bromo-N1-(1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethoxypropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;
• N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3,3-dimethylbutyl)amino]-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,3-diphenylpropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)propyl]amino}propyl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S)-2-oxoazepan-3-yl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-cyclohexyl-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[(2-propylpentyl)sulfonyl]-beta-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-thiazol-2-yl)benzamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(phenyl)amino]propyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-1-(thien-2-ylmethyl)pyrrolidine-3-carboxamide;
• 4-[(butylthio)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)amino]sulfonyl}benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-oxazolidin-3-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-pyrrol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-[2-(trifluoromethyl)phenyl]succinamide;
• N1-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethyl-2-(1H-pyrrol-1-yl)thiophene-3-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3-dihydroxypropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2S)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-methylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• 2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxyethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-1-(3-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{methyl[(trifluoromethyl)sulfonyl]amino}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxamide;
• N1-[(1S,2R)-3-[(1,3-dicyclohexylpropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2′-bithiophene-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-imidazol-1-yl)butanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydroxy-N4-(4-methoxyphenyl)succinamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-{[2-(aminocarbonyl)-1H-indol-6-yl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide;
• 3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)thiophene-2-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1-ethylpropyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(methylthio)acetyl]-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,3-dimethylcyclohexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethoxy-1-benzothiophene-2-carboxamide;
• N1-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dioxo-1,2,4-triazolidin-4-yl)benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-[(3-methoxyphenyl)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(2-{4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-3-ylbutanamide;
• N1-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-[3-(trifluoromethyl)phenyl]butanamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• 2-(1H-1,2,3-benzotriazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}hexanamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(hydroxymethyl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;
• 5-(benzylthio)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrazole-5-carboxamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-2-carboxamide;
• N1-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4,7-dimethoxy-1-benzofuran-5-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-methylcyclohexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-2-ylbutanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxy-5-methylphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenoxybenzamide;
• 4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-(methylthio)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-hydroxy-4-oxochromane-2-carboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)propyl]amino}propyl)-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxamide;
• N1-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-pentylmalonamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(trifluoromethoxy)benzamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;
• N1-[4-(acetylamino)phenyl]-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• 3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-(5-phenyl-1,3,4-thiadiazol-2-yl)succinamide;
• N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,1-dioxidotetrahydrothien-2-yl)acetamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hex-1-ynylnicotinamide;
• N-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methoxyisoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dimethyl-1H-indole-7-carboxamide;
• 4-(3-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[5-(4-methylphenyl)-2H-tetraazol-2-yl]acetamide;
• N-{(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-3-phenylisoxazole-4-carboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(methylsulfonyl)acetyl]-N2-pentylglycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-indol-3-yl)-4-oxobutanamide;
• N1-(5-benzyl-1,3,4-thiadiazol-2-yl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-fluoro-4-methoxyphenyl)-4-oxobutanamide;
• ethyl 4-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}piperidine-1-carboxylate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-(2-fluorobenzoyl)-1H-pyrrole-2-carboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-morpholin-4-ylphenyl)acetamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)benzyl]propyl}propanamide;
• N1-benzyl-N1-(1-cyclopropylethyl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(2,5-dimethylbenzoyl)-5-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N4-(2-methoxy-5-methylphenyl)succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxyphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(ethylthio)nicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[4-(2-furoyl)piperazin-1-yl]-4-oxobutanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoisoindoline-1-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(ethylthio)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methyl-1,3-oxazol-2-yl)benzamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-N-methyl-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(3-methoxyphenyl)-4-oxobutanamide;
• N1-[(1S,2R)-3-(cycloheptylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-hydroxy-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;
• 6-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;
• 2-{[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methoxyphenyl)-4-oxobutanamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2,5-dioxopyrrolidin-1-yl)phenoxy]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-fluoro-2-hydroxyquinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-thien-2-ylbutanamide;
• N3-[({(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-N1,N1-dipropyl-beta-alaninamide;
• N1-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R,2S)-1-(hydroxymethyl)-2-methylbutyl]amino propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phenoxymethyl)benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N5-(2,4-difluorophenyl)pentanediamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N5-(4,6-dimethylpyrimidin-2-yl)pentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(3-methoxybenzoyl)-5-methylbenzamide;
• N1-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-oxobutanamide;
• methyl 4-{(2R,3R)-2-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-3-hydroxy-4-[(3-methoxybenzyl)amino]butyl}benzoate;
• N1-(4-acetylphenyl)-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;
• N1-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• 2-{[3-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-3-oxopropyl]thio}-N-methylbenzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)thio]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-(4-ethoxyphenyl)succinamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 3-methoxyphenylcarbamate;
• 3-(benzyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-([3-(trifluoromethyl)benzyl]aminoypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-hydroxyphenyl)-4-oxobutanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(piperidin-3-ylsulfonyl)benzamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-2-carboxamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(6-oxo-3-phenylpyridazin-1(6H)-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{4-[(methylsulfonyl)amino]phenyl}propanamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-(2-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propylipropanamide;
• N1-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-((1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methylphenyl)-4-oxobutanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-[3-(trifluoromethyl)phenyl]succinamide;
• N1-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-pyridin-2-yl-2H-tetraazol-2-yl)acetamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3,5-dimethoxyphenoxy)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dimethyl-1H-pyrrol-1-yl)-3-hydroxybenzamide;
• N1-{(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-[5-(cyclopentylmethyl)-1,3,4-thiadiazol-2-yl]-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N1-((1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-1,2-benzisothiazol-2(3H)-yl)acetamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[[-methyl-5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-naphthyl)-4-oxobutanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,6-diethoxypyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-pyrrol-2-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-({[2-(methylamino)ethyl]amino}sulfonyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(4-methylbenzoyl)benzamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(piperazin-1-ylsulfonyl)benzamide;
• N1-[(1S,2R)-3-({2-[4-(aminosulfonyl)phenyl]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-oxo-2,1-benzisothiazol-1(3H)-yl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,6-dihydroxypyrimidin-4-yl)acetamide;
• N1-{(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethyl)benzyl]propyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methyl-4-oxobutanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl)-N5-(2-pyridin-2-ylethyl)pentanediamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]acetamide;
• N2-(anilinocarbonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-oxo-2-(propylamino)ethyl]benzamide;
• N-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-(2-fluorophenyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylthiophene-2-carboxamide;
• 2-[4-(benzyloxy)phenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]acetamide;
• N1-(1-acetyl-2,3-dihydro-1H-indol-7-yl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N1-(3-acetylphenyl)-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pentanediamide;
• 3-(4-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxypropanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-7-carboxamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,2,3-thiadiazol-4-yl)benzamide;
• N-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[1-methyl-3-(methylthio)-1H-indol-2-yl]acetamide;
• N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-furyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)propanamide;
• 2-[2-(acetylamino)-1,3-thiazol-4-yl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]-2-phenylacetamide;
• N1-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 4-(1,3-benzothiazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;
• N1-(3-chloro-4-fluorophenyl)-N4-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-oxo-2,3-dihydroquinazolin-4-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-methyl-5-(2-methylbenzoyl)benzamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-propoxybenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-1H-indole-2-carboxamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methoxy-4-oxobutanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-thien-2-yl-1H-pyrazol-1-yl)acetamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5-phenylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-thioxo-1,3-benzothiazol-3(2H)-yl)acetamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N3 N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxy-4-methylphenyl)acetamide;
• N1-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-3-carboxamide;
• N′-(3,4-dichlorophenyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}malonamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-2-hydroxy-1-methylethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N5-pyridin-3-ylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-4-oxo-4H-chromene-6-carboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1H-imidazol-1-yl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]propanamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2,2-dimethylpropanoyl)amino]-2-hydroxybenzamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-[6-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-6-oxohexyl]-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-phenyl-4,5-dihydro-1H-tetraazol-5-yl)thio]acetamide;
• 4-acetyl-4-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclohexa-1,5-diene-1-sulfonamide;
• N-{(1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-chromen-6-yl)-4-oxobutanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide;
• N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N3 N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide 1-oxide;
• N-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• 2-(((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}amino)-2-oxoethyl carbamate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide;
• N-[5-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-5-oxopentyl]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide;
• 3-(1,3-benzothiazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methoxypropanamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(methylamino)carbonyl]amino}-3-thien-3-ylpropanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-pyridin-2-ylthiophene-2-carboxamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyridin-3-yl)acetamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide;
• 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)sulfonyl]benzoic acid;
• 5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(4-methoxyphenyl)acetyl]glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-4-carboxamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-hydroxy-3-methoxyphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3,5-dimethoxyphenyl)acetamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxo-2H-1,3-benzoxazin-3(4H)-yl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(pyrimidin-2-ylthio)acetamide;
• N1-[3-(aminocarbonyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-6-carboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-{[(methylamino)carbonothioyl]amino}benzamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}nicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-hydroxyphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phthalazin-1-ylthio)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-oxidopyridin-2-yl)thio]acetamide;
• 3-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-fluoro-1H-indole-2-carboxamide;
• N-((1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-3-methyl-4-oxobutanamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-(5-methyl-1,3,4-thiadiazol-2-yl)succinamide;
• N-{(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-1H-benzimidazol-1-yl)acetamide;
• N-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanamide;
• N-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-(6-methylpyridin-2-yl)succinamide;
• ethyl (4R)-4-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1,3-oxazolidine-3-carboxylate;
• N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-glycylbenzamide;
• N-{(1S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-methyl-1H-imidazol-2-yl)benzamide;
• 4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(pyrrolidin-3-ylsulfonyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)methyl]benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-3-methylbutyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[tert-butyl(cyclohexyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(2R)-1-ethylpyrrolidin-2-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)-2,2-dimethylpropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(diisopropylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1-ethylpyrrolidin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(1-benzylpyrrolidin-3-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrrolidin-1-ylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)propyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[2-(acetylamino)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[7-chloro-1-(2-hydroxy-3-methoxyphenyl)-3,4-dihydroisoquinolin-2(1H)-yl]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[4-(1-cyanocyclopentyl)phenyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-({4-[4-(acetylamino)phenoxy]phenyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3 dipropylisophthalamide;
• N1-[(1S,2R)-3-[(4-benzoyl-2,3-dimethylphenyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(2-amino-2-oxo-1-phenylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{4-[(1-methyl-1H-imidazol-2-yl)methyl]piperazin-1-yl}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-[3,5-bis(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• (1S,2R)-N1-[2-(tert-butylthio)ethyl]-N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclopropane-1,2-dicarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-benzo[g]indazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acetamide;
• 2-[2-(1,3-benzoxazol-2-yl)phenoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylbenzamide;
• 3-(3-chloroisoxazol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylypropanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(6-methoxy-1,1′-biphenyl-3-yl)-4-oxobutanamide;
• 4-(1-benzofuran-2-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamide;
• 2-(1-benzofuran-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylpropanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(1H-pyrrol-1-yl)phenyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2-b]pyrazole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-{[(4-methylphenyl)sulfonyl]amino}-4-oxohexanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;
• 7-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylquinoline-5-carboxamide;
• N3-(tert-butoxycarbonyl)-N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-b-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-propylhexanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-2-(1H-pyrrol-1-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetamide;
• 4-[2-(acetylamino)-4,5-dimethylphenyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide;
• 2-(1H,1′H-2,2′-biimidazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2,3-dihydro-1-benzofuran-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,2,4]triazolo[4,3-b]pyridazin-6-ylthio)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide;
• 2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-3,4-dihydroquinazoline-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(7-methoxy-1-benzofuran-2-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-ethyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)oxy]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyllpyrazine-2-carboxamide 4-oxide;
• 7-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-2-carboxamide;
• 2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3-(3,4-dimethoxyphenyl)-2-methylpropanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl]propanamide;
• 5-(4-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;
• 4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-pyrrol-1-yl)thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3,5-bis(methylthio)isothiazole-4-carboxamide;
• 2-chloro-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methoxyacetyl)amino]-3-phenylpropanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-fluoro-4-morpholin-4-ylbenzamide;
• N-{(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1-oxidothiomorpholin-4-yl)butanamide;
• 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;
• N-{2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-5-methyl-2-furamide;
• 1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxamide;
• N1-(2-chloropyridin-3-yl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• 3-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-methoxybenzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-pyrrolidin-1-yl-2H-tetraazol-2-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide;
• 1-(4-acetylphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}piperidine-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2-(1H-1,2,4-triazol-1-yl)propanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperidin-1-ylmethyl)-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1-benzothiophene-2-carboxamide 1,1-dioxide;
• 2-(2,1,3-benzoxadiazol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,2,3-thiadiazol-5-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furoyl)-4-hydroxyprolinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide;
• 4,5-dichloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isothiazole-3-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5-(1,3-thiazol-2-yl)pentanediamide;
• N-acetyl-4-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}phenylalaninamide;
• 8-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxycinnoline-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;
• 4-(1,3-benzodioxol-5-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(2-methylmorpholin-4-yl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{2-[hydroxy(phenyl)methyl]-4-methylpiperazin-1-yl}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-methylbutyl]aminopropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[4-(diethylamino)-1-methylbutyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxy-1,1-dimethylethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(2-methylpiperidin-1-yl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methyl-4,5,6,7-tetrahydro-3H-31ambda4-[1,3]thiazolo[5,4-c]pyridin-2-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-ethylbenzyl)amino]-2-hydroxy-1-(1H-pyrazol-1-ylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3,5-bis(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-[4-(aminosulfonyl)phenyl]-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;
• 1-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}piperidine-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methoxyphenoxy)propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-methylsuccinamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N4-(2,6-dimethylphenyl)succinamide;
• N-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-phenylalaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methylphenyl)sulfonyl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;
• 4-(cyclopentyloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-pyridin-3-ylsuccinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-phenylsuccinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-1,2,4-triazol-1-yl)pentanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{4-[(methylsulfonyl)amino]phenyl}-4-oxobutanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-pyridin-2-yl-1,3-thiazol-4-yl)acetamide;
• N1-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2,N2-dimethylphthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybutanamide;
• 2-(2H-1,2,3-benzotriazol-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide;
• 2-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide;
• N1-(2-cyanophenyl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzofuran-2-carboxamide;
• 1-benzyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethyl-1H-pyrazole-4-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(4-methylphenyl)sulfonyl]glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,1-dioxidotetrahydrothien-3-yl)acetamide;
• methyl 5-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1H-benzimidazol-2-ylcarbamate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methyl-1,3-benzoxazol-5-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-pyridin-4-yl-1,3-benzoxazol-5-yl)acetamide;
• 4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• 3-(aminosulfonyl)-4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• 2-(diethylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxypyrimidine-5-carboxamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4,N4-diphenylsuccinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide;
• 2-(1-benzothien-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[(4-methylphenyl)sulfonyl]-beta-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-hydroxyquinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-phenyl-1H-tetraazol-1-yl)acetamide;
• 4-{[(cyclobutylcarbonyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-benzoxazol-3(2H)-yl)butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxooctahydro-2H-isoindol-2-yl)butanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(tetrahydrofuran-2-ylmethyl)phthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1H-indol-1-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]thieno[3,2-b]pyridine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(6-methoxy-1H-benzimidazol-2-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylithieno[2,3-c]pyridine-2-carboxamide;
• 2-(1H-benzimidazol-2-ylthio)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,4-difluorobenzyl)oxy]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-tetraazol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylpyrimidine-4-carboxamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1-phenyl-1H-pyrazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)thio]acetamide;
• 2-(acetylamino)-N-{(1R,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-1,3-oxazole-4-carboxamide;
• N-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}acetamide;
• 1 2-{[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;
• 2-(3-azabicyclo[3.2.2]non-3-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;
• 2-(4-benzoylphenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-(7-methoxy-2,3-dihydro-1-benzofuran-4-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;
• N1-[(1S,2R)-1-[3-(cyclohexylmethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3 dipropylisophthalamide;
• 3-chloro-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;
• 3-chloro-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl benzamide;
• 3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;
• 3-chloro-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
• N-{(1S,2S)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-chlorobenzamide;
• N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-chlorobenzamide;
• 3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;
• 3-{[(3-chlorobenzyl)amino]sulfonyl}-N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
• 3-{[(3-chlorobenzyl)amino]sulfonyl}-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;
• 3-{[(3-chlorobenzyl)amino]sulfonyl}-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
• N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-chlorobenzyl)amino]sulfonyl}benzamide;
• N-{(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N-{(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(3-methoxybenzyl)amino]sulfonyl}benzamide;
• N′-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(4,5-dimethyl-2-furoyl)-5-methylbenzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-(isopentylsulfonyl)propanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-methoxyethyl)(propyl)amino]sulfonyl}propanamide;
• N1-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{((S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethylbut-3-ynyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}-N5,N5-dipropylpentanediamide;
• N1-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-N5,N5-dipropylpentanediamide;
• N1-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}-N5, N5-dipropylpentanediamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl) propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(1-naphthylmethyl) propyl 1-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N′-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(thien-2-ylmethyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-hydroxybenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-1-(4-hydroxybenzyl)-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N1-{(1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]but-3-ynyl}-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl) amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-{(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N1-((1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N5,N5-dipropylpentanediamide;
• N1-((1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[3-(trifluoromethoxy)benzyl]propyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N1-[(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]-3-methylbutyl}-N5,N5-dipropylpentanediamide;
• N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S)-1-[(11R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}-N5,N5-dipropylpentanediamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1R,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-[(phenylthio)methyl]propyl}propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N-{(1R,2R)-3-(benzylamino)-2-hydroxy-1-[(phenylthio)methyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1R,2R)-2-hydroxy-3-(isopentylamino)-1-[(phenylthio)methyl]propyl}propanamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}propanamide;
• N1-{(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl) amino]propyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-3-(benzylamino)-1-[4-(benzyloxy)benzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyli-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]propanamide;
• N-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N′-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(1-naphthylmethyl)propyl]-3-[(dipropylamino)sulfonylipropanamide;
• N-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl) amino]propyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(i-naphthylmethyl)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-1-(2-furylmethyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N′-[(1S,2R)-1-(4-chlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• N1-{(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-2-(4H-1,2,4-triazol-3-ylthio)acetamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(benzylamino)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• 1-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylprolinamide;
• N-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• 1655
• N-[(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-1-(4-fluorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(4-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(thien-2-ylmethyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(tri fluoromethyl) benzyl] propyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)propanamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethyl)benzyl]propyl}-N5,N5-dipropylpentanediamide;
• N-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]but-3-ynyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(3-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-((1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl)but-3-ynyl}propanamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(hydroxymethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4R)-3-(2-hydroxyethyl)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-2,2-dioxido-3-propyl-3,4-dihydro-1H-isothiochromen-4-yl]amino propyl)-5-methyl-N,N-dipropylisophthalamide;
• N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl)-3-methylbutyl)propanamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S,4S)-6-isopropyl-3-methyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4R)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N-{(1S)-1-[(1R)-2-(benzylamino)-1-hydroxyethyl]-3-methylbutyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• 3-[(dipropylamino)sulfonyl]-N-((1S)-1-[(1R)-1-hydroxy-2-(isopentylamino)ethyl]-3-methylbutyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-methoxypropyl)(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide;
• N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-6-carboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-bromobenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide;
• N1-[(1S,2R)-1-(3-bromobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• benzyl (3R)-4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-2,2,3-trimethyl-4-oxobutanoate;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-hydroxyethyl)(methylsulfonyl)amino]nicotinamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(phenylsulfonyl)butanamide;
• (3S)-tetrahydrofuran-3-yl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• N-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-methoxyethyl)(methylsulfonyl)amino]isonicotinamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-(phenylsulfonyl)-beta-alaninamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(2-methoxyethyl)(methylsulfonyl)amino]nicotinamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-[(4-methylphenyl)sulfonyl]-beta-alaninamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-hydroxypropyl)(methylsulfonyl)amino]isonicotinamide;
• N1-[(1S,2R)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-[(4-fluorophenyl)sulfonyl]-beta-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-hydroxyethyl)(methylsulfonyl)amino]isonicotinamide;
• N-{(1S,2R)-3-(benzylamino)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxypropyl)-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-isopropylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-[3-fluoro-5-(trifluoromethyl)benzyl]-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(2-hydroxyethyl)(methylsulfonyl)amino]nicotinamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(4-methylphenyl)sulfonyl]glycinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)(methylsulfonyl)amino]nicotinamide;
• N-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethoxy)benzyl]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(4-fluorophenyl)sulfonyl]glycinamide;
• N1-{(1S,2R)-2-hydroxy-3-(isopentylamino)-1-[3-(trifluoromethoxy)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methylbenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3-methoxypropyl)(methylsulfonyl)amino]isonicotinamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(4-methoxyphenyl)sulfonyl]glycinamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-4-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-methoxypropyl)(methylsulfonyl)amino]nicotinamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-chlorophenyl)sulfonyl]propanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-{(1S,2R)-2-hydroxy-1-(4-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-(methylsulfonyl)-1H-indole-5-carboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(4-fluoro-3-methylbenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]-N2-(benzylsulfonyl)glycinamide;
• N-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-5-carboxamide;
• N-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-fluorophenyl)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(4-fluoro-3-methylbenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methoxybenzyl)propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-(methylsulfonyl)indoline-4-carboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]-N3-[(4-chlorophenyl)sulfonyl]-beta-alaninamide;
• N1-{(1S,2R)-3-(benzylamino)-2-hydroxy-1-[3-(trifluoromethyl)benzyl]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-3-(benzylamino)-1-(4-chlorobenzyl)-2-hydroxypropyl]-3-[(dipropylamino)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)indoline-6-carboxamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-(benzylsulfonyl)-beta-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1H-indole-4-carboxamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-methoxyphenyl)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[1-methyl-1-(methylsulfonyl)ethyl]benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(4-methylphenyl)sulfonyl]propanamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-fluoro-4-methoxybenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[1-methyl-1-(methylsulfonyl)ethyl]benzamide;
• N1-{(1S,2R)-2-hydroxy-1-(3-methoxybenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-benzyl-N4-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2,2-dimethylsuccinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(ethylsulfonyl)benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(3-methoxybenzyl)propyl]-N5,N5-dipropylpentanediamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(propylsulfonyl)benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide;
• N1-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]-N5,N5-dipropylpentanediamide;
• (2R)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methyl-3-(phenylsulfonyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pentylsulfonyl)benzamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3-chloro-5-fluorobenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• (2S)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methyl-3-(phenylsulfonyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)sulfonyl]benzamide;
• N1-[(1S,2R)-1-(3-chloro-5-fluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-methoxyethyl)sulfonyl]benzamide;
• N1-{(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N1-benzyl-N5-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}pentanediamide;
• N-[(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-ethoxyethyl)sulfonyl]benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(phenylsulfonyl)methyl]acrylamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(3,5-dichlorobenzyl)-2-hydroxypropyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)sulfonyl]benzamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]acrylamide;
• N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-5-carboxamide 1,1-dioxide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-[(dipropylamino)carbonyl]-beta-alaninamide;
• N1-{(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N5,N5-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-5-carboxamide 1,1-dioxide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(dipropylamino)carbonyl]glycinamide;
• benzyl (4R)-4-{[((1S,2R)-1-benzyl-3-([3-(dimethylamino)-2,2-dimethylpropyl]amino}-2-hydroxypropyl)amino]carbonyl}-1,3-oxazolidine-3-carboxylate compound with methyl hydroperoxide (1:2);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1-benzothiophene-6-carboxamide 1,1-dioxide;
• tert-butyl (2R,3S)-2-hydroxy-3-({2-hydroxy-3-[(3-methoxyphenyl)sulfonyl]propanoyl}amino)-4-phenylbutyl(3-methoxybenzyl)carbamate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-6-carboxamide 1,1-dioxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-2,3-dihydro-1,2-benzisothiazole-5-carboxamide 1,1-dioxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-6-carboxamide 2,2-dioxide;
• N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-[3-(benzyloxy)-5-fluorobenzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-[3-(benzyloxy)benzyl]-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(dipropylamino)sulfonyl]propanamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-3-(benzylamino)-1-(cyclohexylmethyl)-2-hydroxypropyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-{(1S,2R)-3-(benzylamino)-1-[3-(benzyloxy)benzyl]-2-hydroxypropyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-3-[hydroxy(2-methylphenyl)methyl]-5-methylbenzamide;
• N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1R,2S)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1R,2S)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(4-methylbenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 3-chloro-N-{(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}benzamide;
• 3-chloro-N-((1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)benzamide;
• benzyl (2R,3S)-4-(3,5-difluorophenyl)-3-[(3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanoyl)amino]-2-hydroxybutyl(3-ethylbenzyl)carbamate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-7-(1H-imidazol-1-yl)-5,6-dihydronaphthalene-2-carboxamide;
• 2-{[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}-N,N-dipropylethanesulfonamide;
• benzyl (2R,3S)-4-(3,5-difluorophenyl)-2-hydroxy-3-({N-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]alanyl}amino)butyl(3-ethylbenzyl)carbamate;
• N1-[(1S,2R)-3-{[(benzyloxy)carbonyl](3-ethylbenzyl)amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,3]oxazolo[4,5-b]pyridin-2-ylthio)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(imidazo[1,2-a]pyridin-2-ylmethyl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(5,7-dimethyl[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dioxoisoindoline-5-carboxamide;
• 1-benzyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)thiophene-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isobutyl-1,3-dioxoisoindoline-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-2-phenylpyrazolidine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,4-difluorobenzyl)oxy]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylthieno[2,3-c]pyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-methyl-1H-benzimidazol-1-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxopyrrolidin-1-yl)-4-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-b]pyridine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1H-indol-1-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dioxooctahydro-2H-isoindol-2-yl)butanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[(4-methylphenyl)sulfonyl]-beta-alaninamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-indol-3-yl)-4-oxobutanamide;
• N2-(anilinocarbonothioyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole-3-carboxamide;
• 4-[2-(diethylamino)ethoxy]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(4-methylphenyl)sulfonyl]glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dioxo-1,2,4-triazolidin-4-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxyethoxy)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1,3-dithian-2-yl)-3-furamide;
• 4-(3-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxobutanamide or 2479;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5,6,7, 8-tetrahydro-4H-pyrazolo[1,5-a]azepine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-2-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7-fluoro-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-fluoro-4-methoxyphenyl)-4-oxobutanamide;
• methyl 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxobutyl-(dithiocarbamate);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methylphenyl)sulfonyl]acetamide;
• 3-(2-chlorophenyl)-2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methylphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-hydroxy-5-methylphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-thien-2-ylbutanamide or 2379;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-hydroxybenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dioxopyrrolidin-1-yl)benzamide;
• 4-[(aminocarbonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(trifluoroacetyl)amino]butanamide;
• 5-bromo-N1-((1S,2R)-2-hydroxy-1-(pentafluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(1-hydroxycyclopentyl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-oxocyclohexyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-naphthyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1H-indazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(dimethylamino)sulfonyl]valinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-furyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-4-phenyl-1,3-oxazol-2-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dioxohexahydropyrimidine-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5,7-dimethoxy-1-oxoindane-2-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5-(2-pyridin-2-ylethyl)pentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[4-(2-furoyl)piperazin-1-yl]-4-oxobutanamide;
• N′-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-[(1Z)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxo-1-(thien-2-ylmethyl)pyrrolidine-3-carboxamide;
• 2-[(cyanomethyl)thio]-N-((1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyllnicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furoyl)-4-hydroxyprolinamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydrofuro[2,3-g][2,1]benzisoxazole-8-carboxamide;
• methyl 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylthiophene-2-sulfenate;
• 2-(acetylamino)-2-(1H-1,2,3-benzotriazol-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• 1-([(cyclohexylamino)carbonyl]amino}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}cyclopropanecarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethyl-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)acetamide;
• (2E)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-[4-(1,3-oxazol-5-yl)phenyl]but-2-enediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-carboxamide;
• 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1-oxidothiomorpholin-4-yl)butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-(2-thioxo-1,3-benzothiazol-3(2H)-yl)butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8H-thieno[2,3-b]indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4H-chromeno[3,4-d]isoxazole-4-carboxamide;
• 4-(3,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methyl-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-difluorophenyl)-2-methoxy-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-[3-(trifluoromethyl)phenyl]butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-oxo-4-thien-2-ylbutanamide;
• 4-(3,4-dichlorophenyl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-3-methyl-4-oxobutanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-ethyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)oxy]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoisoindoline-1-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(7-methoxy-1-benzofuran-2-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4H-chromeno[3,4-d]isoxazole-8-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-4-oxo-4H-chromene-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-([1,2,4]triazolo[4,3-b]pyridazin-6-ylthio)acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(1,1-dioxidotetrahydrothien-2-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,4-dihydro-2H-chromen-6-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxoisoindoline-1-carboxamide;
• 4-[2-(acetylamino)-4,5-dimethylphenyl]-N-J(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-hydroxyphenyl)-4-oxobutanamide;
• 2-[(6-chloro[1,2,4]triazolo[4,3-b]pyridazin-3-yl)oxy]-N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(3-methoxyphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-hydroxy-4-oxo-4-thien-3-ylbutanamide;
• 3-chlorophenyl 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxobutanoate;
• 4-(4-chloro-2-hydroxyphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-{[(4-methylphenyl)sulfonyl]amino}-4-oxohexanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(6-hydroxy-3-oxo-2,3-dihydroimidazo[2,1-b][1,3]thiazol-2-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4,5-dihydro-1,3-thiazol-2-ylthio)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-imidazo[1,2-b]pyrazole-6-carboxamide;
• 4-(1-benzofuran-2-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(6-methoxy-1,1′-biphenyl-3-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-(4-methoxyphenyl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-9-oxo-1,2,3,9-tetrahydrocyclopenta[b]chromene-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-benzo[g]indazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dihydronaphtho[2,1-d]isoxazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(tetraazolo[1,5-b]pyridazin-6-ylthio)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-pyrrol-2-yl)-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}butanamide;
• N-[(1S,2R)-3-(2-acetyl-1-ethylhydrazino)-1-benzyl-2-hydroxypropyl]-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzamide;
• N1-[(1S,2R)-3-[(2-[4-[(3-chlorobenzyl)oxy]phenyl}ethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-morpholin-4-ylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• ethyl 4-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}piperidine-1-carboxylate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N-[(methylsulfonyl)acetyl]-N2-pentylglycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}propanamide;
• ethyl 4-([(2R,3S)-3-([3-[(dipropylamino)carbonyl]benzoyl}amino)-2-hydroxy-4-phenylbutyl]amino}piperidine-1-carboxylate;
• N1-((1S,2R)-1-benzyl-3-([(3R)-1-benzylpyrrolidin-3-yl]amino}-2-hydroxypropyl)-N3,N3-dipropylisophthalamide;
• methyl (2E)-2-[2-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-2-oxoethyl]-4-methylpent-2-enoate;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N4-(4-methoxybenzyl)succinamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(4-fluorophenyl)sulfonyl]amino}-3-methylbutanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(benzyloxy)benzamide;
• N′-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N-methyl-N-phenylurea
• N′-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-diisopropylurea
• N′-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-diphenylurea
• N′-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N,N-dimethylurea
• methyl 2-{[([(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]amino}benzoate;
• phenyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• 2-methoxyethyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• 2-(benzyloxy)ethyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• prop-2-ynyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• pentyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• neopentyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate;
• N1-[(1S,2R)-3-{[(6-chloroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4-oxo-4H-chromen-3-yl)methyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzamide;
• N1-[(1S,2R)-3-[(1-acetylpiperidin-3-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethoxy-5-methylisophthalamide;
• N1-(allyloxy)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isobutoxy-5-methylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-(2,2,3,3,3-pentafluoropropyl)isophthalamide;
• ethyl 4-({3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-5-methylbenzoyl}amino)butanoate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-bis (2,2,2-trifluoroethyl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-[(1-ethylpiperidin-4-yl)carbonyl]-5-methylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2,2,3,3,4,4,4-heptafluorobutyl)-5-methylisophthalamide;
• N1-(1-benzylpyrrolidin-3-yl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-ethyl-5-methylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-(tetrahydrofuran-2-ylmethyl)isophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxoazepan-3-yl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[2-(4-methylpentanoyl)hydrazino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-ethylphenyl)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2,3,3,4,4-hexafluoro-N5,N5-dipropylpentanediamide;
• N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-phenyl-N1,N1-dipropylpentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzamide;
• 5-bromo-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(trifluoromethyl)sulfonyl]amino}benzamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(thien-2-ylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)amino]benzamide;
• 4-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-4-oxo-3-{[(1-propylbutyl)sulfonyl]methyl}butanoic acid trifluoroacetate;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-[(methylsulfonyl)amino]-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]propanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropyl-5-{[(trifluoromethyl)sulfonyl]amino}isophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(isopentylsulfonyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}benzamide tri;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(trifluoromethyl)sulfonyl]amino}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxyethyl)(propyl)amino]sulfonyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}benzamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(3-hydroxypropyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]alaninamide;
• N1-{(1R,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N2-benzyloxycarbonyl-3-[(1-propylbutyl)sulfonyl]alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(3-methylisoxazol-4-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[2-(methylamino)ethyl]aminosulfonyl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthala;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)amino]butanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperazin-1-ylsulfonyl)-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[methyl(methylsulfonyl)amino]benzamide;
• 5-([bis (2-hydroxyethyl) amino]sulfonyl}-N1-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;
• 2-{[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}ethyl 2,4-difluorophenylcarbamate;
• 5-(aminosulfonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(1H-pyrazol-4-yl)isophthala;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyisoxazole-5-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1-methyl-1H-imidazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl)-5-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)amino]sulfonyl}-N3-propylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1S)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diethyl-5-(1,3-oxazol-2-yl)isophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(1R)-2-hydroxy-1-methylethyl]amino}sulfonyl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-2-hydroxy-1-(2,3,5-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethyl-1-hydroxybutyl)benzammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)sulfonyl]-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[1-(aminocarbonyl)cyclohexyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[2-(aminosulfonyl)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-methylhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-hydroxypropyl)amino]propyl}-5-methyl-N3,N 3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2-ethylhexyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-phenylbutyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-hydroxypentyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-hydroxyhexyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-[(3-butoxypropyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2R)-2-hydroxypropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N3-ethyl-N3-methyl-5-(1,3-oxazol-2-yl)isophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(pyrrolidin-1-ylsulfonyl)isophthalamide hydrochlormide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-5-yl)-N3,N3-dipropylisophthalamide hydrochlormide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide hydrochlormide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-oxazol-2-yl)isophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dimethyl-5-(1,3-oxazol-2-yl)isophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(1-propylbutyl)amino]sulfonyl}propanammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(isobutylamino)propyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide hydrochlormide;
• 5-bromo-N1-((1S,2R)-1-[3-fluoro-4-(trifluoromethyl)benzyl]-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalammide;
• 5-bromo-N1-((1S,2R)-2-hydroxy-1-(2,3,4-trifluorobenzyl)-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalammide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)-5-methylbenzamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-[(2-propylpiperidin-1-yl)carbonyl]benzamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-[(2-methylpyrrolidin-1-yl)carbonyl]benzamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2,6-dimethylpiperidin-1-yl)carbonyl]-5-methylbenzamide hydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-methoxyethyl)amino]sulfonyl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide dihydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-([(2-hydroxyethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(2-propylpentanoyl)benzamide hydrochlormide;
• N1-(sec-butyl)-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N1-propylisophthalammide;
• N1-butyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-methyl-N1-propylisophthalammide;
• N1-allyl-N1-cyclopentyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;
• N1,N1-dibutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-diisobutyl-5-methylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1Z)-prop-1-enyl]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(ethylsulfonyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-(1-(3,5-difluorobenzyl)-3-{[2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalammide;
• N1-[(1S,2R)-3-[(1,1′-biphenyl-3-ylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalammide;
• N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N1-ethyl-5-methylisophthalammide;
• N1-[(1S,2R)-3-{[3-(1-benzothien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3 N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-thien-3-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3 dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyridin-4-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2,4-dimethoxypyrimidin-5-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3,5-dimethylisoxazol-4-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide;
• N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N ,N 3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-ethynyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N3, N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• methyl 3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl(methyl)carbamate;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[methyl(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalammmide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2-isobutyl-1,3-thiazol-5-yl)methyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-ethynyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)(oxo)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(1E)-hex-1-enyl]benzyl}amino)-2-hydroxypropyl]-5-methyl-N3, N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[3-(5-acetylthien-2-yl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-[(3-allylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-3-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N-[(1S,2R)-3-{[(2-tert-butylpyrimidin-4-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N4-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide;
• N1-[(1S,2R)-3-[(3-butylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pentylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pent-4-enylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-cyclopentylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(3-cyclohexylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[3-(cyclohexylmethyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-hex-5-enylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• methyl (2S)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-([3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(3-methylthien-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3 dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(4-methylpyridin-2-yl)benzyl]amino propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(5-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-([3-(4-chlorobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[3-(3-cyanopropyl)benzyl]amino-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[3-(4-cyanobutyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[3-(6-cyanohexyl)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([3-(6-methylpyridin-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1,3-oxazol-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• methyl 3-{[((2R,3S)-4-(3,5-difluorophenyl)-3-{[3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoyl]amino}-2-hydroxybutyl)amino]methyl}phenyl(methyl)carbamate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl) amino]propyl}-N1,5-dimethylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{methyl[(trifluoromethyl)sulfonyl]amino}-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[methyl(methylsulfonyl)amino]-N3,N3-dipropylisophthalammide;
• N1-butyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)-N1,5-dimethylisophthalammide;
• N1-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• 5-bromo-N1-((1S,2R)-1-(2,4-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-ethylpiperidin-1-yl)sulfonyl]propanammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-ethynyl-N3,N3-dipropylisophthalammide;
• N1-cyclobutyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;
• N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-pentylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-isopentyl-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-(2-hydroxyethyl)-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N3-(2-ethoxyethyl) -5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-methoxyethyl)-N3,5-dimethylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-furylmethyl)-N3,5-dimethylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{(2R,5R)-2,5-dimethylpyrrolidin-1-yl]carbonyl}-5-methylbenzammide;
• N1-cyclopentyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,5-dimethyl-N3-pentylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-hydroxyethyl)-5-methyl-N3-propylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-N3-(2-methoxyethyl)-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-(2-methylcyclohexyl)isophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-methoxyethyl)-5-methyl-N3-propylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-bis(2-methoxyethyl)-5-methylisophthalammide;
• N1-allyl-N1-cyclohexyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipentylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-bis(2-ethoxyethyl)-5-methylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-naphthylmethyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-butyl-N3-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-N1,5-dimethylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(2S)-tetrahydrofuran-2-ylmethyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(3-hydroxypropyl)sulfonyl]-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-4-yl)-N3,N3-dipropylisophthalamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-isoxazol-3-yl-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-(1,3-oxazol-2-yl)benzammide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N2, N2-dipropylpyridine-2,4-dicarboxammide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxammide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N ,N 2-dipropylpyridine-2,4-dicarboxammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[methyl(thien-2-ylsulfonyl)amino]-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2R)-2-hydroxypropyl]amino)sulfonyl)-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-N5,N5-dipropylpentanediammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-dipropylamine-2-oxoethoxy)acetammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2-dipropylamine-2-oxoethyl)thio]acetammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(isobutylamino)-1,1-dimethyl-2-oxoethyl]amino}propyl)-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]benzammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-methyl-5-(2-methylpentanoyl)benzamide hydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-[(methylsulfonyl)amino]-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide dihydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-propionyl-3-[(1-propylbutyl)sulfonyl]-D-alaninammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino)propyl)-N,N-dipropyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}propyl)-N-methyl-N-propyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N1-butyl-N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-hydroxypropyl)(methylsulfonyl)amino]benzammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfonyl)benzammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(1-oxobutyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-pyrimidin-2-ylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-({[(2S)-2-hydroxypropyl]amino}sulfonyl)-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-N3-propyl-5-(1,3-thiazol-2-yl)isophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-methylpentanoyl)-5-(1,3-oxazol-2-yl)benzammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(3-hydroxypropyl)(methylsulfonyl)amino]benzammide;
• N2-acetyl-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;
• 2-[allyl(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-5-carboxammide;
• 3-(butylsulfonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-alaninamide bis(trifluoroacetate);
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninam;
• bis(trifluoroacetate);
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-isobutyryl-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;
• N-[(1S,2R)-3-(butylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-(ethylthio)benzammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxammide;
• N1-(4-tert-butyl-1,3-thiazol-2-yl)-N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinammide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-(1-hydroxy-2,2-dimethylpropyl)pyridine-2-carboxammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(ethylamino)carbonyl]amino}benzammide;
• 3-(1-cyanoethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzammide;
• 1-(cyanomethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-pyrrole-2-carboxammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1H-imidazol-1-yl)propyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(2R)-1-ethylpyrrolidin-2-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• 3-acetyl-N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]benzammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N 3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2E)-hex-2-enylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N 3, N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N5-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-N1,N1-dipropylpentanediammide;
• N1-{(1S,2R)-1-{[5-(cyanomethyl)-1H-imidazol-1-yl]methyl}-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-pyrimidin-2-ylisophthalammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(2,2-dimethylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D-alaninamide hydrochlormide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-{[ethyl(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzammide;
• 5-bromo-N1-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N3,N3-dipropylisophthalamide hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxammide;
• N3-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(5-methyl-1,2,4-oxadiazol-3-yl)-N3,N3-dipropylisophthalamide hydrochlormide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxammide;
• 3-(butylsulfonyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylmalonammide;
• N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylbieyclo[2.2.1]hept-5-ene-2,3-dicarboxammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylcyclopentane-1,3-dicarboxammide;
• N2-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N5,N5-dipropylthieno[2,3-b]thiophene-2,5-dicarboxammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-phenyl-N5,N5-dipropylpentanediammide;
• N2-benzyl-N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[2-(dipropylamino)-2-oxoethyl]glycinammide;
• 3-(4-chlorophenyl)-N′-{(1S, 2R) -1-(3,5-difluorobenzyl) -3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5,N5-dipropylpentanediammide;
• (2E)-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(methoxyimino)-N1,N1-dipropylpentanediammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl})N2,N2-(dipropylamino)-2-oxoethyl]-N2-phenylglycinammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)}N2,N2-dipropylcyclohexane-1,2-dicarboxammide;
• N1-[(1S,2R)-3-[(benzyloxy)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenylpropanammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-2-yl)-N3,N3-dipropylisophthalammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-hydroxy-2-propylpentyl)benzammide;
• N-[(1R,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyrylbenzammide;
• hydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-propylpentanoyl)benzammide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylbutanoyl)benzamide hydrochlormide;
• N3-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-ylamino)propyl]-N5,N5-diisopropylpyridine-3,5-dicarboxammide;
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-t[(1S)-2-(ethylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalammide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N3 N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-{[(1S)-2-(benzylamino)-1-methyl-2-oxoethyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalammide;
• N′-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N2,N2-dipropylcyclopropane-1,2-dicarboxammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N2,N2-dipropylcyclopropane-1,2-dicarboxammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-N5,N5-dipropylpentanediammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,3-dimethyl-N5,N5-dipropylpentanediammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-ethyl-3-methyl-N5,N5-dipropylpentanediammide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-methyl-N5,N5-dipropylpentanediammide;
• 2-[allyl(methylsulfonyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-oxazole-4-carboxammide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[2-(dimethylamino)ethyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-({2-[bis(2-hydroxyethyl)amino]ethyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalammide;
• N1-[(1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-3-[(1-propylbutyl)sulfonyl]-D-alaninamide dihydrochlormide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[4-(hydroxymethyl)-1,3-oxazol-2-yl]benzamide hydrochlormide;
• or a pharmaceutically acceptable salt thereof.

A compound of the formula:

• 1656
• wherein
• Ra and Rd are independently C1-C6 alkyl;
• X is O or S;
• Rb and Rc are independently hydrogen or halogen;
• Re is C1-C6 alkyl or an optionally substituted phenyl.

A compound of the formula:

• 1657
• wherein
• Ya is
• 1658
• or —N(CH2CH2CH3)2;
• Rf and Rg are both hydrogen or together with the carbon to which they are attached form a carbonyl;
• Xa is a covalent bond or a carbonyl;
• Rn is hydrogen or hydroxy;
• Ri and Rj are independently hydrogen or a halogen;
• Rk is C1-C6 alkyl;
• Rl is C1-C6 alkyl or an optionally substituted phenyl;
• and
• m is 0 or 1.

A compound which is:

• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-hydroxyethyl)(methylsulfonyl)amino]benzamide;
• 5-bromo-N1-{(1S,2R)-1-(2,4-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(2-methoxyethyl)(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(methylsulfonyl)methyl]benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(4-hydroxybutyl)sulfonyl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(dipropylamino)isoquinoline-7-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2-hydroxyethyl)(methyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(ethylamino)sulfonyl]-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(5-methyl-1,2,4-oxadiazol-3-yl)-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N3,N3-dipropylmalonamide;
• N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylcyclopentane-1,3-dicarboxamide;
• N2-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dimethyl-N5,N5-dipropylthieno[2,3-b]thiophene-2,5-dicarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-N5,N5-dipropylpentanediamide;
• N2-benzyl-N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[2-(dipropylamino)-2-oxoethyl]glycinamide;
• 3-(4-chlorophenyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N5,N5-dipropylpentanediamide;
• (2E)-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(methoxyimino)-N1,N1-dipropylpentanediamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[2-(dipropylamino)-2-oxoethyl]-N2-phenylglycinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2,N2-dipropylcyclohexane-1,2-dicarboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-phenylpropanamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1H-imidazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-6-carboxamide;
• 5-[(tert-butylamino) sulfonyl]-N1-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-butyl-N3-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-N3-propyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(4-methyl-1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalamide;
• N1-butyl-N3-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-methyl-5-(1,3-oxazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-ethyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;
• and
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 5-{[tert-butyl(methyl)amino]sulfonyl}-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-6-carboxamide;
• (2S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-(1-naphthyl)ethanamide;
• (2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-(1-naphthyl)ethanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isonicotinamide;
• N1-{(1S,2R)-1-benzyl-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-methyl-5-(1,3-oxazol-2-yl)-N3-propylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[1-(ethoxymethyl)-1H-imidazol-2-yl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-isopropyl-1,3-benzoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[ethyl(methyl)amino]sulfonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-methyl-1,3-benzoxazole-5-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(methylsulfonyl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-7-carboxamide;
• methyl 3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]benzoate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2,N2-dipropylcyclohexane-1,2-dicarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[ethyl(methyl)amino]sulfonyl}benzamide (1:1);
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-dimethylbenzamide;
• N1-butyl-N3-((1S, 2R) -1-(3,5-difluorobenzyl) -3-{[1-(3-ethynylphenyl) cyclopropyl]amino]-2-hydroxypropyl)-N1-methyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-butyl-N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N1-methylpentanediamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N5,N5-dipropylpentanediamide;
• (2R)-N5-{((S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-methyl-N1,N1-dipropylpentanediamide;
• (2S)-N5-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-N1,N1-dipropylpentanediamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4,N4-dipropylsuccinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[2-(dipropylamino)-2-oxoethyl]-N2-methylglycinamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[2-(dipropylamino)-2-oxoethyl]glycinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[2-(methoxymethyl)pyrrolidin-1-yl]-5-oxopentanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5-(2-furylmethyl)-N5-methylpentanediamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-benzoxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-1,3-benzoxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{dihydroxy[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-lambda4-sulfanyl]benzamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-propyl-1H-indole-6-carboxamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[4-(2-hydroxyethyl)-1,3-oxazol-2-yl]benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl) amino]propyl}-N3,N3-dipropyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4-ethylpyridin-2-yl)methyl]amino)-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(ethoxymethyl)benzamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indoline-6-carboxamide;
• 3-[(tert-butylamino)sulfonyl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3-dihydro-1,4-benzodioxine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-pyridin-4-ylisophthalamide;
• N1-butyl-N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• 3-(1-butyl-1H-pyrazol-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-1H-indazole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-thien-2-yl-1,3-thiazole-4-carboxamide;
• 5-(aminosulfonyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide;
• N-[(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(2-furylmethyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-{[(4-fluorobenzyl)sulfonyl]methyl}-1,3-thiazole-4-carboxamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]-1H-indole-6-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;
• N1-butyl-N3-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-N1-methyl-5-(1,3-thiazol-2-yl)isophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(ethylamino)sulfonyl]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylamino)sulfonyl]benzamide;
• (2E)-3-(1-butyl-1H-pyrazol-4-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}prop-2-enamide or (2E)-3-(1-butyl-1H-pyrazol-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}prop-2-enamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(propylamino)isoquinoline-7-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-{[(2-hydroxy-1,1-dimethylethyl)amino]sulfonyl}-N3,N3-dipropylisophthalamide;
• methyl 3-(2-{3-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-1,3-oxazol-5-yl)propanoate;
• 3-(2-(3-[(((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]phenyl}-1,3-oxazol-5-yl)propanoic acid;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(3-hydroxypropyl)-1H-indole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-ethoxybenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(pyrrolidin-1-ylcarbonyl)isonicotinamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(6-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N , N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)sulfonyl]benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(6-ethylpyridin-2-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• tert-butyl (1R)-1-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-3-(methylsulfinyl)propylcarbamate;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)isonicotinamide;
• (2R)-2-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(methylsulfinyl)butanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[ethyl(methyl)amino]sulfonyl}-5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[methyl(propyl)amino]isoquinoline-7-carboxamide or N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-[methyl(propyl)amino]isoquinoline-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-oxazol-2-yl)benzamide;
• N1-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N3,N3-dipropyl-1H-pyrazole-3,5-dicarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N2,N2-dipropylcyclobutane-1,2-dicarboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(dipropylamino)carbonothioyl]benzamide;
• 3-[(E)-(cyanoimino)(dipropylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-propylbutoxy)benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(5-ethylpyridin-3-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-methoxyethyl)-1H-indole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-{(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-thiazol-2-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-diethoxyquinoline-2-carboxamide;
• 2-(4-butyl-3-oxopiperazin-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[2-(dimethylamino)ethyl]-N3, 5-dimethylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methylbutanoyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(4-methylpentanoyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• isobutyl (2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutylcarbamate;
• ethyl (2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutylcarbamate;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(pyrimidin-2-ylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-methyl-N3-[(1S)-1-methylpropyl]isophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-N3-[(1R)-1-methylpropyl]isophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylpyrimidine-4-carboxamide;
• 1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isoquinoline-7-carboxamide or 1-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]isoquinoline-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-dihydro-2-benzothiophene-5-carboxamide 2,2-dioxide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-({[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide trifluoroacetate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isobutyl-1H-indole-6-carboxamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-indole-6-carboxamide;
• 1-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1H-indole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-oxazol-2-yl)-1H-indole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-methylisonicotinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)methyl]-1,3-thiazole-4-carboxamide;
• 4-amino-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;
• 3-[(tert-butylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;
• 3-{[(2S)-2-butylpyrrolidin-1-yl]carbonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
• 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[(2R)-2-(propoxymethyl)pyrrolidin-1-yl]carbonyl}benzamide;
• 2-(1-butyl-2-oxopiperidin-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-pentylbenzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-ethylhexyl)benzamide;
• ethyl 5-{3-[([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylamino)carbonyl]phenyl}-2-furoate;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-21-(methylthio)-1,11-biphenyl-3-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-fluorobenzyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-fluorobenzyl)benzamide;
• ethyl 3′-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1,1′-biphenyl-2-carboxylate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3′,5′-difluoro-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylacetamide;
• tert-butyl 4-[([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]benzylcarbamate;
• (2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-phenylethanamide;
• (2S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-2-phenylethanamide;
• 3-(5-chloropentyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-phenylethyl)benzamide trifluoroacetate;
• 3-(cyclohexylmethyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• 3-cyclopentyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hex-5-enylbenzamide;
• 3-(6-cyanohexyl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(2-formylthien-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formylthien-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(6-methoxypyridin-2-yl)benzyl]amino}propyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[3-(5-cyanopyridin-3-yl)benzyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(6-fluoropyridin-3-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrimidin-4-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-ethylpyrimidin-2-yl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-pyrimidin-2-ylbenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• methyl 2-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]-6-methylisonicotinate;
• N4-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide 1-oxide;
• 1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;
• 1-butyl-4-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;
• 5-(diethylamino)-N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[3-(diethylamino)benzyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3 dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(dimethylamino)-N3,N3-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyridin-4-yl)methyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N2-(tert-butoxycarbonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-norleucinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methyl]benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[ethyl(propyl)amino]methyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1,3-dihydro-2,1-benzisothiazole-5-carboxamide 2,2-dioxide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-norleucinamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(dimethylamino)benzyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 2-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylisonicotinamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[(2-hydroxyethyl)(propyl)amino]methyl}benzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-fluoro-4-propoxyphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(3-methoxy-4-propoxyphenyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-methyl-5-{[methyl(propyl)amino]methyl}benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-[(dipropylamino)methyl]-5-methylbenzamide;
• 3-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(piperidin-1-ylsulfonyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-3-methylbenzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(3-methoxypropyl)benzamide;
• 5-amino-N1-{(1S, 2R) -1-(3,5-difluorobenzyl) -3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({3-[(dimethylamino)methyl]benzylamino)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-(tert-butoxycarbonyl)-3-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-L-histidinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-isopentyl-1H-indole-6-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-ethyl-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide;
• 6-bromo-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]cyclohexanecarboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperidin-4-yl-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(1,3-oxazol-2-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]thiophene-2-carboxamide;
• 3-[(cyclohexylamino)methyl]-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
• 2-(2-chlorophenoxy)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(phenylsulfonyl)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]-6-methylisonicotinamide;
• 3-[({(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)carbonyl]-5-methylbenzoic acid;
• 6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethylchromane-8-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(1,3-thiazol-2-yl)benzamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-ethoxyphenyl)acetamide (1:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[(2S)-2-propylpyrrolidin-1-yl]carbonyl}benzamide (1:1);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2R)-2-(2-methoxyethyl)pyrrolidin-1-yl]carbonyl)-5-methylbenzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methylsulfonyl)methyl]cyclohexanecarboxamide;
• 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-5-carboxamide;
• formic acid compound with 2-(1-butyl-2-oxo-1,2-dihydropyridin-4-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1:1);
• 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-histidinamide;
• 5-[(diethylamino)methyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(dimethylamino)methyl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}-3-(1,3-oxazol-2-yl)benzamide;
• formic acid compound with N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-hydroxy-4-methoxyphenyl)acetamide (1:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,3-thiazolidin-3-ylsulfonyl)benzamide (1:1);
• formic acid compound with N-((1S,2R)-1-(3,5-idifluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzamide (1:1);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(4-phenylpiperazin-1-yl)sulfonyl]benzamide;
• 3-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;
• N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}acetamide;
• 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(methylsulfonyl)methyl]nicotinamide;
• N1-[(1S,2R)-3-({3-[(diethylamino)methyl]benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-6-(1,3-oxazol-2-yl)isonicotinamide;
• 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-benzimidazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]propyl}-3-methylbenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperidin-3-yl-N3,N3-dipropylisophthalamide;
• 3-{[benzyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
• formic acid compound with N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-([4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}benzamide (2:1);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pyrrolidin-1-ylsulfonyl)benzamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(pyrrolidin-1-ylsulfonyl)benzamide (1:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-([4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)benzamide (2:1);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide;
• formic acid compound with N-[((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dimethylamino)sulfonyl]benzamide (1:1);
• N-{(1S,2R)-3-[(3-ethylbenzyl)amino]-1-[3-(hexyloxy)benzyl]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[(methylsulfonyl)methyl]nicotinamide;
• N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-methylpentanamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1H-pyrrole-2-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1H-pyrrol-2-ylmethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-piperazin-1-yl-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;
• N2-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-N4,N4-dipropylpyridine-2,4-dicarboxamide;
• N2-(tert-butoxycarbonyl)-N1-{(S, 2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-norleucinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-norleucinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(4R)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-t[(4S)-6-isopropyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}propyl)acetamide;
• formic acid compound with 4-{[(4-chlorophenyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with 4-{[benzyl(phenyl)amino]sulfonyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(morpholin-4-ylsulfonyl)benzamide (1:1);
• N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]propanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-4-propylcyclohexyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,1-dipropyl-3,4-dihydro-1H-isochromene-7-carboxamide;
• formic acid compound with 4-{[(2-cyanoethyl)(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with 4-{[cyclohexyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-pyridin-2-ylethyl)amino]sulfonylbenzamide (2:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(phenyl)amino]sulfonyl}benzamide (1:1);
• formic acid compound with 4-{[benzyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(2-phenylethyl)amino]sulfonylbenzamide (1:1);
• formic acid compound with 4-{[allyl(methyl)amino]sulfonyl}-N-{(1S*,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with 4-{[[2-(diethylamino)ethyl](methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (2:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(propyl)amino]sulfonyl}benzamide (1:1);
• formic acid compound with 4-{[butyl(methyl)amino]sulfonyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(pentyl)amino]sulfonyl}benzamide (1:1);
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[isopentyl(methyl)amino]sulfonyl}benzamide (1:1);
• 2-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide;
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-{[methyl(1-methylpyrrolidin-3-yl)amino]sulfonyl}benzamide (2:1);
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethylpyridin-2-yl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-(2-methoxyethyl)benzamide;
• 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(2-methoxyethyl)-1H-benzimidazole-6-carboxamide;
• L-alpha-glutamyl-L-valyl-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-L-methioninamide;
• 3-([cyclohexyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3-butoxybenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• formic acid compound with 2-(4-butyl-2,5-dioxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1:1);
• 3-bicyclo[2.2.1]hept-2-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• 3-(butylamino)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-(1,3-oxazol-2-yl)isonicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}-3-methylbenzamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(dipropylamino)sulfonyl]benzamide (1:1);
• formic acid compound with 4-[(diethylamino)sulfonyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide (1:1);
• 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isoquinoline-7-carboxamide;
• 5-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;
• 3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;
• 3-{[butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl)-5-methylbenzamide;
• 3-bromo-5-([butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
• 3-{[butyl(methyl)amino]methyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-methylbenzamide;
• (2R)-2-(4-butyl-3-oxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• 3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-6-(1,3-thiazol-2-yl)isonicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3-butoxybenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;
• 3-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}imidazo[1,2-a]pyridine-6-carboxamide;
• 2-[butyl(methyl)amino]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-(1,3-oxazol-2-yl)isonicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-benzodioxole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl]acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[methyl(propyl)amino]-6-(1,3-oxazol-2-yl)isonicotinamide;
• 3-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1-phenylcyclopropyl)amino]propyl}-5-methylbenzamide;
• 3-{[butyl(methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-methylbenzamide;
• N-[(1S,2R)-3-{[1-(3-bromophenyl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;
• 3-([butyl(methyl)amino]methyl}-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(methylsulfonyl)-1-phenylethyl]amino}propyl)acetamide;
• 3-{[butyl(methyl)amino]methyl}-5-cyano-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({2-[(methylsulfonyl)methyl]benzyl}amino)propyl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-furylmethyl)(methyl)amino]methyl}-5-methylbenzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzamide;
• 3-{[[2-(diethylamino)ethyl](methyl)amino]methyl}-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
• N-[(1S,2R)-3-[(3-bromobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-2-methoxyacetamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(ethoxymethyl)piperidin-1-yl]pentanamide (2:1);
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoindane-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyindane-5-carboxamide;
• formic acid compound with N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-propoxypiperidin-1-yl)acetamide (2:1);
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[isobutyl(methyl)amino]methyl}-5-methylbenzamide;
• formic acid compound with 2-(1-butyl-2-oxopiperidin-4-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (1:1);
• formic acid compound with 2-(4-butylpiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide (3:1);
• 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([(1R,2s)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)acetamide;
• 2-[(2S)-4-butyl-2-methyl-3-oxopiperazin-1-yl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;
• 2-[(2R)-4-butyl-2-methyl-3-oxopiperazin-1-yl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dioxo-4-propylpiperazin-1-yl)acetamide;
• 4-butyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoxaline-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-{[methyl(pentyl)amino]methyl}benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-([(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl)-5-methylbenzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)isonicotinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1-{4-[(dimethylamino)methyl]pyridin-2-yl}cyclopropyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(dipropylamino)-4-methyl-1,3-thiazole-5-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({2-[(4-ethylbenzyl)sulfonyl]ethyl}amino)-2-hydroxypropyl]acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3,5-dimethylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]propyl}acetamide;
• 3-bromo-5-{[butyl(methyl)amino]methyl}-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[[-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1H-indole-6-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[({4-[(dimethylamino)methyl]pyridin-2-ylmethyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 3-[(butylamino)methyl]-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl}-5-methylbenzamide;
• formic acid compound with N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2-methoxyethyl)piperidin-1-yl]acetamide (2:1);
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroisoquinoline-7-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1,5-dimethyl-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)prop-1-ynyl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-phenoxyphenyl)acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,5-dimethylphenyl)acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(trifluoromethoxy)phenyl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-ethoxyphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[2-(trifluoromethyl)phenyl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methoxyphenyl)acetamide;
• 2-[2-(benzyloxy)phenyl]-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylbutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-mesitylacetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,4-dimethoxyphenyl)acetamide;
• 2-(2-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• 2-cyclohexyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• 2-cyclopent-2-en-1-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1-methyl-5-oxo-2-thioxoimidazolidin-4-yl)acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-fluorophenyl)acetamide;
• 2-cyclopropyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;
• 2-cyclohex-1-en-1-yl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylacetamide;
• 2-(1-adamantyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;
• (2S)-N-[,(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylpropanamide;
• (2R)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylpropanamide;
• 2-(2,4-dichlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylacetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,3-dimethoxyphenyl)acetamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropyl}acetamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethynylpyridin-2-yl)cyclopropyl]amino}-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide 1-oxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-heptyl-4-hydroxy-L-prolinamide;
• 2-[butyl(methyl)amino]-6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;
• 2-[butyl(methyl)amino]-6-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[({2-[(dimethylamino)methyl]pyridin-4-yl}methyl)amino]-2-hydroxypropyl}-5-(1,3-oxazol-2-yl)-N,AN-dipropylisophthalamide;
• 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide or 4-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-ethyl-1,3-oxazol-2-yl)-5-(1,3-oxazol-2-yl)benzamide;
• 3-benzyl-4-(4-butylphenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide;
• 2-(4-butyl-2-oxopiperazin-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(ethoxymethyl)piperidin-1-yl]acetamide;
• 2-(4-butyl-2,3-dioxopiperazin-1-yl)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}hexanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}acetamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(4-ethynylpyridin-2-yl)cyclopropyl]amino)-2-hydroxypropyl)-5-(1,3-oxazol-2-yl)-N3,N3-dipropylisophthalamide;
• 5-[((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)amino]-5-oxopentanoic acid;
• 1-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide or 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,3,4-tetrahydroquinoline-7-carboxamide;
• 4-(((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)amino]-4-oxobutanoic acid;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propyl-1,2-benzisoxazole-5-carboxamide;
• 2-[allyl(methyl)amino]-N-{(1S,2R)-1-[3-(allyloxy)-5-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;
• 1-allyl-N-{(1S,2R)-1-[4-(allyloxy)-3-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-6-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-phenyl-2-(1H-pyrrol-1-yl)-1,3-thiazole-5-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide;
• (2S)-2-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-N-isobutyl-4-(methylsulfonyl)butanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(3-hydroxyprop-1-ynyl)benzyl]amino}propyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-dimorpholin-4-ylpyrimidine-4-carboxamide;
• N-J(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-{[(2S)-2-ethylpyrrolidin-1-yl]carbonyl}-5-methylbenzamide;
• (2S)-2-(4-butyl-3-oxopiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)tetrahydrofuran-3-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)propanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-2-(1H-imidazol-4-yl)acetamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-N2,2-dimethylalaninamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)cyclopentanecarboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)cyclopropanecarboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-2-phenylacetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)tetrahydrofuran-2-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-t[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-1,3-thiazolidine-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxybutanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxypropanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-hydroxy-2,2-dimethylpropanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-methylbutanamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)glycinamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-N2-methylglycinamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide;
• 2-[allyl(methyl)amino]-N-((1S,2R)-1-[4-(allyloxy)-3-fluorobenzyl]-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}isonicotinamide;
• 3-butyl-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2-benzisoxazole-5-carboxamide;
• 5-(3-aminopropyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)propyl]-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(methylamino)prop-1-ynyl]-N3,N3-dipropylisophthalamide;
• 5-(3-aminoprop-1-ynyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-5-pyrrolidin-1-ylpyrazine-2-carboxamide;
• 4-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-2-carboxamide;
• 2-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-[methyl(propyl)amino]isonicotinamide;
• 3-acetyl-1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1H-indole-6-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(1H-indol-6-ylmethyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-isobutyl-1,2-benzisoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyli-2-[(2S)-pyrrolidin-2-yl]acetamide;
• 2-[2-([(1S,2R)-1-(3,5-.difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]-N-(6-methoxypyridin-3-yl)benzamide;
• 2-[2-([(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]-N-(2,4-difluorophenyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-ylacetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(1H-imidazol-5-yl)acetamide;
• 2-cyclopentyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-hydroxyphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-methylphenyl)acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2-iodophenyl)acetamide;
• 1-(4-chlorophenyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-oxopyrrolidine-3-carboxamide;
• 4-(2,4-dichlorophenoxy)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide;
• 4,5-dibromo-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2,6-bis(dimethylamino)pyrimidine-4-carboxamide;
• 4-butyl-8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide;
• 3-(allylsulfonyl)-N-((1S,2R) -1(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
• 3-(allylthio)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}acetamide;
• formic acid compound with N1-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-N5-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pentanediamide (1:1);
• formic acid compound with N1-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-N5-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pentanediamide (1:1);
• formic acid compound with N1-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)succinamide (1:1);
• formic acid compound with N1-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-N4-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)succinamide (1:1);
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)pentanamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-3-phenylpropanamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)but-1-ynyl]-N3,N3-dipropylisophthalamide;
• 1-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(trifluoroacetyl)-1H-indole-6-carboxamide;
• N-((1S,2R) -1(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-3-{[isopentyl(methyl)amino]methyl}-5-methylbenzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-4-(dipropylamino)-1-methyl-1H-pyrrole-2-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(4R)-6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl]amino}-2-hydroxypropyl)-4-(2-methoxyethyl)benzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[4-(dimethylamino)butyl]-N3,N3-dipropylisophthalamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[6-ethyl-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-4-yl]amino}-2-hydroxypropyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[6-ethyl-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-4-yl]amino}-2-hydroxypropyl)acetamide;
• 2,6-dichloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)pyrimidine-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1S)-7-ethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-2-hydroxypropyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(1R)-7-ethyl-1,2,3,4-tetrahydronaphthalen-1-yl]amino}-2-hydroxypropyl)acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-morpholin-4-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide;
• N-((1S,2R)-1-benzyl-3-[(6-ethyl-2,2-dioxido-3,4-dihydro-1H-isothiochromen-4-yl)amino]-2-hydroxypropylacetamide;
• N-[(1S,2R)-3-([1-(3-bromophenyl)cyclopropyl]amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-(([1-(3-ethylphenyl)-1H-tetraazol-5-yl]methyl}amino)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide;
• 3-(allylsulfinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)benzamide;
• methyl 3-[3′-(acetylamino)-1,1′-biphenyl-3-yl]-3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}propanoate;
• methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-[3-(5-formylthien-2-yl)phenyl]propanoate;
• methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(2′-acetyl-1,1′-biphenyl-3-yl)propanoate;
• methyl 3-([(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino)-3-[3′-(hydroxymethyl)-1,1′-biphenyl-3-yl]propanoate;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3′-methoxy-1,1′-biphenyl-3-yl)cyclopropyl]amino}propyl)acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3′-(hydroxymethyl)-1,1′-biphenyl-3-yl]cyclopropyl}amino)propyl]acetamide;
• N-[(1S,2R)-3-{[1-(2′-acetyl-1,1′-biphenyl-3-yl)cyclopropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-({1-[3-(5-formylthien-2-yl)phenyl]cyclopropyl}amino)-2-hydroxypropyl]acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-(9H-fluoren-9-ylamino)-2-hydroxypropyl]acetamide;
• methyl 3-([(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoate;
• methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-cyanophenyl)propanoate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[3-(dimethylamino)propyl]-N3,N3-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′-(hydroxymethyl)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 3′-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′-ethoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-3′-(trifluoromethoxy)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-propoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-(dimethylamino)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′-propoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′-propoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′-ethoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-ethoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-isopropoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-(hydroxymethyl)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 4′-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4′-methoxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-4′-(trifluoromethoxy)-1,1′-biphenyl-3-carboxamide;
• 4′-butyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 3′-butoxy-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3′-isopropyl-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 3′-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2′-methyl-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 2′-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4′-hydroxy-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• 4′-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(1,3-thiazol-2-yl)-1,1′-biphenyl-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1H-pyrrol-2-yl)-5-(1,3-thiazol-2-yl)benzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(E)-2-(4-fluorophenyl)ethenyl]-5-(1,3-thiazol-2-yl)benzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)pyrimidine-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)acetamide;
• methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-bromophenyl)propanoate;
• 2-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{11-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-6-morpholin-4-ylpyrimidine-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)-2-(dipropylamino)-6-morpholin-4-ylpyrimidine-4-carboxamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethynylphenyl)cyclopropyl]amino)-2-hydroxypropyl)-2,6-bis(dipropylamino)pyrimidine-4-carboxamide;
• methyl 3-{[(2R,3S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}-3-(3-bromophenyl)propanoate;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)acetamide;
• or pharmaceutically acceptable salts thereof.

A compound which is:

• N1-[(1S,2S)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;
• N-(1-cyclopropylethyl)-N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-phenylsuccinamide;
• N1-[(1S,2R) -1(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(1E)-prop-1-en-1-yl]benzyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide;
• methyl (3-{[((2R,3S)-4-(3,5-difluorophenyl)-3-{[3-[(dipropylamino)carbonyl]-5-(1,3-oxazol-2-yl)benzoyl]amino}-2-hydroxybutyl)amino]methyl}phenyl)methylcarbamate;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]-5-(1,3-oxazol-2-yl)-N,N-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-N,N-dipropylpyridine-3,5-dicarboxamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,N-dipropylpyridine-3,5-dicarboxamide 1-oxide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethynylbenzyl)amino]-2-hydroxypropyl}-5-ethynyl-N,N-dipropylisophthalamide;
• N4-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-isopropylbenzyl)amino]propyl}-6-methyl-N2,N2-dipropylpyridine-2,4-dicarboxamide;
• N1-[(1S,2R)-3-{[(2-tert-butylpyrimidin-4-yl)methyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylamino)propyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]aminopropyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-oxo-1-methyl-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-3-{[(1S)-1-benzyl-2-oxo-2-(methylamino)ethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[oxo [3-(trifluoromethyl)phenyl]methyl}glycinamide;
• 2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio}-N-(5-methylisoxazol-3-yl)acetamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[oxo(methylamino)methyl]-3-(methylthio)propyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R)-1-(hydroxymethyl)-2-oxo-2-(methylamino)ethyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-3-({(1S)-1-[amino(oxo)methyl]-3-methylbutyl}amino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-[(1S,2R)-3-[(2-amino-2-oxo-1-methylethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylcarbamate;
• tert-butyl (1S,2R)-3-(cyclopropylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate;
• tert-butyl (1S,2R)-3-[(cyclopropylmethyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropylcarbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([2-oxo-2-(isobutylamino)-1-methylethyl]amino}propyl)carbamate;
• benzyl (1S,2R)-1-benzyl-3-[(3-ethylbenzyl)amino]-2-hydroxypropylcarbamate;
• (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-([1-(3-ethynylphenyl)cyclopropyl]aminobutan-2-ol;
• tert-butyl [(1S,2R)-3-{[(1S)-2-(benzylamino)-2-oxo-1-methylethyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;
• N2-[(2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-N1-benzyl-L-alaninamide bis(trifluoroacetate) (salt);
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino propyl)carbamate;
• (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(2-isobutyl-1,3-thiazol-5-yl)cyclopropyl]amino}butan-2-ol bis(trifluoroacetate) (salt);
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}propyl)carbamate;
• (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[1-(3-isobutylisoxazol-5-yl)cyclopropyl]amino}butan-2-ol bis(trifluoroacetate) (salt);
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[(2-ethylpyrimidin-4-yl)methyl]amino}-2-hydroxypropyl)carbamate;
• (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-{[(2-ethylpyrimidin-4-yl)methyl]amino}butan-2-ol bis(trifluoroacetate) (salt);
• tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amino]propyl}carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylamino)propyl]carbamate;
• tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-hydroxy-1-phenylpropyl)amino]propyl}carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[oxo(isobutylamino)methyl]-3-(methylthio)propyl]aminopropyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-1-[(isobutylamino)carbonyl]-3-(methylsulfonyl)propyl]amino}propyl)carbamate;
• tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1,2-benzoxathiin-4-yl)amino]-2-hydroxypropyl}carbamate;
• tert-butyl f(1S,2R)-1-(3,5-difluorobenzyl)-3-[(2,2-dioxido-3,4-dihydro-1H-2,1-benzothiazin-4-yl)amino]-2-hydroxypropyl}carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethylphenyl)cyclopropyl]amino}-2-hydroxypropyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-{[1-(3-ethynylphenyl)cyclopropyl]amino}-2-hydroxypropyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-methylphenyl)cyclopropyl]amino}propyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-(3-iodophenyl)cyclopropyl]amino}propyl)carbamate;
• tert-butyl [(1S,2R)-3-{[3-(cyclopropylamino)benzyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;
• methyl 3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)benzoate;
• methyl [3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl]carbamate;
• methyl [3-({[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl]methylcarbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-([3-[(dimethylamino)sulfonyl]benzyl}amino)-2-hydroxypropyl]carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({3-[(methylsulfonyl)amino]benzyl}amino)propyl]carbamate;
• tert-butyl [(1S,2R)-3-[(3-cyanobenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;
• 3-(([(2R,3S)-3-[(tert-butoxycarbonyl)amino]-4-(3,5-difluorophenyl)-2-hydroxybutyl]amino}methyl)phenyl dimethylcarbamate;
• tert-butyl [(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl][3-(ethylthio)benzyl]carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1R)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}carbamate;
• tert-butyl {(1S,2R)-1-(3,5-difluorobenzyl)-3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2-hydroxypropyl}carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}propyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3S)-2-oxoazepan-3-yl]amino}propyl)carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxoazepan-3-yl]amino}propyl)carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5S)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl}amino)-2-hydroxypropyl]carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-3-({[(5R)-3-ethyl-2-oxo-1,3-oxazolidin-5-yl]methyl]amino)-2-hydroxypropyl]carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-3-([1-(3-ethylphenyl)-1-methylethyl]amino}-2-hydroxypropyl)carbamate;
• tert-butyl [(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(2-naphthylmethyl)amino]propyl}carbamate;
• tert-butyl ((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-([2-oxo-2-(isobutylamino)-1,1-dimethylethyl]amino}propyl)carbamate;
• tert-butyl [(1S,2R)-3-[(benzyloxy)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]carbamate;
• tert-butyl 4-[({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]piperidine-1-carboxylate trifluoroacetate;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;
• N-[(1S,2R)-1-benzyl-3-(2-butyryl-1-ethylhydrazino)-2-hydroxypropyl]-2-(3-methylisoxazol-5-yl)acetamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-hexyl-N,5-dimethylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzoyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3,3-dimethyl-N2,N2-dipropylcyclopropane-1,2-dicarboxamide;
• tert-butyl 2-[(((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)carbonyl]-1-methyl-1H-imidazol-4-ylcarbamate;
• N5-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethyl-N′,N1-dipropylpentanediamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(2-morpholin-4-ylethyl)amino]propyl}-2-(4-chlorophenoxy)-2-methylpropanamide compound with methyl hydroperoxide (1:2);
• N-[(1S,2R)-3-(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-4-fluoro-1-naphthamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-isopropylbenzyl)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(3-methoxybenzyl)propyl]propanamide;
• N1-[(1S,2R)-1-(3,5-dichlorobenzyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-3-(benzylamino)-2-hydroxy-1-(4-methoxybenzyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-1-(4-isopropylbenzyl)-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• 3-[(dipropylamino)sulfonyl]-N-((1S)-1-{(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}but-3-ynyl)propanamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N5,N5-dipropylpentanediamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-5-methyl-N3,N3-dipropylisophthalamide;
• N1-((1S)-1-[(1R)-1-hydroxy-2-[(3-methoxybenzyl)amino]ethyl}-3-methylbutyl)-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-1-(2-furylmethyl)-2-hydroxy-3-(isopentylamino)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N1-[(1S,2R)-2-hydroxy-3-[(3-methoxybenzyl)amino]-1-(1-naphthylmethyl)propyl]-N3,N3-dipropylbenzene-1,3,5-tricarboxamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-{[(2-methoxyethyl)(propyl)amino]sulfonylpropanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(4,5-dimethyl-2-furoyl)-5-methylbenzamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-2-hydroxy-3-(isopentylamino)-1-(4-methylbenzyl)propyl]propanamide;
• 3-[(dipropylamino)sulfonyl]-N-[(1S,2R)-1-(3-fluoro-5-hydroxybenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-1,3-benzothiazole-2-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide;
• N-[(1S,2R)-3-amino-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-3-(isopentylsulfonyl)propanamide trifluoroacetate;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-5-methylbenzamide;
• 4-amino-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]butanamide bis(trifluoroacetate);
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(pyridin-4-ylmethyl)thio]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-[(pyridin-2-ylthio)methyl]-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5-methyl-1H-tetraazol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,8-dimethylquinoline-3-carboxamide;
• 2-(3-chlorophenoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• 2-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1H-tetraazol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[5-(2-methylphenyl)-2H-tetraazol-2-yl]acetamide;
• 3-(1,3-benzoxazol-2-ylthio)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-6-methylquinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-propylpyrazine-2-carboxamide 4-oxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-indole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1,3-benzothiazole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-[(6-methoxy-1H-benzimidazol-2-yl)thio]acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenylthiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxythiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,3′-bithiophene-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-morpholin-4-yl-4-oxobutanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-3-carboxamide;
• 4-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,6-dimethylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-furamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-3,5-dimethoxybenzamide;
• 4-acetyl-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylinicotinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxyquinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxynicotinamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-benzothiophene-2-carboxamide;
• 7-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methylisoxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methylisoxazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methoxy-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-2-(methylthio)pyrimidine-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-oxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-1H-pyrazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-1,3-oxazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxybenzamide;
• 4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}benzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-piperidin-1-ylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methylpyrimidine-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}quinoline-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-7-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-hydroxy-4-methylpyridine-2-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4,N4-diphenylsuccinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[ethyl(methyl)amino]-4-hydroxypyrimidine-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,8-dihydroxyquinoline-2-carboxamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-benzofuran-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-1H-indole-2-carboxamide;
• 2-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,5-dimethylthiophene-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyquinoxaline-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-indazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-1,3-oxazole-4-carboxamide;
• 4-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methylquinoline-2-carboxamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyli-N2,N2-dimethylphthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-6-neopentylpyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-hydroxy-7-methoxy-1-benzothiophene-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxy-1-benzofuran-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenyl-1,3-oxazole-4-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,4-dihydroxybenzamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N4-phenylsuccinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N4-pyridin-3-ylsuccinamide;
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-(2,6-dimethylphenyl)succinamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N4-methylsuccinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methoxyphenoxy)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-7-methoxyquinoline-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[methyl(methylsulfonyl)amino]benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(pyrrolidin-3-ylsulfonyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-phenylimidazo[1,2-a]pyridine-6-carboxamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N5-(1,3-thiazol-2-yl)pentanediamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,2,3-thiadiazol-5-yl)thio]acetamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(piperidin-1-ylmethyl)-2-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-phenyl-1H-pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-fluoro-4-morpholin-4-ylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3,5-bis(methylthio)isothiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-5-(trifluoromethyl)isoxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-5-(propionylamino)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-phenyl-1H-pyrrole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}pyrazine-2-carboxamide 4-oxide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-1-pyridin-4-yl-1H-1,2,3-triazole-4-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxypyrazine-2-carboxamide 4-oxide;
• N-{(1S,2R)-1-(3′,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-5-phenyl-1H-pyrazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxy-3-propylhexanamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1H-benzimidazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(propionylamino)benzamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-1-benzofuran-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-yl-1,3-thiazole-4-carboxamide;
• 8-cyano-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxyquinoline-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,6-naphthyridine-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,2-dimethyl-4-oxochromane-6-carboxamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(morpholin-4-ylmethyl)benzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4,7-dimethoxy-1-benzofuran-5-carboxamide;
• 3-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-phenylisothiazole-4-carboxamide;
• 2-(2,1,3-benzothiadiazol-4-yloxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methoxy-4-(methylthio)benzamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(4-methyl-1,3-thiazol-2-yl)thio]acetamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methoxy-1-benzofuran-2-carboxamide;
• 5-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-morpholin-4-ylbenzamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxy-1H-pyrrole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-1,3-thiazole-4-carboxamide;
• N-{(1S,2R) -1(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-methyl-5-(2-thienyl)-3-furamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methoxythiophene-3-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N1-(3,5-dimethylpyrazin-2-yl)succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(3,4-dimethoxyphenyl)thio]acetamide;
• 6-chloro-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(trifluoromethyl)pyridine-2-carboxamide;
• N-(2-acetyl-3-thienyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropylysuccinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-[2-fluoro-5-(methylsulfonyl)phenyl]succinamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(4-methoxyphenyl)thiophene-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[5-(methylsulfinyl)-2,3-dihydro-1H-indol-1-yl]-4-oxobutanamide;
• 2-(acetylamino)-5-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thiophene-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-propyltetrahydro-2H-pyran-4-carboxamide;
• 4-chloro-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-2-carboxamide;
• 2-(2-chlorophenyl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,3-thiazole-4-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(3-methylphenyl)-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1,2,5-thiadiazole-3-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(phenoxymethyl)-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(4-methylphenyl)-1,3-thiazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-pyridin-3-ylbenzamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-2-phenyl-1,3-oxazole-5-carboxamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-ethyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide;
• 4-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-pyrrole-2-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,6-dimethylphenoxy)propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-phenyl-1,2,3-thiadiazole-5-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-3-carboxamide;
• 5-(acetylamino)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxybenzamide;
• 4-(acetylamino)-N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}butanamide trifluoroacetate;
• N-{(1S,2R)-1-benzyl-3-[1-ethyl-2-(4-methylpentanoyl)hydrazino]-2-hydroxypropyl}-2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(1-methyl-1H-imidazol-2-yl)benzamide;
• N1-[(1S,2R)-3-{[(1R)-3-cyclohexyl-1-phenylpropyl]amino}-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3,N3-dipropyl-5-pyridin-3-ylisophthalamide;
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-fluoro-1-naphthamide;
• N-cyclohexyl-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-methyl-1H-imidazole-2-carboxamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3-[oxo(phenyl)methyl]-beta-alaninamide
• N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[imino(phenyl)methyl]glycinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-(2-propylpentanimidoyl)-beta-alaninamide
• 6-(4-benzylpiperazin-1-yl)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}nicotinamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(3-methoxyphenyl)sulfonyl]propanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N1-(5-phenyl-1,3,4-thiadiazol-2-yl)succinamide
• N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}succinamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzamide
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[2,3-b]quinoline-2-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-5-oxo-2-phenylprolinamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine-4-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[(7-hydroxy-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio]acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxo-2,3-dihydro-1,2-benzisothiazole-6-carboxamide 1,1-dioxide
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}thieno[3,2-c]pyridine-2-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxamide
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-[oxo(phenoxy)methyl]prolinamide
• 6-chloro-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxamide
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-[4-(2,5-dioxopyrrolidin-1-yl)phenoxy]acetamide
• N2-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl) amino]-2-hydroxypropyl}-N1-phenylpyrrolidine-1,2-dicarboxamide
• 2-(1,3-benzothiazol-2-ylmethoxy)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}indolizine-2-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-phenylbutanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(3-hydroxyphenyl)-4-oxobutanamide
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-4-(3-methoxyphenyl)-4-oxobutanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3′,4′-dihydro-1′H-spiro[1,3-dioxolane-2,2′-naphthalene]-8′-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-31,4‘-dihydro-l’ H-spiro[1,3-dioxolane-2,2′-naphthalene]-7′-carboxamide
• N1-{[(S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N2-[mercapto(methylthio)methyl]-D-alaninamide
• N2-[(4-chlorophenyl) (oxo)methyl]-N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide
• N2-[(4-tert-butylphenyl) (oxo)methyl]-N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[oxo(pyridin-3-yl)methyl]glycinamide
• 2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio]-N-[4-(1,3-oxazol-5-yl)phenyl]acetamide
• N2-[(4-chlorophenyl) (oxo)methyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-D-alaninamide
• N2-[(3,4-dichlorophenyl) (oxo)methyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}glycinamide
• N-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(5a,9a-dihydrodibenzo[b,d]furan-2-yl)-4-oxobutanamide
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[oxo [4-(trifluoromethyl)phenyl]methyl]glycinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N2-[(2,6-difluorophenyl)(oxo)methyl]glycinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[oxo(4-methoxyphenyl)methyl]glycinamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(2-oxo-1,3-oxazolidin-3-yl)benzamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5-(phenylethynyl)nicotinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N3-[oxo(1H-1,2,4-triazol-5-yl)methyl]-o-alaninamide
• 2-{[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]thio}-N-(pyridin-4-ylmethyl)acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-[(methoxymethyl)thio]benzamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-oxobutanamide
• 4-(4-benzyl-1,4-diazepan-1-yl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxobutanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,5-dimethyl-1-(pyridin-4-ylmethyl)-1H-pyrrole-3-carboxamide
• N-[(dimethylamino)sulfonyl]glycyl-N1-(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]glycinamide
• N-((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-hydroxy-1-[(1R,2R)-2-hydroxycyclohexyl]prolinamide
• (2S,3S)-N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-1-methyl-5-oxo-2-pyridin-3-ylpyrrolidine-3-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2,5-dioxopyrrolidin-1-yl)benzamide
• N-(2-cyano-4,5,6,7-tetrahydro-1-benzothien-3-yl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]succinamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-2-(2,5-dioxoimidazolidin-4-yl)acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-1-(2-furylmethyl)-5-oxopyrrolidine-3-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-4-oxo-4-(5-oxo-1,4-diazepan-1-yl)butanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-5-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2,1,3-benzoxadiazole-5-carboxamide 1-oxide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(2-pyridin-3-ylpiperidin-1-yl)propanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4-oxo-4-(2-propyl-1H-imidazol-1-yl)butanamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-4a,9a-dihydro-9H-carbazole-9-carboxamide
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[1-methyl-5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(2-oxo-2-pyrrolidin-1-ylethoxy)phenyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-{[3-(hydroxymethyl)piperidin-1-yl]carbonyl}phenyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[3-(methylthio)-1-oxopropyl]-N2-pentylglycinamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-[3-(methylsulfonyl)-1-oxopropyl]-N2-pentylglycinamide
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(phenylsulfonyl)propanamide
• N′-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(7-oxabicyclo[2.2.1]hept-2-ylmethyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(3R)-2-oxo-1-propylazepan-3-yl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide
• N′-[(1S,2R)-3-[(1-acetylpiperidin-4-yl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide
• N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)-2-oxoethyl]-N,5-dimethylisophthalamide
• N′-[(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N-[2-(dimethylamino)ethyl]-N-ethyl-5-methylisophthalamide
• N-benzyl-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethylisophthalamide
• N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-t[2-(2-hydroxyethyl)piperidin-1-yl]carbonyl}-5-methylbenzamide
• N′-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethyl-N-(2-phenylethyl)isophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(3-formyl-2-furyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-2-thienyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N,5-dimethyl-N-(2-pyridin-2-ylethyl)isophthalamide
• N1-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({[1-(methylsulfonyl)piperidin-4-yl]methyl}amino)propyl]-5-methyl-N,N-dipropylisophthalamide
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-diethylpiperidine-1,3-dicarboxamide
• N′-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N3,N3-dipropylpiperidine-1,3-dicarboxamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-3-{[3-(5-formyl-4-methyl-2-thienyl)benzyl]amino}-2-hydroxypropyl)-5-methyl-N,N-dipropylisophthalamide
• N′-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[3-(1-phenylvinyl)benzyl]amino}propyl)-5-methyl-N,N-dipropylisophthalamide
• N′-[(1S,2R)-3-[(3-bicyclo[2.2.1]hept-2-ylbenzyl)amino]-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N,N-dipropylisophthalamide
• ethyl 3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]propanoate
• ethyl 4-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]aminoYmethyl)phenyl]butanoate
• methyl (2R)-3-[3-({[(2R,3S)-4-(3,5-difluorophenyl)-3-([3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)phenyl]-2-methylpropanoate
• ethyl 3′-({[(2R,3S)-4-(3,5-difluorophenyl)-3-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-2-hydroxybutyl]amino}methyl)biphenyl-2-carboxylate
• 2-{1-[2-({(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}amino)-2-oxoethyl]cyclopentyl}-N,N-dipropylacetamide
• N2-(benzyloxy) carbonyl]-N1-{(1S, 2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N2-[(benzyloxy)carbonyl]-N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-methylbutyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-[(benzyloxy)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-(cyclopropylamino)-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N2-[(benzyloxy)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(cyclopropylmethyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-([(3R)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl}-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-((1S,2R)-1-(3,5diflurobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(3S)-1,1-dioxidotetrahydrothien-3-yloxy]carbonyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-[(3S)-tetrahydrothiophen-3-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-([tetrahydropyran-4-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-diflourobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-{[1-(methylsulfonyl)piperidin-4-yloxy]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N2-{[1-acetylpiperidin-4-yloxy]carbonyl]-N1-{((S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-{[[(3R)-5-oxopyrrolidin-3-yl]methyl]carbonyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl]-N2-[(benzyloxy)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-(benzyloxy) carbonyl]-N1-((1S, 2R) -1-(3,5-difluorobenzyl)-2-hydroxy-3-{[2-(3-methoxyphenyl)ethyl]amino}propyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]-N2-{[(3S)-tetrahydrofuran-3-yloxy]carbonyl}-D-leucinamide trifluoracetate;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(benzyloxy)carbonyl]-L-leucinamide;
• N2-[(benzyloxy) carbonyl]-Nl-((1S) -1-{(1R) -2-[ethyl(isobutylsulfonyl)amino]-1-hydroxyethyl}-3-methylbutyl)-3-[(1-propylbutyl)sulfonyl]-D.L-alaninamide;
• N2-[(benzyloxy)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5,N5-dipropyl-L-glutamamide trifluoroacetate;
• N2-[(benzyloxy) carbonyl]-N1-{(1S,2R) -1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N5,N5-dipropyl-D-glutamamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-[(1H-pyrazol-4-yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-[(6-chloropyridin-3-yl)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-[(pyridin-2-yl)carbonyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(2-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-(3-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-(4-methylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-(3-chlorobenzoyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(4-methoxybenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(4-triflluoromethylbenzoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-(cyclohexylcarbonyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2(benzoyl)-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(phenylacetyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-N2-(3-phenylpropanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-(cyclopropylacetyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(methylsulfonyl)acetyl]-3-L(1-propylbutyl)sulfonyl]-D,L-alaninamide trifluoroacetate;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N2-[(methylthio)acetyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N2-(4-hydroxy-4-oxobutanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[4-(methylamino)-4-oxobutanoyl]-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-N2-(4-methoxy-4-oxobutanoyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N-(methylsulfonyl)glycyl-N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-acetyl-N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl)-3-(phenylsulfonyl)-D,L-alaninamide;
• (2S)-2-(4-methoxy-4-oxobutanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-{[(benzyloxy)carbonyl]amino}-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-(3-ethoxy-3-oxopropanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• N1-{[(S,2R)-1-benzyl-3-[(3-methoxybenzyl)amino]-2-hydroxypropyl}-N2-(4-methoxy-4-oxobutanoyl)-N5,N5-dipropyl-D-glutamamide;
• (2R)-2-(4-methoxy-4-oxobutanoyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-(5-methoxy-5-oxopentanoyl)amino-N-((S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• N2-[(5-chlorothien-2-yl)sulfonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl)-N2-(phenylsulfonyl)-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• N2-[(benzylamino)carbonyl]-N1-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-[(1-propylbutyl)sulfonyl]-D,L-alaninamide;
• 4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)-3-[(isopentylsulfonyl)methyl]-4-oxobutanoic acid;
• methyl 4-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)-3-[(isopentylsulfonyl)methyl]-4-oxobutanoate;
• N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]succinamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]-N4-methylsuccinamide;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)methyl]-N4,N4-dimethylsuccinamide;
• N-((1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-{[(1-propylbutyl)sulfonyl]methyl}propanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(ethylsulfonyl)-2-{[(isobutylsulfonyl)amino]methyl}propanamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-3-(ethylthio)-2-{[(isobutylsulfonyl)amino]methyl}propanamide;
• (2S)-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-[(isopentylsulfonyl)amino]-4-(methylsulfonyl)butanamide;
• N1-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-(isopentylsulfonyl)-L-methioninamide;
• S-[3-({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl]amino)-2-[(isopentylsulfonyl)methyl]-3-oxopropyl}ethanethioate;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-3-[(1-propylbutyl)sulfonyl]propanamide;
• N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(isopentylsulfonyl)butanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(isopentylsulfonyl)-2-phenoxybutanamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(isopentylsulfonyl)-2-(3-methoxyphenoxy)butanamide;
• 3-[1-[({(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-3-(isopentylsulfonyl)propoxy]benzoic acid trifluoroacetate;
• methyl 3-[1-[([(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}amino)carbonyl]-3-(isopentylsulfonyl)propoxy]benzoate;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(phenylsulfonyl)butanamide;
• N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-hydroxy-4-(phenylthio)butanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methoxy-4-(phenylsulfonyl)butanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-methoxy-4-(phenylthio)butanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-4-(phenylsulfonyl)-2-propoxybutanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-2-(benzyloxy)-4-(phenylsulfonyl)butanamide;
• N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(benzyloxy)carbonyl]-D,L-methioninamide;
• (2S)-2-amino-N-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2S)-2-(2-ethoxy-2-oxoethanyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-(2-ethoxy-2-oxoethanyl)amino-N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide;
• (2R)-2-(4-ethoxy-4-oxobutanyl)amino-N-[(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-oxo-5-piperidin-1-ylpentanamide ditrifluoroacetate;
• N1-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(benzyloxy)carbonyl]-L-aspartamide;
• N1-((1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N2-[(tertbutyloxy)carbonyl]-L-aspartamide;
• or a pharmacuetically acceptable salt thereof.