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US 2004/0171819 A1Published application
Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
AssigneeAventis Pharma S.A.
InventorChristian Viskov
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Abstract
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
Claims53
A mixture of sulfated oligosaccharides having the general structure of the constituent polysaccharides of heparin and having the following characteristics:
- a mean molecular weight of 1500 to 3000 daltons, an anti-Xa activity of 120 to 200 IU/mg, an anti-IIa activity of less than 10 IU/mg and an anti-Xa activity/anti-IIa activity ratio of greater than 30,
- wherein the constituent oligosaccharides of said mixtures:
- contain 2 to 26 saccharide units,
- have a 4,5-unsaturated uronic acid 2-O-sulfate unit at one of their ends,
- contain the hexasaccharide ΔIIa-IIs-Is of formula:
- 6
- and are in the form of an alkali or alkaline-earth metal salt:
4 more elements
Dependencies are inferred from the claim text.