Method for producing optical-active cis-piperidine derivatives
OwnerToshihiro Fujino, Seiji Morii +1inventors
InventorsToshihiro Fujino, Seiji Morii, Haruyo Sato
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Abstract
An optical-active cis-piperidine derivative of high chemical purity and high optical purity is efficiently produced through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative with an optical-active tartaric acid derivative or an optical-active amino acid derivative. For the optical-active tartaric acid derivative, preferred are optical-active di(paratoluoyl)tartaric acid and optical-active di(4-methoxybenzoyl)tartaric acid; and for the optical-active amino acid derivative, preferred is optical-active N-benzenesulfonylphenylalanine.
Claims10
A method for producing optical-active cis-piperidine derivatives through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative of the following general formulae (1) and (2) with an optical-active tartaric acid derivative or an optical-active amino acid derivative:
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- wherein R1 and R2 each represent a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms;
- R3 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, or a halogen atom;
- n indicates an integer of from 0 to 3.
Dependencies are inferred from the claim text.