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US 2004/0171795 A1Published application
Novel peptides
OwnerShinichi Kuriyama, Yasushi Taguchiinventors
Life of this patent
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Abstract
Peptides which are capable of binding to a gene and transferring this gene into cells, have an affinity with phosphatidylserine, have a high safety and an excellent selectivity, can be easily formulated into a complex with the gene and can serve as a vector having a high gene transfer efficiency into cells.
Claims13
A peptide including a sequence comprising 18 amino acids, wherein
- said sequence of 18 amino acids is constituted from alternately arranged two hydrophobic sides and two hydrophilic sides in α-helix structural model depicted by Edmundson wheel plots,
- one of said hydrophobic sides comprises 5 to 7 amino acids and 80 mole % or more of this side comprises hydrophobic amino acids,
- one of said hydrophilic sides comprises 5 to 6 amino acids, and 80 mole % or more of this side comprises hydrophilic amino acids, and 50 mole % or more of this side comprises an amino acid selected from arginine and lysine,
- the other side of said hydrophobic sides comprises 2 to 4 hydrophobic amino acids, and
- the other side of said hydrophilic sides comprises 3 to 5 amino acids, and 80 mole % or more of this side comprises hydrophilic amino acids.
2 more elements
A peptide having the amino acid sequence of any one of SEQ ID NO:1 to SEQ ID NO:24.
A peptide of SEQ ID NO:16 or SEQ ID NO:19.
Dependencies are inferred from the claim text.