Anti-arthropod vector vaccines method of selecting and uses thereof
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M.C. Ribeiro
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Abstract
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.
Claims34
An isolated nucleic acid, encoding a salivary polypeptide of Phlebotomus papatasi.
An isolated salivary polypeptide of Phlebotomus papatasi.
A nucleic acid that hybridizes under stringent conditions to the nucleic acids of SEQ ID NOS:19-27.
A vector comprising at least one nucleic acid or fragment thereof, selected from the group consisting of SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:26 and SEQ ID NO:27.
A composition comprising at least one polypeptide or fragment thereof, selected from the group having the amino acid sequence of SEQ ID NO:10, SEQ ID NO:1 1, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17 and SEQ ID NO:18 and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.