Humanized antibodies that recognize beta amyloid peptide

A humanized antibody, or fragment thereof, comprising a humanized light chain comprising three light chain complementarily determining regions (CDRs) from the mouse monoclonal antibody 10D5 and a light chain variable region framework sequence from a human immunoglobulin light chain;

• and a humanized heavy chain comprising three heavy chain CDRs from the mouse monoclonal antibody 10D5 and a heavy chain variable region framework sequence from a human immunoglobulin heavy chain;
• wherein the light chain CDRs have the following amino acid sequences:
• light chain CDR1:
• 26 Arg Ser Ser Gln Asn Ile Ile His Ser Asn Gly (residues 24-39 of SEQ ID NO:14) Asn Thr Tyr Leu Glu
• light chain CDR2:
• 27 Lys Val Ser Asn Arg Phe Ser (residues 55-61 of SEQ ID NO:14)
• light chain CDR3:
• 28 Phe Gln Gly Ser His Val Pro Leu Thr (residues 94-102 of SEQ ID NO:14)
• and the heavy chain CDRs have the following amino acid sequences:
• heavy chain CDR1:
• 29 Thr Ser Gly Met Gly Val Ser (residues 31-37 of SEQ ID NO:16)
• heavy chain CDR2:
• 30 His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser (residues 52-67 of SEQ ID NO:
• 16) and,
• heavy chain CDR3:
• 31 Arg Pro Ile Thr Pro Val Leu Val Asp Ala Met Asp Tyr (residues 100-112 of SEQ ID NO:
• 16).