Artificial protein having potentiated immunogenicity of epitope

Abstract

The present invention provides a method for efficiently constructing a specific antibody having a neutralizing activity for AIDS or the like, by imparting an ability to induce a strong immunoresponse to peptidic epitope such as the gp120 loop 3 of HIV or the like, from which sufficient immunoresponsive induction activity cannot be obtained by the conventional methods. An artificial protein having epitope with potentiated immunogenicity, comprised of an amino acid sequence containing whole or part of an amino acid sequence of a peptidic epitope and having a property imparted thereto of assisting the formation of the high-order structure of protein, and an amino acid sequence having a property imparted thereto of assisting the antigen presentation treatment caused by immunocompetent cell, is prepared. Subsequently, an antibody against the above-mentioned peptidic epitope is efficiently constructed by a conventional method with the use of said artificial protein.

Dependencies are inferred from the claim text.