Back to results
US 2004/0171793 A1Published application
Cyclic peptides as potent and selective melanocortin-4 receptors agonists
AssigneeMerck & Co., Inc.
InventorMaria A. Bednarek
Life of this patent
Estimating the term…
Abstract
Cyclic peptides of formula I are potent and selective agonists of melanocortin-4 receptors, and as such are useful research tool for the determination of the physiological roles of the MC-4 receptor, as well as for the diagnoses, treatment or prevention of disorders or diseases mediated through the MC-4 receptor.
Claims12
A compound having the formula I:
- 3
- wherein,
- His is L-histidyl;
- D-Phe(X) is D-phenylalanyl optionally para-substituted with a group selected from F, Cl, Br, Me, OMe;
- Arg is L-arginyl;
- W is L-tryptophanyl or 2-naphthyl-L-alanyl;
- one of Y and Z is —C(O)— and the other is —NH—;
- m is 1 to 4;
- n is 1 to 4, provided that n+m is 4 to 6;
- or
- a salt thereof.
8 more elements
Dependencies are inferred from the claim text.