Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient

A tetrahydroquinoline derivative compound represented by formula (I)

• 177
• wherein
• A represents (1)-COOR1, or 1H-tetrazol-5-yl,
• R1 represents (1) hydrogen atom, or (2) C1-10 alkyl,
• R2 and R3 each independently represents (1) hydrogen atom, or (2) C1-10 alkyl or taken together with the carbon atom to which they are attached, represents C3-7 cycloalkylene,
• X represents (1) bond, or (2)C1-3 alkylene,
• Y represents (1)—O—, or (2)—S—,
• Z represents C1-4 alkylene,
• Cyc1 and Cyc2 each independently represents
• (1) partially or fully optionally saturated C3-15 mono-, bi-, or tri-carbocyclic aryl, or
• (2) partially or fully optionally saturated 3-15 membered mono-, bi- or tri-heterocyclic aryl containing 1-4 hetero atom(s) selected from oxygen, nitrogen or sulfur atom,
• R4 and R5 each independently represents
• (1) C1-10 alkyl, (2) C2-10 alkenyl, (3) C2-10 alkynyl, (4) C1-10 alkoxy, (5) C1-10 alkylthio, (6) halogen atom, (7) trihalomethyl, (8) trihalomethoxy, (9) trihalomethylthio, (10) cyano, (11) nitrile, or (12)—NR6R7,
• R6 and R7 each independently represents C1-10 alkyl,
• m and n each independently represents 0 or integer of 1-3, or
• a nontoxic salt thereof.